Ask about this productRelated genes to: A1CF antibody
- Gene:
- A1CF NIH gene
- Name:
- APOBEC1 complementation factor
- Previous symbol:
- -
- Synonyms:
- ACF, ASP, ACF64, ACF65, APOBEC1CF
- Chromosome:
- 10q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2007-11-23
- Date modifiied:
- 2016-10-05
Related products to: A1CF antibody
Related articles to: A1CF antibody
- Hepatic fibrosis is a reversible wound-healing response to acute or chronic liver injury, and currently lacks effective therapeutic drugs. Continentalic acid (CNT) is the effective ingredient from Aralia continentalis Kitag., used as medicinal and edible homologous plant, and exhibits anti-inflammatory and hepatoprotective effects. - Source: PubMed
Publication date: 2026/07/09
Dai XuGao ChongZheng ShuangJin Na-YanJia Shi-YuLian Li-HuaNan Ji-XingCui Zhen-YuWu Yan-Ling - Soft tissue sarcomas (STSs) are rare, heterogeneous cancers with over 70 subtypes, often diagnosed late due to diagnostic complexity, leading to poor outcomes. We aimed to identify and validate novel transcriptomic biomarkers for the diagnosis and prognosis of STS using an integrative machine learning and bioinformatics framework applied to publicly available cohorts. - Source: PubMed
Publication date: 2026/06/08
Avateffazeli MasoumeRahmati RahemMohammadnia AbdolrezaHajimoradi MaryamNazari ElhamShafaghi Shadi - Teratozoospermia is an abnormal sperm morphology that is a common cause of male infertility. Epigenetic factors have been implicated in the regulation of gene expression in teratozoospermia, but the specific mechanisms are not fully understood. This study aimed to identify differentially expressed genes (DEGs) between teratozoospermia and normozoospermia samples, and to investigate the role of epigenetic regulatory factors in the observed gene expression changes. The study integrated data from three publicly available datasets in the GSE6969 superseries. The DEGs were compared to a list of known human epigenetic-related genes obtained from the EpiFactors database. The protein-protein interaction (PPI) network and hub gene identifications for Epi-DEGs and the RNA-protein interaction (RPI) network to obtained the RBPs interacting with Epi-DEGs were constructed. siRNA design for the candidate mRNA was performed using various bioinformatics tools. As a result, the obtained 1,292 DEGs were compared to a list of 796 known human epigenetic factors, revealing 63 Epi-DEGs. The PPI network of Epi-DEGs identified top 10 hub genes including , , , , , , , , and . The RPI network analysis revealed , and as key RNA-binding protein regulators epigenetic modifiers. Based on these findings, the study designed the sequence GCAACAAGAGAAGAA GCAATT as an optimal siRNA candidate targeting the master regulator IGF2BP2, which exhibited the most significant change in expression among the RNA-binding proteins (RBPs). This integrative analysis sheds light on the epigenetic mechanisms underlying teratozoospermia and highlights the potential of RBPs as diagnostic biomarkers and therapeutic targets for further investigation. - Source: PubMed
Mousavi Seyedeh ZahraMohammad-Soltani BahramHadizadeh MortezaRokhsattalab ZeynabTotonchi Mehdi - Lupus nephritis (LN) is the most common complication of systemic lupus erythematosus. CircRNA MTND5 (circMTND5) contributes to the pathogenesis of LN by sponging miR6812. However, it remains unclear what role RNA binding protein to circMTND5 might play. We investigated whether circMTND5 interacts with RNA binding proteins (RBP) in the progression of LN, and to clarify the mechanisms. - Source: PubMed
Publication date: 2025/08/23
Ma CongLuan JunjunJiao CongcongHao XiangnanFu JingqiKopp Jeffrey BPi JingboZhou Hua - Adenomatous polyposis confers an increased risk of developing colorectal cancer. and are the major genes investigated in patients suspected of having polyposis. In addition to and genes, other genes, such as , and , have recently been associated with polyposis phenotypes, conferring heterogeneity in terms of the clinical, etiological and heritable aspects of patients with polyposis. - Source: PubMed
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