Ask about this productRelated genes to: SNRPB antibody
- Gene:
- SNRPB NIH gene
- Name:
- small nuclear ribonucleoprotein polypeptides B and B1
- Previous symbol:
- SNRPB1
- Synonyms:
- COD, SmB/SmB', Sm-B/B', snRNP-B
- Chromosome:
- 20p13
- Locus Type:
- gene with protein product
- Date approved:
- 1988-11-28
- Date modifiied:
- 2015-09-02
Related products to: SNRPB antibody
Related articles to: SNRPB antibody
- Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with poor prognosis. Small nuclear ribonucleoprotein polypeptide B (SNRPB) has been implicated in the progression of various types of cancer; however, the specific role of this protein in ESCC remains unclear. The present study aimed to investigate the expression and functional significance of SNRPB in ESCC. Bioinformatics analysis was performed to assess SNRPB expression and its clinical relevance in ESCC. Immunohistochemical staining of ESCC tissue samples demonstrated significantly elevated SNRPB expression in tumor tissues, compared with adjacent non-cancerous esophageal tissues. Analysis of public database (TCGA) and institutional clinical data revealed that high SNRPB expression was associated with poor prognosis and advanced clinical stage (T stage), respectively. To evaluate the functional role of SNRPB, a lentivirus-based short hairpin RNA vector was used to inhibit endogenous SNRPB expression in ESCC cell lines. Functional assays, including colony formation, flow cytometry and western blot analysis, demonstrated that SNRPB knockdown significantly inhibited cell proliferation, induced cell cycle arrest and promoted apoptosis. Moreover, molecular analysis indicated that SNRPB knockdown led to modulation of the cell cycle and proteins associated with apoptosis. These findings suggested that SNRPB is a key regulator of ESCC progression, through impacting cell proliferation and apoptosis. Collectively, results of the present study demonstrated that SNRPB may act as a potential prognostic biomarker and therapeutic target for ESCC. - Source: PubMed
Publication date: 2026/03/30
Guo HaiyangZuo JiHu GuangbingTang YongLu LiuyiLuo ZichenChen XinruiWang XiaoboWang Xianfei - The Solute carrier family 25 member 3 (SLC25A3), a mitochondrial solute carrier protein, has been implicated in tumor progression. Nonetheless, the connection between SLC25A3 and hepatocellular carcinoma (HCC) remains ambiguous. - Source: PubMed
Publication date: 2026/01/24
Bie BeibeiLiu LibingWang FurongMeng XianingWu MengdiSun Jin - We present a unique case of an infant born with both a microduplication of 22q11.2 and SNRPB gene mutations suggestive of cerebro-costo-mandibular syndrome (CCMS). Microduplications of 22q11 are known to present with a variety of phenotypes ranging from asymptomatic to significant physical and mental health challenges. CCMS is a rare autosomal dominant condition caused by a mutation in the SNRPB gene and typically presents with posterior rib malformations and branchial arch deformities. There have been less than 100 reported cases of CCMS in the literature, and this may be the first documented case of a patient with both CCMS and a 22q11 microduplication. - Source: PubMed
Publication date: 2026/02/19
Slear ElizabethThompson ClaireRuas Virginia - Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive liver malignancy with limited therapeutic options and poor prognosis. Recent evidence indicates that lactate metabolism (LM) plays a pivotal role in tumor metabolic reprogramming, immune evasion, and disease progression; however, the heterogeneity and regulatory mechanisms of LM activity within ICC remain largely undefined. - Source: PubMed
Wu An-KeLi Jun-YiZhang KaiMeng MartinWang XueLiu YueXie PengRong Wei-QiWu FanWang Hong-GuangMeng XuanWu Jian-Xiong - Most of the studies on alcohol dependence (AD) emphasize its impact on the nervous system and organ functions of the human body, but its molecular mechanism is largely unknown so far. This study determines serum protein changes in alcohol-dependent patients for the identification of biomarkers and the revelation of molecular mechanisms behind alcohol dependence. - Source: PubMed
Publication date: 2026/02/02
Ye XiaoSheng HuiOuyang YifanWu QianAbudula AbuliziReheman Aikebaier