Ask about this productRelated genes to: DAZL antibody
- Gene:
- DAZL NIH gene
- Name:
- deleted in azoospermia like
- Previous symbol:
- DAZLA
- Synonyms:
- DAZH, SPGYLA, MGC26406, DAZL1
- Chromosome:
- 3p24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-04-25
- Date modifiied:
- 2016-10-05
Related products to: DAZL antibody
Related articles to: DAZL antibody
- Epilepsy is associated with impaired reproductive function and testicular pathologies. Intermittent fasting (IF) is a nonpharmacological metabolic intervention with anti-inflammatory and antioxidant effects. This study investigated the protective effects of IF on testicular damage in a genetic absence epilepsy rat model (GAERS), focusing on histomorphology, oxidative stress parameters, and hormonal profiles. Testicular tissues from Wistar control (WC), Wistar + IF (WIF), GAERS control (GC), and GAERS + IF (GIF) groups (total = 20; 5 rats per group) were evaluated using hematoxylin and eosin and Periodic Acid-Schiff staining. Apoptosis and spermatogenic cell integrity were assessed using caspase-3, P-element-induced wimpy testis (PIWI), and Deleted in Azoospermia-Like (DAZL) immunohistochemistry. Johnsen's score, seminiferous tubule diameter, and epithelial thickness were quantified. Oxidative stress markers, including catalase, malondialdehyde, glutathione, myeloperoxidase, and superoxide dismutase, were measured using spectrophotometric methods, and serum testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) levels were determined using ELISA kits. The GC group showed significantly reduced Johnsen scores, tubular diameters, and epithelial thickness, along with disrupted basement membrane integrity and increased caspase-3 immunoreactivity. IF significantly improved histological parameters, restored basement membrane integrity, reduced apoptosis, and increased PIWI and DAZL expression in the GIF group. IF also ameliorated oxidative stress and elevated reproductive hormone levels, indicating positive modulation of the hypothalamic-pituitary-gonadal axis. In conclusion, IF reduces oxidative stress and preserves seminiferous tubules and hormonal function in genetic absence epilepsy, highlighting its potential as a supportive nonpharmacological approach to protect male reproductive health. - Source: PubMed
Publication date: 2026/04/18
Gökçeoğlu Kayalı DamlaMaraş HaticeÇilingir AybükeKeskin Ahmet AnılYardımcı ÇağanAykurt Fatma BeyzaArslan Eda NurKolbaşı-Erkan BircanÖzdemir-Kumral Zarife NigarCilingir-Kaya Ozlem Tugce - Limitations in genome editing of avian species, including chicken, due to the inaccessibility of one-cell zygotes, have led to the manipulation of primordial germ cells (PGCs) as the primary approach for generating genetically engineered birds. Although plasmid-mediated delivery of clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) has been widely used, it has several limitations, including delayed nuclease activation, increased off-target effects, cytotoxicity, and the inability to apply in vivo selection strategies. Collectively, these limitations highlight the need to develop strategies that achieve high on-target activity at the initial editing step. - Source: PubMed
Publication date: 2026/05/04
Han YujinKwon Chan YoungHan Jae Yong - Androgenic alopecia (AGA), commonly known as male pattern baldness (MPB), affects a significant portion of the population, with impacts on self-esteem and quality of life. 5-alpha reductase inhibitors, including finasteride and dutasteride, are widely used treatments that increase hair density by reducing dihydrotestosterone levels. However, their effects on reproductive health remain a concern, particularly in men of reproductive age. This narrative review synthesizes current clinical and experimental evidence on the reproductive effects of 5-alpha reductase inhibitors. Relevant studies were identified through a review of published literature, including randomized controlled trials, observational studies, and mechanistic investigations. Outcomes of interest included sperm parameters, hormonal profiles, sexual function, and potential long-term reproductive effects. Across studies, finasteride and dutasteride were associated with reductions in sperm count (34% with finasteride, 29% with dutasteride), sperm concentration, and motility. Hormonal alterations included, increased testosterone levels, and variable changes in dihydrotestosterone, estradiol, progesterone and androstenedione levels. Findings related to sexual dysfunction were variable, with some demonstrating persistent decreased libido, erectile dysfunction, and reduced penile sensitivity, months to years after discontinuation. Mechanistic studies in rodents revealed significant reductions in the expression of genes critical to spermatogenesis (Dazl, Prm2, Sycp3, Tsga10) and alterations in penile tissue contractility and nitric oxide synthase signaling, providing potential explanations for these reproductive effects. Overall, while 5-alpha reductase inhibitors are effective treatments for AGA, they may adversely affect reproductive parameters in a subset of patients. While current evidence focuses primarily on single drug regimens, the growing use of combination therapies targeting multiple 5-alpha reductase isotypes raises the potential for additive or synergistic reproductive effects. Given the variability in outcomes and limited long-term data, further research is needed to better characterize these risks, particularly in younger populations and with combination therapies. - Source: PubMed
Publication date: 2026/04/30
Quintero TaniaGratz BenPepperney LukeRosenstadt JakeGallicano G Ian - Organoids are three-dimensional structures that develop in cultures of stem cells, and resemble multicellular organs. While performing long-term culture of Taeniopygia guttata (zebra finch) germline tissue, we observed the formation of germline organoids from cultures of both sexes. These macro-scale structures contain multiple cell types and retain Primordial Germ Cells (PGCs) and their descendant germ-cell lineages for two to four months of culture in vitro. We show that the PGC-specific germline-restricted chromosome (GRC) can be detected after three months of culture, and that the organoids exhibit DAZL- and DDX4-positive structures resembling germinal epithelia. Taken together our results open new possibilities for the study of key steps of avian reproductive development. - Source: PubMed
Publication date: 2026/04/20
Brown BiancaNagy ElizabethTakkar Ajuni KGreengold Naomi AGujar Shreyas SAmini AliCollins Mary ARajabi JavadWalls JennaKaminski ChenaiSanchez MichaelMcQuire-Guzman ElleEllington TarajiBracht John R - This study aimed to investigate the differentiation potential of human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) into male germ-like cells using a three-dimensional poly (L-lactic acid)/gelatin nanofiber (PLLA/GNF) scaffold incorporated with naringin (Nar). - Source: PubMed
Azimi ArianEhterami ArianZamani SepehrAghayan Seyede NazaninYekesadat Seyed MeysamSharifianjazi FariborzSohrabi SinaAlizadeh MortezaSalehi Majid