Ask about this productRelated genes to: DHX32 antibody
- Gene:
- DHX32 NIH gene
- Name:
- DEAH-box helicase 32 (putative)
- Previous symbol:
- DDX32
- Synonyms:
- FLJ10889, FLJ10694, DHLP1
- Chromosome:
- 10q26.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-11-27
- Date modifiied:
- 2018-06-26
Related products to: DHX32 antibody
Related articles to: DHX32 antibody
- The second deadliest cancer in the world is colorectal cancer (CRC), which is caused by the uncontrolled proliferation of epithelial cells in the colon. This research examines the role of key genes-including tumor suppressors ING4 and APC, angiogenesis-related DHX32, and the oncogenic mutated P53-in the SW480 cell line. Probiotics and their exopolysaccharide (EPS) component show potential in cancer prevention and treatment due to their antioxidant and anti-cancer properties. Zinc oxide nanoparticles (ZnONPs), recognized for their unique physical and chemical characteristics, have broad applications in drug delivery, cancer diagnostics, and therapy. In this project, EPS was extracted from Lactiplantibacillus plantarum and used for ZnONPs biosynthesis, followed by characterization through UV-VIS, XRD, FTIR, FE-SEM, and zeta potential analysis. Cytotoxic effects of EPS and ZnONPs were evaluated on SW480 cells, along with their antioxidant properties. Quantitative real-time PCR analysis revealed decreased expression of DHX32 and P53, while ING4 and APC gene expression increased following treatment of the cancerous cell line with target agents. These findings suggest that probiotic-derived EPS and ZnONPs may offer effective strategies for CRC treatment by modulating critical gene expression involved in disease progression. - Source: PubMed
Publication date: 2025/09/29
Afsharipoor SaeidehNazari RaziehEghdami AnooshFasihi-Ramandi MahdiZolfaghari Mohammad Reza - Transcription factor 19 (TCF19) is considered a crucial transcription factor and acts as an oncogene in a few cancers. Nevertheless, the effect and mechanism of TCF19 on glioma remain unknown. - Source: PubMed
Tan JingLian HaipingZheng QiYang TingtingWang Tuo - [This corrects the article DOI: 10.21037/tcr.2020.02.35.]. - Source: PubMed
- Studies showed that the gastrointestinal (GI) tract is one of the most important pathways for SARS-CoV-2 infection and coronavirus disease 2019 (COVID-19). As SARS-CoV-2 cellular entry depends on the ACE2 receptor and TMPRSS2 priming of the spike protein, it is important to understand the molecular mechanisms through which these two proteins and their cognate transcripts interact and influence the pathogenesis of COVID-19. In this study, we quantified the expression, associations, genetic modulators, and molecular pathways for and mRNA expressions in GI tissues using a systems genetics approach and the expanded family of highly diverse BXD mouse strains. The results showed that both and are highly expressed in GI tissues with significant covariation. We identified a significant expression quantitative trait locus on chromosome 7 that controls the expression of both and . was found to be the strongest candidate in this interval. Co-expression network analysis demonstrated that both and were located at the same module that is significantly associated with other GI-related traits. Protein-protein interaction analysis indicated that hub genes in this module are linked to circadian rhythms. Collectively, our data suggested that genes with circadian rhythms of expression may have an impact on COVID-19 disease, with implications related to the timing and treatment of COVID-19. - Source: PubMed
Publication date: 2021/11/16
Xu FuyiGao JunOrgil Buyan-OchirBajpai Akhilesh KumarGu QingqingPurevjav EnkhsaikhanDavenport Athena SLi KuiTowbin Jeffrey ABlack Dennis DPierre Joseph FLu Lu - DEAH-box helicase 32 (DHX32) is an RNA helicase with unique structural characteristics that is involved in numerous biological processes associated with RNA, including ribosome biosynthesis, transcription, mRNA splicing and translation. Increasing evidence suggests that abnormal DHX32 expression contributes to cancer initiation and development, due to dysregulated cell proliferation, differentiation, apoptosis and other processes. In the current review, the discovery, structure and function of DHX32, as well as the association between abnormal DHX32 expression and tumors are discussed. DHX32 expression is downregulated in acute lymphoblastic leukemia, but upregulated in solid tumors, including colorectal and breast cancer. Furthermore, DHX32 expression levels are associated with the pathological and clinical features of the cancer. Therefore, DHX32 may serve as a novel liquid biopsy marker for auxiliary diagnosis and prognosis screening, as well as a possible target for cancer therapy. The molecular mechanism underlying the contribution of DHX32 towards the initiation and development of cancer requires further investigation for the development of anticancer treatments based on manipulating DHX32 expression and function. - Source: PubMed
Publication date: 2021/03/16
Wei QingchunGeng JintingChen YongquanLin HuayueWang JiajiaFang ZanxiWang FenZhang Zhongying