Ask about this productRelated genes to: ZCRB1 antibody
- Gene:
- ZCRB1 NIH gene
- Name:
- zinc finger CCHC-type and RNA binding motif containing 1
- Previous symbol:
- -
- Synonyms:
- MADP-1, MADP1, RBM36, ZCCHC19, SNRNP31
- Chromosome:
- 12q12
- Locus Type:
- gene with protein product
- Date approved:
- 2006-01-25
- Date modifiied:
- 2016-11-09
Related products to: ZCRB1 antibody
Related articles to: ZCRB1 antibody
- The high incidence and recurrence of hepatoma necessitate better prognostic tools. Given the established cytotoxic role of CD4+ T cells, this study aimed to identify CD4+ T cell-related genes (TRGs) and their mechanisms in hepatoma. - Source: PubMed
Publication date: 2026/04/27
Zhang ZheweiGuo LiwenLuo JunZheng JiapingZeng Hui - - Source: PubMed
Publication date: 2026/02/28
Xu QiongyingHan JiehuaZhu Jiali - RNA splicing dysregulation plays an important role in hepatocellular carcinoma (HCC). However, the critical functions of zinc finger CCHC type and RNA binding motif 1 (ZCRB1), one of the key components of the minor spliceosome, in HCC remains unclear. - Source: PubMed
Publication date: 2025/11/19
Zhang FanYao ZhipengGao HengjunShi RuoyuXu YanZhang ChengfeiZhao PanpanLi TaoCheng ZhangjunZha YongXia Hongping - Despite the fact that 0.5% of human introns are processed by the U11/U12 minor spliceosome, the latter influences gene expression across multiple cellular processes. The ZCRB1 protein is a recently described core component of the U12 mono-snRNP minor spliceosome, but its functional significance to minor splicing, gene regulation, and biological signaling cascades is poorly understood. Using CRISPR-Cas9 and siRNA targeted knockout and knockdown strategies, we show that human cell lines with a partial reduction in ZCRB1 expression exhibit significant dysregulation of the splicing and expression of U12-type genes, primarily due to dysregulation of U12 mono-snRNA. RNA-Seq and targeted analyses of minor intron-containing genes indicate a downregulation in the expression of genes involved in ciliogenesis, and consequentially an upregulation in WNT signaling. Additionally, CRISPR-Cas12a knockdown in zebrafish embryos led to gross developmental and body axis abnormalities, disrupted ciliogenesis, and upregulated WNT signaling, complementing our human cell studies. This work highlights a conserved and essential biological role of the minor spliceosome in general, and the ZCRB1 protein specifically in cellular and developmental processes across species, shedding light on the multifaceted relationship between splicing regulation, ciliogenesis, and WNT signaling. - Source: PubMed
Publication date: 2024/08/10
Powell-Rodgers GerallePirzada Mujeeb Ur RehmanRichee JahmieraJungers Courtney FColijn SarahStratman Amber NDjuranovic Sergej - Head and neck squamous cell carcinoma (HNSCC) is the most frequent subtype of head and neck cancer, generally with a poor prognosis and limited therapeutic options due to its highly heterogeneous malignancy. In this study, we screened functional splicing regulatory RNA binding proteins (RBPs) that were closely related with the prognosis of HNSCC patients and showed significant expression differences between HNSCC tumors and normal tissues. Based on this finding, we chose six candidate genes (HNRNPC, ZCRB1, RBM12B, SF3A2, SF3B3, and SRSF11) to generate a prognostic prediction model and validated the accuracy of the prognostic model for predicting patient survival outcomes. We found that the risk score predicted by our model can serve as an independent prognostic predictor. Notably, HNSCC tumors showing higher expression of SF3B3, HNRNPC, or ZCRB1 possessed higher risk scores in the discovered prediction model. The investigation of the underlying mechanism validated that knockdown of SF3B3, HNRNPC, and ZCRB1 separately induced a substantial impairment of HNSCC cell survival. Conversely, overexpression of each of the three genes promoted tumor cellular proliferation. High throughput RNA sequencing analysis revealed that changes in the expression of SF3B3 and HNRNPC remarkably affected alternative splicing of genes related to cell cycle regulation, whereas the depletion of ZCRB1 contributed to aberrant splicing events involving in DNA damage response. In addition, the prognostic prediction model's risk score was demonstrated to be related with the immune infiltration score. Particularly, SF3B3 has a negative correlation with CD8A expression. Therefore, our findings provide promising prognosis predictors and potential therapeutic targets for better treatment efficacy of HNSCC. - Source: PubMed
Publication date: 2024/03/06
Chen ChaoqunHuang FangLi XiaojieLiu LinZhang JinruiZhao JinyaoZhang WenjingLi HuizhengXu WeiQi YangfanWang Yang