Ask about this productRelated genes to: RBPMS antibody
- Gene:
- RBPMS NIH gene
- Name:
- RNA binding protein, mRNA processing factor
- Previous symbol:
- -
- Synonyms:
- HERMES
- Chromosome:
- 8p12
- Locus Type:
- gene with protein product
- Date approved:
- 2003-02-25
- Date modifiied:
- 2018-01-04
Related products to: RBPMS antibody
Related articles to: RBPMS antibody
- Leukemia is a malignant tumor with a high recurrence rate and poor prognosis for patients. Thus, there is an urgent need to explore new therapeutic targets that play critical roles in leukemogenesis but have little effect on normal hematopoietic cells. Here, we show that RNA binding protein with multiple splicing (RBPMS), which is highly expressed in acute myeloid leukemia (AML) and associated with poor prognosis of AML, plays critical roles in leukemogenesis. Our study shows that inhibition of RBPMS inhibits self-renewal of leukemia-initiating cells (LICs) and leukemia development but has little effect on normal hematopoiesis. Mechanistically, RBPMS recruits the -methyladenosine (mA) reader insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3), which promotes the stability of the () mRNA in an mA-dependent manner. Moreover, RBPMS contributes to the progression of leukemia by directly binding to and promoting FOXO1-regulated glycolysis. Overexpression of FOXO1 has been shown to reverse RBPMS inhibition-induced phenotypes in both leukemic cells and mouse models. We also designed a specific inhibitor of RBPMS that has therapeutic effects in AML patient-derived xenograft (PDX) models. We therefore highlight RBPMS as a promising drug target for leukemia therapy. - Source: PubMed
Publication date: 2026/05/06
Liu PingZhang SulinChen Bing-YiChang BinheJiang YilunLi XiyaChen XinchiLi Zi-JuanYang RuiruiWang XiaoningXu Chun-HuiLiu XiaomengLiu NaJia YuanyuanYu Peng-ChengWang YongZong Li-JuanHu Cheng-LongHou HuiCao DuanhuaLi XutongDeng Chu-HanRen Yi-YiZhao Mu-YingMa XinyiCui RongrongTeng DanChen MiaoWang RoujiaJin JiachengJiang Shi-YuYan XiaojingXue KaiZhang QunlingLi JianfengDai EnyongShen ShuhongWang ZhikaiYe XueshiZhang JinLiu YuCui WenguoLu MinZhao Wei-LiChang Chun-KangHe Peng-ChengChen ZhuChen Sai-JuanZheng MingyueSun Xiao-JianWang Lan - This study examines whether the response of the rat optic nerve tissue to either acute or chronic intraocular pressure (IOP) elevation is affected when optic nerve sheath pressure is reduced via optic nerve sheath fenestration. - Source: PubMed
Ganearachchi Sera NZhao DaWong Vickie H YLee Pei YingAfiat Brianna CNguyen Christine T OBui Bang V - The Cre/loxP recombination system is the main tool for cell type-specific lineage tracing and gene targeting. Currently available smooth muscle cell (SMC)-specific Cre mouse lines show off-target activity outside the SMC lineage and are unable to distinguish among arterial SMCs (ASMCs), venous SMCs, and nonvascular SMCs (NVSMCs). These limitations prevent ASMC- and NVSMC-specific gene targeting, which is required to characterize the role of SMCs in different organs and diseases. - Source: PubMed
Publication date: 2026/04/13
Wang LeiStaps MaximilianGünther StefanEl Agha ElieBellusci SaverioKuenne CarstenDu JunhuaSchneider AndreBraun Thomas - Diabetic retinopathy (DR) is one of the primary causes of vision impairment, affecting individuals with diabetes, and is marked by the neurodegeneration of the retina along with increased intraocular pressure (IOP). This study sought to determine the effects of pelargonidin on extracellular matrix (ECM) modulation and the inhibition of transforming growth factor-β (TGF-β) and Janus Kinase 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) pathway in retinal ganglion cells of streptozotocin-induced diabetic rats. Male Sprague-Dawley rats (180-200 g) were rendered diabetic by intraperitoneal administration of streptozotocin (STZ). The rats were divided into 5 groups: control, diabetic model (STZ), STZ + low dose pelargonidin (12.5 mg kg per day), STZ + medium dose pelargonidin (25 mg kg-1 per day) and STZ + high dose pelargonidin (50 mg kg per day). IOP was monitored using a tonometer. Whole-mount retinal immunofluorescence staining using RNA-binding protein with multiple splicing (RBPMS) was performed to assess retinal ganglion cell (RGC) density. Protein expression levels of apoptotic markers, ECM components, and TGF-β and JAK2/STAT3 signalling pathways were evaluated by Western blotting. Pelargonidin treatment dose-dependently reduced the elevated IOP. Importantly, immunofluorescence analysis revealed a marked dose-dependent preservation of retinal ganglion cell (RGC) density: STZ-induced RGC loss was significantly reversed by pelargonidin, with the highest dose restoring RGC density to near-control or higher levels in both the central and peripheral retina. This was achieved modulation of apoptosis-related proteins through the upregulation of Bcl-xL, Bcl-2, and downregulation of Bad, Bax and cleaved caspase-3. Furthermore, pelargonidin modulated ECM remodelling protein expression in the RGC layer. In particular, TGF-β2/Smad2/3 signalling was downregulated, and the JAK2/STAT3 pathway was upregulated. By reducing IOP, preserving RGC density, modulating ECM deposition, inhibiting TGF-β and upregulating the JAK2/STAT3 pathway, pelargonidin exerts protective effects against diabetic retinal injury. The results of this study further confirm the pharmacological potential of pelargonidin as a therapeutic agent for diabetic retinopathy. - Source: PubMed
Publication date: 2026/04/09
Yu HaichunAlbrakati AshrafWani Ejaz AkbarLi Ying - To characterize the cellular tropism and temporal dynamics of adeno-associated virus 2 (AAV2)-retro-mediated gene delivery in the adult mouse retina following intravitreal injection. - Source: PubMed
Publication date: 2026/03/12
Kinane ChaimaaPanchal MoxaTsoulfas PantelisTalla VenuPark Kevin K