Ask about this productRelated genes to: ERAL1 antibody
- Gene:
- ERAL1 NIH gene
- Name:
- Era like 12S mitochondrial rRNA chaperone 1
- Previous symbol:
- -
- Synonyms:
- HERA-B
- Chromosome:
- 17q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-11-19
- Date modifiied:
- 2016-03-31
Related products to: ERAL1 antibody
Related articles to: ERAL1 antibody
- Mitochondrial GTPase ERA G-protein-like 1 (ERAL1) is considered an antiviral host factor against RNA viruses. However, its role in driving DNA virus infection, particularly hepatitis B virus (HBV) infection, and its relevance to human liver disease are unknown. This study aimed to define the function and molecular mechanism of ERAL1 in HBV pathogenesis. - Source: PubMed
Publication date: 2026/06/16
Lin CaoruiZheng XiaosangChen KaixinRan NingLuo LinjieZhang XinHuang YingZhang JiaweiZhu HanyongHe JieyingYang BinOu QishuiLiu Can - Perrault syndrome is a genetically and clinically diverse autosomal recessive disorder characterized by sensorineural hearing loss in both sexes and primary ovarian insufficiency in females. This comprehensive review synthesizes data from various studies to map the genetic architecture of Perrault syndrome, highlighting mutations in fifteen principal genes: HSD17B4, HARS2, CLPP, LARS2, TWNK, ERAL1, RMND1, DAP3, PRORP, MRPL50, MRPL49, MRPS7, PEX6, GGPS1, and TFAM. Each of these genes plays a critical role either in mitochondrial function or peroxisomal processes, central to cellular energy metabolism and biosynthesis pathways. The review not only documents the spectrum of mutations found within these genes but also correlates specific genetic alterations with the range of phenotypes observed in patients, emphasizing the syndrome's allelic, locus, and clinical heterogeneity. The cohort demonstrates a distribution of 56.1% homozygous and 43.9% compound heterozygous variants, reflecting diverse ancestral backgrounds and potential selective pressures against deleterious alleles. The findings underscore the necessity for advanced genetic screening techniques in accurate diagnosis and the potential for gene-specific therapies that may mitigate some of the clinical manifestations of this complex condition. - Source: PubMed
Publication date: 2026/06/12
Tlili AbdelazizKhudeir Joudi Feras - Hepatocellular carcinoma (HCC) is a highly aggressive malignancy of the digestive system characterized by increasing global incidence and mortality rates. Translocase of the Inner Mitochondrial Membrane 23 (TIMM23), a key component of the mitochondrial inner membrane translocase complex, plays a critical role in the import and localization of mitochondrial proteins. Elevated TIMM23 expression is significantly associated with poor prognosis in patients with HCC Conversely, TIMM23 downregulation was found to have induced apoptosis and significantly inhibited the proliferation, migration, and invasive potential of HCC cells both in vitro and in vivo. Furthermore, we have identified the functional interplay between TIMM23 and ERA G-protein-like 1 (ERAL1). TIMM23 knockdown markedly altered mitochondrial membrane potential and permeability, leading to a subsequent decrease in ERAL1 expression. ERAL1 interacts with Bcl-2-like protein 1 (Bcl-XL) during apoptosis. These findings collectively underscore the pivotal role of the TIMM23-ERAL1 axis in HCC progression, suggesting that the therapeutic targeting of TIMM23 may offer a promising strategy for HCC treatment. - Source: PubMed
Publication date: 2026/03/28
Chen YihongQian QiyiLi JuejiashanHu SiweiWen YutingTu LinglanTan LiangtingChen WenhuWang LifangFang YuliangJiang WangxinruiXu QiuranHuang DongshengLi Xiaoyan
- Source: PubMed
- Ribosome biogenesis (RiboSis) is a complex process for generating ribosomes, the cellular machinery responsible for protein synthesis. Dysfunctional RiboSis can disrupt cardiac structure and function, contributing to cardiovascular diseases. This study employed a Mendelian randomization (MR) approach, integrating multi-omics data, to investigate the relationship between RiboSis-related genes and standard cardiac structure and function. - Source: PubMed
Publication date: 2025/03/05
Wei ShuxuShen RonghuaiLu XiaojiaLi XinyiHe LingbinZhang YoutiYang JiahangShu ZhouwuHuang Xianxi