Ask about this productRelated genes to: MGC27016 antibody
- Gene:
- RBM46 NIH gene
- Name:
- RNA binding motif protein 46
- Previous symbol:
- -
- Synonyms:
- MGC27016, CT68
- Chromosome:
- 4q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 2007-10-24
- Date modifiied:
- 2019-03-19
Related products to: MGC27016 antibody
Related articles to: MGC27016 antibody
- Bladder cancer is a prevalent malignancy, with high recurrence rates for non-muscle invasive cases and significant progression risks. Traditional diagnostic methods, such as cystoscopy and urine cytology, are limited by their invasiveness and low sensitivity for detecting low-grade tumors, respectively. Advances in non-invasive diagnostics focus on biomarkers such as cfDNA and DNA methylation, offering promising tools for early detection. - Source: PubMed
Publication date: 2026/01/06
Mahdipour ShadiModarressi Mohammad HosseinNoruzinia Mehrdad - Histone lysine-specific demethylase 4A (KDM4A) plays a critical role in the embryonic development of mammals such as mouse and goat, however its function in zebrafish () embryogenesis remains poorly understood, due to the existence of two paralogs ( and ) in zebrafish. The current study revealed that embryos exhibited dramatically increased mortality during gastrulation. RT-qPCR showed that RNA-binding motif protein 46 () was downregulated after knockout. CUT&Tag-qPCR revealed that knockout significantly decreased H3K4me3, while increasing H3K9me3 and H3K36me3 at promoter. embryos displayed elevated reactive oxygen species (ROS) and reduced adenosine triphosphate (ATP). And mRNA injection alleviated ROS accumulation and increased ATP level, thereby rescuing the lethal phenotype in embryos. Our findings demonstrate that knockout disturbs zebrafish embryogenesis by suppressing mRNA expression. - Source: PubMed
Publication date: 2026/03/09
Jiang HuiCai XinqingDeng RuiWang JiaminSong HongkuanChai WeiranHan BingsheZhang Junfang - is a commercially valuable freshwater fish in the Pearl River Basin, renowned as the "King of Freshwater Fish." Due to habitat degradation and overfishing, its wild population has declined sharply, leading to its listing as a National Key Protected Wild Animal of Class II in China. Artificial breeding is therefore crucial for conservation, yet progress is hindered by the lack of clear sexual dimorphism and poor understanding of its sex differentiation mechanism. In this study, we performed high-throughput RNA sequencing (RNA-seq) to compare gonadal transcriptomes of male and female . A total of 3245 differentially expressed genes (DEGs) were identified, including 3122 male-biased and 123 female-biased DEGs, which clustered into three distinct expression patterns. Enrichment analysis revealed that genes associated with the TGF-β (Transforming Growth Factor-beta) and GnRH (Gonadotropin-Releasing Hormone) signaling pathways were significantly enriched in the female gonads, suggesting their potential roles in gonadal differentiation. From the DEG set, we further highlighted five genes with pronounced sex-biased expression: (RNA Binding Motif Protein 46) exhibited gonad-specific expression, whereas (v-myc avian myelocytomatosis viral oncogene homolog), (Angiopoietin-Like 4), (SRY-Related HMG-Box Gene 9), and (Frizzled Class Receptor 2) showed marked expression differences between male and female gonads. These findings provide insights into the molecular mechanisms underlying sex differentiation in , offer potential molecular markers for sex identification, and establish a scientific basis for germplasm conservation and the optimization of breeding techniques. - Source: PubMed
Publication date: 2025/12/09
Luo WenyinHuang ShaojunLi GuanglveHu DanChen JiemeiLi HuiqinYu HeminChen YanyunZhu JiajieHu Qiaomu - This study investigated the toxic effects and mechanisms of trichlorfon (TCF) on the hepatopancreas of Chinese mitten crabs (Eriocheir sinensis). The acute toxicity test results showed that the 96 h-LC of TCF on E. sinensis was 4.853 mg/L. We conducted an 8-day short-term exposure experiment with TCF concentrations of 0, 0.061, 0.121, and 0.243 mg/L. The results showed that TCF exposure induces oxidative stress and causes tissue damage and lesions to the hepatopancreas, including hepatic tubules exhibiting disruption, swelling, necrosis, and an ill-defined structure. Transcriptomics revealed differentially expressed genes (DEGs) at the different concentrations, KEGG, and GO enrichment analysis showed that the DEGs were mainly involved in the bile secretion pathway and iron ion binding terms. GSEA was used for single-function enrichment analysis of cell growth and death. We found that DEGs at TCF concentrations of 0.121 and 0.243 mg/L were significantly enriched in the Ferroptosis pathway. Moreover, the synaptic vesicle cycle, GABAergic synapse, and serotonergic synapse were significantly enriched in DEGs at 0.243 mg/L, which indicated that TCF may pose a potential threat to the nervous system. The qPCR detection of Ferroptosis-related genes demonstrated that TCF induces hepatopancreatic Ferroptosis in E. sinensis. We hypothesized that lysosomal autophagy, mainly induced through FTH1 and NCOA4 interactions, released ferric ions, thereby indirectly contributing to Ferroptosis. In addition, WGCNA identified two key modules associated with the phenotype, and further identified the core hub genes were MEX3, RBM46, SLC7A5, and TYR. The results of this study can provide insights into the toxic effects of TCF on aquatic crustaceans. - Source: PubMed
Publication date: 2025/08/11
Zhu TianZhang YanSong MeiqiChen YunyiZanuri Norlaila MohdPeng GangGao TianhengJiang Qichen - - Source: PubMed