Ask about this productRelated genes to: BRUNOL5 antibody
- Gene:
- CELF5 NIH gene
- Name:
- CUGBP Elav-like family member 5
- Previous symbol:
- BRUNOL5
- Synonyms:
- -
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-28
- Date modifiied:
- 2017-01-20
Related products to: BRUNOL5 antibody
Related articles to: BRUNOL5 antibody
- This study evaluates the impact of a comprehensive remedial program within the "Literary Reading" curriculum on the spoken language development of deaf and hard-of-hearing children in grades 2-4, aligned with Kazakhstan's communicative paradigm of primary education. A total of 150 students aged 7-10 participated. The six-month intervention included interdisciplinary integration, auditory training, and spoken language reading strategies. The Clinical Evaluation of Language Fundamentals (adapted into Russian) was used for assessment. Linear mixed-effects models revealed significant Group × Time interactions across all CELF-5 indices, indicating substantially greater pre-to-post language gains in the experimental group compared to the control group. Significant effects were observed for the Core Language Score (β = -6.30, SE = 0.43, z = -14.72, < 0.001), Receptive Language Index (β = -5.17, SE = 0.36, z = -14.53, < 0.001), Expressive Language Index (β = -5.42, SE = 0.41, z = -13.22, < 0.001), Language Content Index (β = -5.03, SE = 0.40, z = -12.58, < 0.001), and Language Memory Index (β = -4.79, SE = 0.42, z = -11.41, < 0.001). While the control group showed only minimal developmental changes, the experimental group demonstrated pronounced improvements across all language domains. The findings support the effectiveness of the program in improving spoken language skills among children who are deaf or hard of hearing. Its success in Kazakhstan suggests potential for adaptation in other Russian-speaking educational contexts focused on corrective learning for children with special needs. - Source: PubMed
Publication date: 2026/03/23
Saurykova BaglanSaurykova KuralayYeleussizkyzy MeruyertZhiyenbayeva Nadezhda - Gliomas are complex and among the most lethal central nervous system (CNS) disorders. While they are notoriously heterogeneous, evidences suggest critical involvement of intricate interactions between RNA-binding proteins (RBPs) and their diverse partners, in the pathogeneses of gliomas. In this study, we used RNA sequencing data from the Cancer Genome Atlas (TCGA) to identify differentially expressed genes (DEGs). After selection of differentially expressed RBPs from these DEGs, systematic investigation of their transcriptomic changes during glioma progression was undertaken. Extensive in silico assessments allowed the creation of their interactome and pathway, identifying potential biological effects of these differentially expressed RBPs. Construction of regulatory networks of these differentially expressed RBPs and their topological analysis discovered key RBPs such as PABPC1, EIF4A2, RPS3, EEF1A1, RPS6, ELAVL2, CPEB1, and CELF5, which are largely involved in alternative splicing and ribosomal biogenesis. Moreover, we also identified differentially expressed RBPs such as YBX1, ELAVL2, and IGF2BP1, which may be involved in the formation of stress granules in gliomas. We also identified highly mutated RBPs, such as RPSA, RPL5, CPEB4, and SMAD7, in gliomas. Further, RBPs like RPS8, RPL5, RPS3A, EEF1A1, and EIF4E1B were found to be strongly correlated with patients' overall survival. Taken together, our analyses identified several candidate RBPs which might serve as potential targets for oncological measures against gliomas. - Source: PubMed
Publication date: 2025/12/08
Haque ShafiulMathkor Darin MansorBabegi Ashjan SaeedAhmad FarazArumugam Mohanapriya - Non-alcoholic fatty liver disease (MASLD) affects approximately 32.4% of adults globally, progressing from simple steatosis to non-alcoholic steatohepatitis (MASH), cirrhosis, and hepatocellular carcinoma (HCC). Alternative splicing (AS) is crucial for gene expression regulation, and its dysregulation is linked to disease progression. To identify early molecular signatures indicative of cirrhosis in MASLD, we analyzed RNA sequencing data from liver tissues of healthy controls ( = 10), MASLD patients ( = 9), and cirrhosis patients ( = 10) obtained from the SRA database (accession ERP146053). Utilizing SUVA for splicing event detection and k-means clustering, we examined dynamic changes in alternative splicing events and constructed regulatory networks of RNA-binding proteins (RBPs). Integration with immunological profiles enabled us to explore the interplay between splicing variants and immune responses during disease progression. We identified 671 differential alternative splicing events. Clustering revealed dynamic splicing patterns across disease stages, with two key patterns associated with DNA damage response (DDR) and epithelial-mesenchymal transition (EMT) processes, showing early progressive alterations correlating with disease severity. Twelve immune-related splicing events were significantly associated with changes in immune cell populations, highlighting their role in immune regulation during Liver disease progression. Additionally, 11 RBPs, including CELF5 and PCBP1, showed expression changes that correlate with splicing events associated with MASLD progression. Identifying early alternative splicing signatures and understanding RBP networks enhance our ability to predict disease progression and present potential therapeutic targets for early intervention. - Source: PubMed
Publication date: 2025/11/19
Chen LiMa WeiHu YaoqingQin YaoZhao ShenghuiYang Jiayao - This study aimed to investigate the language skills of children with Alexander disease (AxD) and determine whether disease subtypes and/or age contributes to variability in language performance. - Source: PubMed
Publication date: 2025/11/18
Levin DebraLevin JordanJoung JoshuaLiu Geraldine WDonaher JosephFaig WalterWaldman Amy T - Some children experience greater listening difficulties in noisy and reverberant environments than their peers, despite having normal peripheral hearing. In these cases, other potential causes have to be explored. One is a language disorder. Testing this possibility in audiology requires a language screening test that can be used by audiologists. This study aims to establish reference data for a screening test, the auditory cloze test (AudiCloze), to examine sex differences and to validate the results by comparing them with the standardized Clinical Evaluation of Language Fundamentals Fifth Edition (CELF-5) sentences recall test. Finally, the study examines the relationship between children's language skills-a composite of the new auditory cloze test and sentences recall-and their abilities to listen in noise and reverberation within a representative sample. - Source: PubMed
Publication date: 2025/09/01
Zhou XuehanDillon HarveyTomlin DaniBurgoyne KellyGurteen HelenNixon GraceGudkar Alisha IsaacHeinrich Antje