Ask about this productRelated genes to: ERAL1 antibody
- Gene:
- ERAL1 NIH gene
- Name:
- Era like 12S mitochondrial rRNA chaperone 1
- Previous symbol:
- -
- Synonyms:
- HERA-B
- Chromosome:
- 17q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-11-19
- Date modifiied:
- 2016-03-31
Related products to: ERAL1 antibody
Related articles to: ERAL1 antibody
- Hepatocellular carcinoma (HCC) is a highly aggressive malignancy of the digestive system characterized by increasing global incidence and mortality rates. Translocase of the Inner Mitochondrial Membrane 23 (TIMM23), a key component of the mitochondrial inner membrane translocase complex, plays a critical role in the import and localization of mitochondrial proteins. Elevated TIMM23 expression is significantly associated with poor prognosis in patients with HCC Conversely, TIMM23 downregulation was found to have induced apoptosis and significantly inhibited the proliferation, migration, and invasive potential of HCC cells both in vitro and in vivo. Furthermore, we have identified the functional interplay between TIMM23 and ERA G-protein-like 1 (ERAL1). TIMM23 knockdown markedly altered mitochondrial membrane potential and permeability, leading to a subsequent decrease in ERAL1 expression. ERAL1 interacts with Bcl-2-like protein 1 (Bcl-XL) during apoptosis. These findings collectively underscore the pivotal role of the TIMM23-ERAL1 axis in HCC progression, suggesting that the therapeutic targeting of TIMM23 may offer a promising strategy for HCC treatment. - Source: PubMed
Publication date: 2026/03/28
Chen YihongQian QiyiLi JuejiashanHu SiweiWen YutingTu LinglanTan LiangtingChen WenhuWang LifangFang YuliangJiang WangxinruiXu QiuranHuang DongshengLi Xiaoyan
- Source: PubMed
- Ribosome biogenesis (RiboSis) is a complex process for generating ribosomes, the cellular machinery responsible for protein synthesis. Dysfunctional RiboSis can disrupt cardiac structure and function, contributing to cardiovascular diseases. This study employed a Mendelian randomization (MR) approach, integrating multi-omics data, to investigate the relationship between RiboSis-related genes and standard cardiac structure and function. - Source: PubMed
Publication date: 2025/03/05
Wei ShuxuShen RonghuaiLu XiaojiaLi XinyiHe LingbinZhang YoutiYang JiahangShu ZhouwuHuang Xianxi - Onco-immunotherapy via blocking checkpoint inhibitors has revolutionized the treatment-landscape of several malignancies, though not in the metastatic castration-resistant prostate cancer (PCa) owing to an immunosuppressive and poorly immunogenic "cold" tumor microenvironment (TME). Turning up the heat of such a cold TME via triggering innate immunity is now of increasing interest to restore immune-surveillance. Retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) are cytosolic innate-sensors that can detect exogenous RNAs and induce type-I interferons and other pro-inflammatory signaling. RIG-I activation is suggested to be a valuable addition to the treatment approaches for several cancers. However, the knowledge about RIG-I signaling in PCa remains elusive. The present study evaluated the expression of two important RLRs, RIG-I and melanoma differentiation-associated protein 5 (MDA5), along with their downstream partners, mitochondrial antiviral-signaling protein (MAVS) and ERA G-protein-like 1 (ERAL1), during PCa progression in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. The early stage of PCa revealed a significant increment in the expression of RLRs but not MAVS. However, the advanced stage showed downregulated RLR signaling. Further, the therapeutic implication of 5'ppp-dsRNA, a synthetic RIG-I agonist and Bcl2 gene silencer, has been investigated in vitro and in vivo. Intra-tumoral delivery of 5'ppp-dsRNA regressed tumor growth via triggering tumor cell apoptosis, immunomodulation, and inducing phagocytic "eat me" signals. These findings highlight that, for the first time, RIG-I activation and Bcl-2 silencing with 5'ppp-dsRNA can serve as a potent tumor-suppressor strategy in PCa and has a significant clinical implication in transforming a "cold" TME into an immunogenic "hot" TME of PCa. - Source: PubMed
Ganguly KasturiMetkari Siddhanath MBiswas BarnaliSubedi RambhadurMadan Taruna - The liver plays a vital role in lipid synthesis and metabolism in poultry. To study the functional genes more effectively, it is essential to screen of reliable reference genes in the chicken liver, including females, males, embryos, as well as the Leghorn Male Hepatoma (LMH) cell line. Traditional reference gene screening involves selecting commonly used housekeeping genes (HKGs) for RT-qPCR experiments and using different algorithms to identify the most stable ones. However, this approach is limited in selecting the best reference gene from a small pool of HKGs. High-throughput sequencing technology may offer a solution to this limitation. This study aimed to identify the most consistently expressed genes by utilizing multiple published RNA-seq data of chicken liver and LMH cells. Subsequently, the stability of the newly identified reference genes was assessed in comparison to previously validated stable poultry liver expressed reference genes and the commonly employed HKGs using RT-qPCR. The findings indicated that there is a higher degree of similarity in stable expression genes between female and male liver (such as LSM14A and CDC40). In embryonic liver, the optimal new reference genes were SUDS3, TRIM33, and ERAL1. For LMH cells, the optimal new reference genes were ALDH9A1, UGGT1, and C21H1orf174. However, it is noteworthy that most HKGs did not exhibit stable expression across multiple samples, indicating potential instability under diverse conditions. Furthermore, RT-qPCR experiments proved that the stable expression genes identified from RNA-seq data outperformed commonly used HKGs and certain validated reference genes specific to poultry liver. Over all, this study successfully identified new stable reference genes in chicken liver and LMH cells using RNA-seq data, offering researchers a wider range of reference gene options for RT-qPCR in diverse situations. - Source: PubMed
Publication date: 2024/08/01
Chen ZiweiHua GuoyingShu XinZhuang WuchaoZhang JilongZhu RunbangZheng XiaotongChen Jianfei