Ask about this productRelated genes to: RBMY1A1 antibody
- Gene:
- RBMY1A1 NIH gene
- Name:
- RNA binding motif protein, Y-linked, family 1, member A1
- Previous symbol:
- RBM1, RBM2
- Synonyms:
- YRRM1, YRRM2
- Chromosome:
- Yq11.223
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-15
- Date modifiied:
- 2017-09-15
Related products to: RBMY1A1 antibody
Related articles to: RBMY1A1 antibody
- Studies of cell-to-cell activities in the tumor microenvironment (TME) have identified multiple potential targets for oncotherapy. The interplay between tumor cells and neighboring cancer-associated fibroblasts (CAFs) persists in all stages of tumor progression. In this study, we reveal that exosomes from breast cancer cells can be endocytosed into fibroblasts and transform normal fibroblasts (NFs) into CAFs and that the ability of exosomes from highly metastatic breast cancer cells is greater than that of those from poorly metastatic breast cancer cells. Further investigation reveals that exosomes from highly metastatic breast cancer cells contain much more miR-105-5p than those from poorly metastatic breast cells do and that exosomal miR-105-5p facilitates the transformation of NFs to CAFs. A detailed study reveals that RBMY1A1-dependent sorting of miR-105-5p into fibroblasts and subsequent internalization of miR-105-5p promote the transformation of NFs to CAFs by downregulating LATS2 expression and activating NF-κB signaling, which concurrently facilitates the EMT of breast cancer cells. Thus, our results indicate that exosomal miR-105-5p may be a potential target for novel therapeutic strategies to prevent the coevolution of breast cancer cells and CAFs. - Source: PubMed
Ding XiaodiSheng ZhimeiCui JiayuCui MeimeiZhang LiyingFeng RuijunWang YongmingSun WeiZhang XiurongShi LihongZhang Baogang - The human Y chromosome has been notoriously difficult to sequence and assemble because of its complex repeat structure that includes long palindromes, tandem repeats and segmental duplications. As a result, more than half of the Y chromosome is missing from the GRCh38 reference sequence and it remains the last human chromosome to be finished. Here, the Telomere-to-Telomere (T2T) consortium presents the complete 62,460,029-base-pair sequence of a human Y chromosome from the HG002 genome (T2T-Y) that corrects multiple errors in GRCh38-Y and adds over 30 million base pairs of sequence to the reference, showing the complete ampliconic structures of gene families TSPY, DAZ and RBMY; 41 additional protein-coding genes, mostly from the TSPY family; and an alternating pattern of human satellite 1 and 3 blocks in the heterochromatic Yq12 region. We have combined T2T-Y with a previous assembly of the CHM13 genome and mapped available population variation, clinical variants and functional genomics data to produce a complete and comprehensive reference sequence for all 24 human chromosomes. - Source: PubMed
Publication date: 2023/08/23
Rhie ArangNurk SergeyCechova MonikaHoyt Savannah JTaylor Dylan JAltemose NicolasHook Paul WKoren SergeyRautiainen MikkoAlexandrov Ivan AAllen JamieAsri MobinBzikadze Andrey VChen Nae-ChyunChin Chen-ShanDiekhans MarkFlicek PaulFormenti GiulioFungtammasan ArkarachaiGarcia Giron CarlosGarrison ErikGershman ArielGerton Jennifer LGrady Patrick G SGuarracino AndreaHaggerty LeanneHalabian RezaHansen Nancy FHarris RobertHartley Gabrielle AHarvey William THaukness MarinaHeinz JakobHourlier ThibautHubley Robert MHunt Sarah EHwang StephenJain MitenKesharwani Rupesh KLewis Alexandra PLi HengLogsdon Glennis ALucas Julian KMakalowski WojciechMarkovic ChristopherMartin Fergal JMc Cartney Ann MMcCoy Rajiv CMcDaniel JenniferMcNulty Brandy MMedvedev PaulMikheenko AllaMunson Katherine MMurphy Terence DOlsen Hugh EOlson Nathan DPaulin Luis FPorubsky DavidPotapova TamaraRyabov FedorSalzberg Steven LSauria Michael E GSedlazeck Fritz JShafin KishwarShepelev Valery AShumate AlainaStorer Jessica MSurapaneni LikhithaTaravella Oill Angela MThibaud-Nissen FrançoiseTimp WinstonTomaszkiewicz MartaVollger Mitchell RWalenz Brian PWatwood Allison CWeissensteiner Matthias HWenger Aaron MWilson Melissa AZarate SamanthaZhu YimingZook Justin MEichler Evan EO'Neill Rachel JSchatz Michael CMiga Karen HMakova Kateryna DPhillippy Adam M - Rev7 is a versatile HORMA (Hop1, Rev7, Mad2) family adaptor protein with multiple roles in mitotic regulation and DNA damage response, and an essential accessory subunit of the translesion synthesis (TLS) DNA polymerase Polζ employed in replication of damaged DNA. Within Polζ, the two copies of Rev7 interact with the two Rev7-bonding motifs (RBM1 and RBM2) of the catalytic subunit Rev3 by a mechanism characteristic of HORMA proteins whereby the "safety-belt" loop of Rev7 closes on the top of the ligand. Here we report the nearly complete backbone and Ile, Val, Leu side-chain methyl NMR resonance assignments of the 27 kDa human Rev7/Rev3-RBM1 and Rev7/Rev3-RBM2 complexes (BMRB deposition numbers 51651 and 51652) that will facilitate future NMR studies of Rev7 dynamics and interactions. - Source: PubMed
Publication date: 2023/05/02
Arianna Gianluca AGeddes-Buehre Dane HKorzhnev Dmitry M - Metastasis indicates a grave prognosis in patients with hepatocellular carcinoma (HCC). Our previous studies showed that RNA binding motif protein Y-linked (RBMY) is potentially a biomarker for poor survival in HCC patients, but its role in metastasis is largely unclear. - Source: PubMed
Publication date: 2022/10/01
Chua Huey-HueyChang Mei-HweiChen Ya-HuiTsuei Daw-JenJeng Yung-MingLee Po-HuangNi Yen-Hsuan - The human Y chromosome harbors genes that are mainly involved in the growth, development, sexual dimorphism, and spermatogenesis process. Despite many studies, the function of the male-specific region of the Y chromosome (MSY) awaits further clarification, and a cell-based approach can help in this regard. - Source: PubMed
Publication date: 2022/06/03
Khani FarzanehNafian SiminMollamohammadi SepidehNemati ShivaShokoohian BahareHassani Seyedeh NafisehBaharvand HosseinSoleimanpour-Lichaei Hamid RezaSalekdeh Ghasem Hosseini