Ask about this productRelated genes to: ADAD2 antibody
- Gene:
- ADAD2 NIH gene
- Name:
- adenosine deaminase domain containing 2
- Previous symbol:
- -
- Synonyms:
- TENRL, FLJ00337
- Chromosome:
- 16q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 2007-05-31
- Date modifiied:
- 2014-11-19
Related products to: ADAD2 antibody
Related articles to: ADAD2 antibody
- One of the main challenges in Type 1 diabetes mellitus (T1DM) research is the sample size of the participants and the invasive process of collecting an adequate number of blood samples from young patients with T1DM. Therefore, it is of great interest to investigate the possibility of using saliva as a non-invasive tool to investigate the genetic factors that are associated with T1DM comorbidities. The present study aims to identify differentially expressed genes (DEGs) in saliva samples of T1DM patients with various comorbidities using transcriptomic profiling. - Source: PubMed
Publication date: 2025/10/10
Mussa Bashair MSrivastava AnkitaRajan ReejaVenkatachalam ThenmozhiAl-Habshi AbeerAbdelgadir ElaminBashier AlaaeldinAl Awadi FatheyaHafidh KhadijaHamoudi RifatAbusnana Salah - Spermatogenic failure is one of the leading causes of male infertility and its genetic etiology has not yet been fully understood. - Source: PubMed
Publication date: 2024/09/12
Zhou HaiyanYin ZhaochuNi BinLin JiwuLuo ShuweiXie Wanqin - This study intended to develop a new immunogenic cell death (ICD)-related prognostic signature for colorectal cancer (CRC) patients. - Source: PubMed
Publication date: 2024/02/26
Lei JunpingFu JiaWang TianyangGuo YuGong MingminXia TianShang SongXu YanCheng LingLin Binghu - - Source: PubMed
Publication date: 2023/12/18
Chukrallah Lauren GBadrinath AditiVittor Gabrielle GSnyder Elizabeth M - Mammalian male germ cell differentiation relies on complex RNA biogenesis events, many of which occur in non-membrane bound organelles termed RNA germ cell granules that are rich in RNA binding proteins (RBPs). Though known to be required for male germ cell differentiation, we understand little of the relationships between the numerous granule subtypes. ADAD2, a testis specific RBP, is required for normal male fertility and forms a poorly characterized granule in meiotic germ cells. This work aimed to understand the role of ADAD2 granules in male germ cell differentiation by clearly defining their molecular composition and relationship to other granules. Biochemical analyses identified RNF17, a testis specific RBP that forms meiotic male germ cell granules, as an ADAD2-interacting protein. Phenotypic analysis of Adad2 and Rnf17 mutants identified a rare post-meiotic chromatin defect, suggesting shared biological roles. ADAD2 and RNF17 were found to be dependent on one another for granularization and together form a previously unstudied set of germ cell granules. Based on co-localization studies with well-characterized granule RBPs and organelle-specific markers, a subset of the ADAD2-RNF17 granules are found to be associated with the intermitochondrial cement and piRNA biogenesis. In contrast, a second, morphologically distinct population of ADAD2-RNF17 granules co-localized with the translation regulators NANOS1 and PUM1, along with the molecular chaperone PDI. These large granules form a unique funnel-shaped structure that displays distinct protein subdomains and is tightly associated with the endoplasmic reticulum. Developmental studies suggest the different granule populations represent different phases of a granule maturation process. Lastly, a double Adad2-Rnf17 mutant model suggests the interaction between ADAD2 and RNF17, as opposed to loss of either, is the likely driver of the Adad2 and Rnf17 mutant phenotypes. These findings shed light on the relationship between germ cell granule pools and define new genetic approaches to their study. - Source: PubMed
Publication date: 2023/07/10
Chukrallah Lauren GPotgieter SarahChueh LisaSnyder Elizabeth M