Ask about this productRelated genes to: XPOT antibody
- Gene:
- XPOT NIH gene
- Name:
- exportin for tRNA
- Previous symbol:
- -
- Synonyms:
- XPO3
- Chromosome:
- 12q14.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-09-28
- Date modifiied:
- 2016-10-05
Related products to: XPOT antibody
Related articles to: XPOT antibody
- Butana are native Sudanese cattle that are well adapted to arid environments and valued for their relatively high milk performance and resilience under harsh conditions. Despite their adaptive advantages, Butana cattle face the risk of genetic erosion due to low production performance and the absence of structured breeding programs underscoring the urgent need to conserve their unique genetic potential for climate-resilient livestock development. - Source: PubMed
Publication date: 2025/11/30
Neumann Guilherme BKorkuć PaulaRahmatalla Siham AReißmann MonikaOmer Elhady A MElzaki SalmaBrockmann Gudrun A - Breast cancer (BC) remains a significant threat to women's health, necessitating the identification of new targets to inhibit its progression. Pyroptosis, a form of programmed cell death characterized by cellular swelling, distortion, and increased inflammatory factors, has emerged as a potential mechanism. High expression of exportin-T (XPOT) is linked to poor prognosis in BC patients, but its role in BC progression is not well understood. - Source: PubMed
Publication date: 2025/09/24
Liang MengWang MinZhu Beibei - Domestic animals provide valuable models for exploring the genetic basis of long-term adaptation to diverse environments over relatively short evolutionary timescales. This study investigates genomic signatures of selection in the Comisana sheep breed (COM), known for its resilience in low-input systems and adaptation to the semi-arid Mediterranean climate. We analysed genotypes from 238 COM individuals, integrating them with data from the Sarda (SAR; N = 138) and Valle del Belice (VDB; N = 125) breeds. Using a combination of extended haplotype homozygosity (EHH)-based and population differentiation-based tests, we identified eight candidate genomic regions under selection in Comisana. Notably, a strong and consistent signal on ovine chromosome (OAR) 2, observed across all methods, encompassed the genes NFIB, FREM1, and ZDHHC21, which are involved in lung development, epithelial integrity, immune regulation, and thermoregulation, traits likely contributing to adaptation in harsh environments. On chromosome 3, three synonymous mutations were detected in the SLC6A15, LEMD3, and XPOT genes, all implicated in tissue repair and defence against pathogens, supporting their role in local adaptation. Other selected regions contained genes associated with milk production. A particularly strong signal on chromosome 6, characterised by a hard selective sweep, likely reflects recent artificial selection driven by structured breeding programmes. Overall, our findings suggest that selection in Comisana sheep targets pleiotropic genes involved in both environmental resilience and dairy performance, underscoring the combined influence of natural and artificial selection in shaping the genomic landscape of Mediterranean dairy breeds. - Source: PubMed
Publication date: 2025/11/19
Ben Jemaa SSenczuk GPersichilli CNegro ACarta FRiggio SSardina M TCesarani AMastrangelo S - Breast cancer (BRCA) remains the most common malignancy and the leading cause of cancer-related death among women worldwide. Recent studies have highlighted dysregulated copper homeostasis as a contributor to tumorigenesis, with cuproptosis-a copper-dependent form of regulated cell death-emerging as a potential therapeutic target. In this study, we systematically evaluated the prognostic significance of cuproptosis-related genes (CRGs) in BRCA by integrating multi-omics data from TCGA and GEO cohorts. Through weighted gene co-expression network analysis (WGCNA), we identified four key CRGs (CCDC24, TMEM65, XPOT, and NUDCD1) to construct a prognostic signature. The resulting risk score effectively stratified patients into high- and low-risk groups, with the high-risk group showing significantly worse overall survival, higher TP53 mutation frequency, and features of an immunosuppressive tumor microenvironment (TME). Functional enrichment analyses further implicated these genes in immune evasion and metabolic reprogramming pathways. Single-cell RNA sequencing (scRNAseq) confirmed heterogeneous expression of the signature genes across distinct cell populations, supporting their involvement in both tumor biology and immune modulation. Clinically, this CRG-based model provides a promising tool for individualized risk assessment and treatment planning. High-risk patients may benefit from intensified therapies or immunomodulatory strategies, while low-risk individuals could be considered for treatment de-escalation. In summary, our findings suggest that cuproptosis may play a regulatory role in BRCA progression and offer a novel, clinically actionable framework for prognostic stratification. - Source: PubMed
Publication date: 2025/09/29
Peng RongrongLi YuXu Bo - Breast cancer (BC) is the most common malignant tumor in women. Exportin-T (XPOT) which is a member of the karyopherin -β family has been identified as a prognostic biomarker in various cancers, but its role in BC remains inadequately understood. This study aims to investigate the clinical characterization and molecular mechanism of XPOT in BC. - Source: PubMed
Publication date: 2025/05/21
Hou ZhichaoMa WenxiaRen DongliangShen NingningBi WeilinGuo MeiqinLi XinzhengWang YanhongJia Hongyan