Ask about this productRelated genes to: CPSF1 antibody
- Gene:
- CPSF1 NIH gene
- Name:
- cleavage and polyadenylation specific factor 1
- Previous symbol:
- -
- Synonyms:
- CPSF160
- Chromosome:
- 8q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-31
- Date modifiied:
- 2017-05-08
- Gene:
- CPSF2 NIH gene
- Name:
- cleavage and polyadenylation specific factor 2
- Previous symbol:
- -
- Synonyms:
- KIAA1367, CPSF100
- Chromosome:
- 14q32.12
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-31
- Date modifiied:
- 2017-05-08
Related products to: CPSF1 antibody
Related articles to: CPSF1 antibody
- Alternative polyadenylation (APA) plays a vital regulatory role in various diseases. It is widely accepted that APA is regulated by APA regulatory factors. - Source: PubMed
Publication date: 2024/04/12
Wang XiaoyuLin YaoLi ZhengLi YueqiChen Mingcong - The eukaryotic translation initiation factor eIF4E is nuclear and cytoplasmic where it plays roles in export and translation of specific transcripts, respectively. When we were studying its mRNA export activity, we unexpectedly discovered that eIF4E drives the protein expression of elements of the 3'-end core cleavage complex involved in cleavage and polyadenylation (CPA), including CPSF3, the enzyme responsible for cleavage, as well as its co-factors CPSF1, CPSF2, CPSF4, Symplekin, WDR33, and FIP1L1. Using multiple strategies, we demonstrate that eIF4E stimulates 3'-end cleavage of selected RNAs. eIF4E physically interacts with CPSF3, CPSF1, and uncleaved target RNA, suggesting it acts directly and indirectly on the pathway. Through these effects, eIF4E can generate better substrates for its mRNA export and translation activities. Thus, we identified an unanticipated function for eIF4E in 3'-end processing of specific target RNAs, and this function could potentially affect the expression of a broad range of oncoproteins. - Source: PubMed
Davis Margaret RoseDelaleau MildredBorden Katherine L B