Ask about this productRelated genes to: ADARB2 antibody
- Gene:
- ADARB2 NIH gene
- Name:
- adenosine deaminase RNA specific B2 (inactive)
- Previous symbol:
- -
- Synonyms:
- RED2, hRED2, ADAR3
- Chromosome:
- 10p15.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-10-02
- Date modifiied:
- 2019-01-18
Related products to: ADARB2 antibody
Related articles to: ADARB2 antibody
- Pediatric obesity is the most prevalent nutritional disorder in children and adolescents and is associated with multiple comorbidities. Understanding epigenetic mechanisms, particularly DNA methylation, offers potential for early risk prediction, prevention, and personalized interventions. In this study, genome-wide DNA methylation profiles in blood from children with obesity and matched controls were compared using Oxford Nanopore Technologies. Two independent analytical tools were applied to identify differentially methylated regions. Clinical data included family history, weight, BMI, and age at first examination. Participants with monogenic obesity, identified via short-read whole-exome sequencing, were excluded. - Source: PubMed
Publication date: 2026/05/12
Slapnik BarbaraŠket RobertVrhovšek BlažKotnik PrimožBattelino TadejKovač Jernej - Accurate sex identification in reptiles with genotypic sex determination is essential for breeding management, veterinary care and evolutionary research, yet commonly used methods are often invasive, stressful or unreliable. This study aimed to evaluate a dosage-based quantitative PCR approach for molecular sex determination in caenophidian snakes, using naturally shed epidermal skin as a non-invasive DNA source. Genomic DNA extracted from shed skin was analysed by qPCR targeting conserved Z-linked genes (, and ), together with autosomal and reference genes, to assess sex-specific differences in gene copy number. Sixteen caenophidian snake species were examined, including taxa for which molecular sexing data are currently scarce or unavailable. The autosomal control gene showed dosage ratios close to parity between sexes, supporting DNA quality and reference gene reliability; meanwhile, Z-linked markers generally exhibited reduced dosage in females relative to males, consistent with a ZZ/ZW sex determination system. These results demonstrate that dosage-based qPCR applied to shed epidermal skin provides a promising and non-invasive framework for molecular sex determination in caenophidian snakes, without compromising animal welfare. - Source: PubMed
Publication date: 2026/04/11
Enacrachi George IulianPaştiu Anamaria IoanaPusta Dana Liana - The prevalence of Type 2 diabetes mellitus (T2DM) is rapidly increasing in India, yet molecular markers that reflect early disease susceptibility remain limited. Epigenetic modifications such as DNA methylation may reflect early metabolic vulnerability preceding overt dysglycemia. In this study, we examined genome-wide DNA methylation patterns in a pilot subset nested within a prospective Indian cohort using Nanopore sequencing and assessed their associations with previously identified metabolite predictors from the same cohort. - Source: PubMed
Publication date: 2026/04/16
Satheesh GopikaAsokan Aneesh KVijayakumar GadadharanRajavelu ArumugamRao Sudha NarayanaSivakumar Krishnankutty ChandrikaJaleel Abdul - ADAR1 (), ADAR2 (), and ADAR3 () are deaminase adenosine RNA-specific enzymes that play a significant role in RNA metabolism. ADAR1 () and ADAR2 () catalyze A-to-I editing and ADAR3 () plays a regulatory role. The role of these three genes still remains unknown in head and neck cancers (HNSCC). The aim of this study is to reveal the role of deaminase adenosine RNA-specific enzymes in pathomechanisms of HNSCC and to investigate their potential utility as diagnostic and/or prognostic biomarkers. The quantitative PCR analysis was conducted using RNA isolated from 22 pairs of matched tumor and adjacent normal tissues, 76 formalin-fixed paraffin-embedded (FFPE) tumor samples, and a panel of HNSCC cell lines (DOK, SCC-25, SCC-40, FaDu, and CAL-27). In parallel, transcriptomic and clinical data from the Cancer Genome Atlas HNSCC cohort were analyzed. Patients were stratified into high- and low-expression groups, and statistical assessments included overall survival and progression-free interval analyses, evaluation of gene expression in relation to clinicopathological parameters, correlation with other genes, and functional pathway exploration using gene set enrichment analysis. ADARB2 was significantly downregulated in HNSCC tumor tissues compared to adjacent normal mucosa ( = 0.044), with discriminatory potential to distinguish malignant from non-malignant tissues (AUC = 0.692, = 0.029). TCGA data confirmed ( < 0.0001) and ( < 0.0001) upregulation in tumors, while was markedly reduced ( = 0.04). Patients with high expression showed significantly longer overall survival (pa = 0.0121; pb = 0.0098), with a trend toward improved progression-free survival (pb = 0.0681). Subsite analysis revealed high expression correlated with poor OS in pharyngeal tumors ( < 0.05), whereas high expression was linked to improved DFS (pa = 0.0023, pb = 0.0047). GSEA indicated that low expression was enriched in oncogenic pathways, including Wnt/β-catenin ( = 0.006), MYC targets ( = 0.009), and TGF-β1 ( = 0.009). expression was significantly reduced in HNSCC tumor tissues compared to normal mucosa and demonstrated strong discriminatory power for distinguishing malignant from non-malignant samples. High expression was associated with markedly improved overall survival, whereas low expression correlated with enrichment of oncogenic pathways, including Wnt/β-catenin, Notch, and Hedgehog, consistent with a poorer clinical prognosis. These findings highlight as a promising diagnostic biomarker and independent prognostic factor in HNSCC. - Source: PubMed
Publication date: 2025/11/02
Kolenda TomaszBiałas PiotrPoter PaulinaJaniczek-Polewska MarlenaZapłata AnnaGuglas KacperMantaj PatrycjaPrzybyła AnnaKazimierczak UrszulaLeporowska EwaCybulski ZefirynTeresiak Anna - The prognosis of lung adenocarcinoma (LUAD) is poor, and clinical treatment mainly comprises a combination of traditional therapy and immunotherapy. However, the role and mechanism of tumor-infiltrating regulatory T cells (Tregs) in immunotherapy remain controversial. Therefore, we aimed to determine the role of Tregs in LUAD and to construct a relevant prognostic model for future clinical treatment. - Source: PubMed
Publication date: 2025/11/11
Zhao TianYao YanSun YanLv QingliangSun ChanggangCheng YiningGao ChundiZhuang Jing