Ask about this productRelated genes to: BRUNOL5 antibody
- Gene:
- CELF5 NIH gene
- Name:
- CUGBP Elav-like family member 5
- Previous symbol:
- BRUNOL5
- Synonyms:
- -
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-28
- Date modifiied:
- 2017-01-20
Related products to: BRUNOL5 antibody
Related articles to: BRUNOL5 antibody
- Genetically defined neurodevelopmental syndromes provide a framework for examining constraints on language development. This study compared language performance in children and adolescents with 22q11.2 deletion syndrome (22q11.2DS; n = 40) and Down syndrome (DS; n = 40), matched for age and nonverbal cognitive ability, aged 6-16 years. Standardized assessments included the Clinical Evaluation of Language Fundamentals (CELF-5) and the BLOC-C to evaluate multiple receptive and expressive language domains. Group differences, effect sizes, and associations with age were analyzed to characterize syndrome-specific profiles. Children with 22q11.2DS demonstrated relatively stronger receptive vocabulary and syntax alongside weaker morphosyntactic and pragmatic skills, with vocabulary showing moderate positive associations with age. In contrast, the DS group exhibited generally lower performance across domains, with pronounced difficulties in morphosyntax and limited age-related gains. These findings highlight differences in overall level of performance and relative strengths within a globally impaired profile across syndromes and emphasize the value of multi-dimensional assessment in capturing both age-related patterns and vulnerabilities. - Source: PubMed
Publication date: 2026/05/26
Moraleda-Sepúlveda EstherLázaro-López-Villaseñor MiguelPulido-García NoeliaBenomar-Simou Hoda - This study examined the role of auditory processing in autism spectrum disorder, focusing on its association with verbal and non-verbal vocal communication skills in children and adolescents. A total of 97 English-speaking autistic participants (ages 7.9-17.4 years, mean = 12.3) and 44 neurotypical peers (ages 8.4-16.8, mean= 12.3) completed assessments of auditory processing and communication skills. We analyzed the relationships between scores on the SCAN-3 Tests for Auditory Processing Disorders time-compressed sentences, auditory figure-ground (+ 8dB), gap detection, and competing words-free recall subtests, the Clinical Evaluation of Language Fundamentals-Fifth Edition (CELF-5) expressive and receptive language indices, the Goldman-Fristoe Test of Articulation-3rd Edition (GFTA-3) Sounds-In-Words subtest, and the Diagnostic Analysis of Nonverbal Accuracy-2nd Edition (DANVA-2) paralanguage subtests. Measures of auditory processing were associated with both verbal and non-verbal communication skills in the autistic participants. Specifically, we found that SCAN-3 time-compressed sentence and gap detection scores were associated with expressive and receptive language skills, receptive vocabulary scores, and ability to recognize vocal emotional cues. Gap detection abilities additionally correlated positively with expressive and receptive language skills, while auditory figure-ground task performance was related to articulation. In conclusion, this study suggests specific aspects of auditory processing may be important for development of specific aspects of auditory communication skills in children on the spectrum. Specifically, spectral aspects of auditory processing abilities were associated with articulation accuracy whereas temporal components of auditory processing may impact broader verbal and nonverbal communication skills. Further research is needed to better understand the underlying mechanisms of these associations and potential directions of causality to inform development of interventions that target auditory processing and auditory communication skills in ASD. - Source: PubMed
Publication date: 2026/04/23
Gallo AlecSabes Jennifer HendersonDemopoulos Carly - This study evaluates the impact of a comprehensive remedial program within the "Literary Reading" curriculum on the spoken language development of deaf and hard-of-hearing children in grades 2-4, aligned with Kazakhstan's communicative paradigm of primary education. A total of 150 students aged 7-10 participated. The six-month intervention included interdisciplinary integration, auditory training, and spoken language reading strategies. The Clinical Evaluation of Language Fundamentals (adapted into Russian) was used for assessment. Linear mixed-effects models revealed significant Group × Time interactions across all CELF-5 indices, indicating substantially greater pre-to-post language gains in the experimental group compared to the control group. Significant effects were observed for the Core Language Score (β = -6.30, SE = 0.43, z = -14.72, < 0.001), Receptive Language Index (β = -5.17, SE = 0.36, z = -14.53, < 0.001), Expressive Language Index (β = -5.42, SE = 0.41, z = -13.22, < 0.001), Language Content Index (β = -5.03, SE = 0.40, z = -12.58, < 0.001), and Language Memory Index (β = -4.79, SE = 0.42, z = -11.41, < 0.001). While the control group showed only minimal developmental changes, the experimental group demonstrated pronounced improvements across all language domains. The findings support the effectiveness of the program in improving spoken language skills among children who are deaf or hard of hearing. Its success in Kazakhstan suggests potential for adaptation in other Russian-speaking educational contexts focused on corrective learning for children with special needs. - Source: PubMed
Publication date: 2026/03/23
Saurykova BaglanSaurykova KuralayYeleussizkyzy MeruyertZhiyenbayeva Nadezhda - Gliomas are complex and among the most lethal central nervous system (CNS) disorders. While they are notoriously heterogeneous, evidences suggest critical involvement of intricate interactions between RNA-binding proteins (RBPs) and their diverse partners, in the pathogeneses of gliomas. In this study, we used RNA sequencing data from the Cancer Genome Atlas (TCGA) to identify differentially expressed genes (DEGs). After selection of differentially expressed RBPs from these DEGs, systematic investigation of their transcriptomic changes during glioma progression was undertaken. Extensive in silico assessments allowed the creation of their interactome and pathway, identifying potential biological effects of these differentially expressed RBPs. Construction of regulatory networks of these differentially expressed RBPs and their topological analysis discovered key RBPs such as PABPC1, EIF4A2, RPS3, EEF1A1, RPS6, ELAVL2, CPEB1, and CELF5, which are largely involved in alternative splicing and ribosomal biogenesis. Moreover, we also identified differentially expressed RBPs such as YBX1, ELAVL2, and IGF2BP1, which may be involved in the formation of stress granules in gliomas. We also identified highly mutated RBPs, such as RPSA, RPL5, CPEB4, and SMAD7, in gliomas. Further, RBPs like RPS8, RPL5, RPS3A, EEF1A1, and EIF4E1B were found to be strongly correlated with patients' overall survival. Taken together, our analyses identified several candidate RBPs which might serve as potential targets for oncological measures against gliomas. - Source: PubMed
Publication date: 2025/12/08
Haque ShafiulMathkor Darin MansorBabegi Ashjan SaeedAhmad FarazArumugam Mohanapriya - Non-alcoholic fatty liver disease (MASLD) affects approximately 32.4% of adults globally, progressing from simple steatosis to non-alcoholic steatohepatitis (MASH), cirrhosis, and hepatocellular carcinoma (HCC). Alternative splicing (AS) is crucial for gene expression regulation, and its dysregulation is linked to disease progression. To identify early molecular signatures indicative of cirrhosis in MASLD, we analyzed RNA sequencing data from liver tissues of healthy controls ( = 10), MASLD patients ( = 9), and cirrhosis patients ( = 10) obtained from the SRA database (accession ERP146053). Utilizing SUVA for splicing event detection and k-means clustering, we examined dynamic changes in alternative splicing events and constructed regulatory networks of RNA-binding proteins (RBPs). Integration with immunological profiles enabled us to explore the interplay between splicing variants and immune responses during disease progression. We identified 671 differential alternative splicing events. Clustering revealed dynamic splicing patterns across disease stages, with two key patterns associated with DNA damage response (DDR) and epithelial-mesenchymal transition (EMT) processes, showing early progressive alterations correlating with disease severity. Twelve immune-related splicing events were significantly associated with changes in immune cell populations, highlighting their role in immune regulation during Liver disease progression. Additionally, 11 RBPs, including CELF5 and PCBP1, showed expression changes that correlate with splicing events associated with MASLD progression. Identifying early alternative splicing signatures and understanding RBP networks enhance our ability to predict disease progression and present potential therapeutic targets for early intervention. - Source: PubMed
Publication date: 2025/11/19
Chen LiMa WeiHu YaoqingQin YaoZhao ShenghuiYang Jiayao