Ask about this productRelated genes to: BRUNOL4 antibody
- Gene:
- CELF4 NIH gene
- Name:
- CUGBP Elav-like family member 4
- Previous symbol:
- BRUNOL4
- Synonyms:
- -
- Chromosome:
- 18q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-28
- Date modifiied:
- 2017-01-20
Related products to: BRUNOL4 antibody
Related articles to: BRUNOL4 antibody
- - Source: PubMed
Publication date: 2026/04/24
Li YigeQiu SiyuWang FangBi ZhenghongLiu ZhiyongHe YingziLi Geng-Lin - The rising global incidence of endometrial cancer (EC) necessitates the development of non-invasive, accurate detection methods to improve early diagnosis and optimize referrals for hysteroscopy. This study evaluated the diagnostic and triage value of a CDO1 and CELF4 methylation (CISENDO) assay using cervical scrapings for EC detection, and its independent association with EC across menopausal statuses. - Source: PubMed
Publication date: 2026/02/14
Wang XiuzhenZheng LangZhu GenhaiWang ShengtanLi WeiLiu JunGao HaochengLiu XiaohangLi GuifeiLi LeiHong Lan - Endometrial cancer (EC) is one of the most common gynecological cancers worldwide, with a rising incidence that highlights the urgent need for effective screening methods. Despite early-stage diagnosis and favorable survival rates, current screening methods such as transvaginal ultrasonography lack specificity, often necessitating invasive procedures and revealing a significant gap in EC detection. - Source: PubMed
Publication date: 2026/02/04
Hu MengjunKang LingHuang LiujingWang SiqiWu HangfeiBian YuehuanHe LiqunWang Hanmei - Currently, no non-invasive detection method for endometrial cancer (EC) is recommended in clinical practice worldwide. This study aimed to evaluate the clinical value of detecting DNA methylation of CDO1 and CELF4 (CDO1m/CELF4m) in exfoliated cervical cells for the detection of EC in women with suspected endometrial lesions. A total of 2164 patients scheduled for hysteroscopic surgery due to suspected endometrial lesions at the Obstetrics and Gynecology Hospital of Fudan University between July 2023 and May 2024 were prospectively enrolled. Preoperative exfoliated cervical cells were collected for dual-gene methylation testing. Clinical data and endometrial thickness measured by transvaginal sonography (TVS) were recorded. Hysteroscopic histopathological diagnosis served as the gold standard to evaluate the performance of methylation testing alone and in combination with TVS. This study included 2164 patients, comprising 33 EC cases, 31 cases of endometrial intraepithelial neoplasia (EIN), and 2100 cases of non-endometrial lesions, with mean ages of 51.7 ± 6.4, 49.5 ± 8.9, and 44.7 ± 9.8 years, respectively ( < 0.001). For EC detection, CDO1m/CELF4m positivity showed a sensitivity of 93.94% (95% CI: 79.77-99.26%), specificity of 96.7% (95% CI: 95.92-97.47%), positive predictive value (PPV) of 31.0% (95% CI: 25.96-36.53%), and negative predictive value (NPV) of 99.90% (95% CI: 99.63-99.98%). For EIN detection, the sensitivity was 83.87%, specificity 97.95%, PPV 37.68%, and NPV 99.76%. Combining TVS with DNA methylation detection further improved the sensitivity and NPV for both EC and EIN detection. DNA methylation detection in exfoliated cervical cells demonstrates high sensitivity and specificity for EC detection. The combination with TVS further enhances sensitivity and NPV, offering a simple and non-invasive triage strategy for patients with suspected endometrial lesions. This study was registered in China Clinical Trial Registry (ChiCTR2200055991) on 30 January 2023. - Source: PubMed
Publication date: 2026/01/06
Yu YiSu TingtingZhang HongweiLi QingCong QingSui LongChen Limei - Migraine is a neurovascular disorder that poses a high burden to Veterans, who face a greater risk than sex-matched individuals in the general population. Genetic research on migraine in Veterans and its link to psychiatric comorbidities is limited. We present a meta-analysis of a genome-wide association study (GWAS) of migraine in a predominantly male sample of over 433,000 Veterans, including 87,859 cases, from the Million Veteran Program (MVP), identifying 49 genome-wide significant loci, with 36 novel to this study, of which 7 replicated in an independent prior GWAS (after Bonferroni correction for number of loci tested). Our analyses revealed 283 genes, including some newly associated with migraine: MAML3, CELF4, IRX1, ASXL1, SPOCD1, CXCL, and TLR4. In silico analyses showed enrichment in brain and uterine tissues, which may reflect broader hormonal or neuroendocrine pathways. Compared to previous migraine GWAS, our results show minimal vascular tissue enrichment, potentially reflecting the sample composition, which was predominantly men and Veterans. Migraine SNP-based heritability was 10% for men and 16% for women, and several sex-specific loci were identified through sex-stratified analyses. Despite high genetic correlations with neuropsychiatric disorders - including post-traumatic stress disorder, depression, and traumatic brain injury - Mendelian randomization analyses found no causal links. Finally, we prioritized potential migraine drug targets, including losmapimod (which reduces production of toxic DUX4 protein) and TLR4 antagonists. - Source: PubMed
Publication date: 2025/12/19
Gasperi MariannaRosenthal Sara BrinMaihofer Adam XGerstenberger ArmandDochtermann DanielChoquet HélènePressman AlicePanizzon Matthew SStein Murray BSchuster Nathaniel MPyarajan Saiju Afari NiloofarNievergelt Caroline M