Ask about this productRelated genes to: NSUN6 antibody
- Gene:
- NSUN6 NIH gene
- Name:
- NOP2/Sun RNA methyltransferase 6
- Previous symbol:
- NOPD1, ARL5B-AS1
- Synonyms:
- FLJ23743
- Chromosome:
- 10p12.31
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-21
- Date modifiied:
- 2019-02-26
Related products to: NSUN6 antibody
Related articles to: NSUN6 antibody
- Perioperative neurocognitive disorders (PND) are common in elderly patients, with emerging evidence linking their pathogenesis to abnormal cell death. PANoptosis is a newly identified inflammatory form of programmed cell death, but its role in PND remains unknown. Here, we employed animal behavioral tests, single-cell sequencing (scRNA-seq), methylated RNA immunoprecipitation-sequencing (meRIP-seq), RNA sequencing (RNA-seq), immunofluorescence, and TUNEL staining to investigate the role and underlying mechanisms of PANoptosis in PND. Y-maze and open-field experiments confirmed cognitive and locomotor deficits in a PND mouse model. scRNA-seq revealed altered cellular composition and neuronal heterogeneity in PND brain tissues, with elevated PANoptosis-related gene expression and scores in PND neurons. In vivo and in vitro assays confirmed increased expression of PANoptosis markers (ASC, AIM2, Pyrin) and neuronal apoptosis in PND. Based on the differentially expression gene (DEG) analysis conducted using scRNA-seq, we identified NSUN6 as a key gene that was significantly downregulated in neurons of the PND group, and overexpression of NSUN6 suppressed isoflurane-induced neuronal PANoptosis. RNA-seq and meRIP-seq further revealed that NSUN6 promoted m5C modifications enriched in CDSs and 3' UTRs, with pathway analysis implicating PANoptosis-associated signaling. OAS2 was identified as a direct substrate of NSUN6-mediated m5C modification, with NSUN6 overexpression enhancing both its m5C enrichment and expression. Collectively, our findings suggest that NSUN6 may be involved in OAS2-associated m5C modification and neuronal PANoptosis, supporting a potential role for the NSUN6/OAS2 axis in the pathogenesis of PND. - Source: PubMed
Publication date: 2026/05/07
Gong XinhaoLiu WenLuo HanqingA RunnaHu YulongHu YingchuanFeng XiaojinChen Shoulin - - Source: PubMed
Publication date: 2026/04/09
Chen CanPan Shi-YiXu JiaCao XinyuanZhang Wei-MingXu Hua-Guo - The epigenetic modification of transfer RNA (tRNA) and tRNA-derived small RNAs (tsRNAs) is associated with the initiation and development of cancer. However, the biological role of mC-modified tsRNAs, especially in bladder cancer (BC), and their regulatory mechanisms remain unclear. Here, we identify a novel mC-modified tsRNA, mC-tRF3b-Cys-23 (mtRC), whose expression is significantly downregulated in both tumor tissues and urine samples of BC patients and is strongly negatively correlated with the malignant progression of bladder cancer. In vitro and in vivo functional experiments reveal that mtRC, but not its unmodified counterpart (tRC), exhibits a tumor-suppressive role. Furthermore, NOP2/Sun RNA methyltransferase 6 (NSUN6) regulates mtRC abundance and suppresses cell proliferation. Mechanistically, mtRC directly binds the oncosuppressor protein RNA-binding motif 4 (RBM4) and improves its stability by preventing RBM4 ubiquitination, thereby upregulating RBM4 protein levels. RBM4 reduces the levels of glycolytic genes and decreases glycolysis, thereby inhibiting histone H3 lysine 18 lactylation (H3K18la). This reduction in H3K18 lactylation attenuates the transcriptional activation of the downstream oncogenes IL1RAP and VASH2, thereby ultimately suppressing tumor malignancy in BC. Together, our results not only underscore the critical role of mtRC in BC but also unravel a novel and coherent regulatory signaling axis-mtRC/RBM4/H3K18la/IL1RAP&VASH2-that orchestrates BC malignancy, suggesting mtRC may serve as a candidate therapeutic target for BC treatment. - Source: PubMed
Publication date: 2026/02/27
Ying XiaolingHuang YapengHuang JianCai QinyuZhang DanniChen CongNie YuxiYang BaotongLi ChuanHu WenyuXiong ChangZhang ChengchengJi DingLiang YaominYang MeiWu WenqiJi Weidong - Osteosarcoma (OS) is a highly aggressive malignant bone tumor with poor prognosis. Both Plakophilin 2 (PKP2) and NOP2/Sun RNA methyltransferase 6 (NSUN6) were reported to be upregulated in OS, and NSUN6 is one of the important RNA methyltransferases catalyzing 5-methylcytosine (m5C) formation and participates in many critical bioprocesses in various tumors. However, the roles and underlying molecular mechanisms of NSUN6-mediated m5C modification in OS remain unclear. - Source: PubMed
Publication date: 2026/02/11
Zhao ChunyanTang YunHe YongpengZhang FagenLi WenqianChen XiaochunYu ZhengyangFu Kaiwen - RNA 5-methylcytosine (mC) has emerged as a critical epigenetic regulator in cancer biology, yet its role in the tumour immune microenvironment (TME) remains incompletely understood. - Source: PubMed
Publication date: 2026/01/22
Zeng LingxingLiu ShuangPeng XinyiXue ChunlingWang DaoyuanBai RuihongLiu ShaoqiuChen ZimingZhao HongzheXu ZilanZhao SihanZhou YifanWu XiaoyuWu ShaojiaLi MeiLiu JiZhang JialiangZhou QiHuang XudongSu Jiachun