Ask about this productRelated genes to: FHIT antibody
- Gene:
- FHIT NIH gene
- Name:
- fragile histidine triad
- Previous symbol:
- -
- Synonyms:
- FRA3B, AP3Aase
- Chromosome:
- 3p14.2
- Locus Type:
- gene with protein product
- Date approved:
- 1996-10-18
- Date modifiied:
- 2019-04-17
Related products to: FHIT antibody
Related articles to: FHIT antibody
- Avian leukosis virus (ALV) causes immunosuppression and tumors, resulting in considerable economic losses in the poultry industry. However, the genetic basis of ALV susceptibility in indigenous breeds remains elusive. Herein, we conducted a genome-wide association study for ALV susceptibility in 259 Wuhua yellow chickens, an indigenous Chinese breed with known disease resistance. ALV infection status was determined by p27 antigen ELISA at 46 weeks of age, with 10 individuals (3.9%) classified as positive. We identified 58 significant SNPs, all located on chromosome 12 and concentrated within a 1.03-Mb region (12.19-13.22 Mb), using SAIGE to account for extreme case‑control imbalance. Gene annotation demonstrated 11 candidate genes, among which FHIT accounted for 44 of the 58 significant SNPs (76%). Additionally, PDHB, PTPRG, FAM3D, and FAM107A were identified as potential candidate genes associated with ALV susceptibility. Notably, conditional analysis confirmed that the lead SNP in FHIT (chr12:12,650,715) is the main driver of this cluster, given that its inclusion as a covariate eliminated all neighboring signals. Functional enrichment showed the citrate cycle as the most considerably enriched pathway, highlighted by PDHB, alongside pyruvate and carbon metabolism. The convergence of tumor suppression (FHIT, FAM107A), metabolic reprogramming (PDHB), and immune/signaling (PTPRG, FAM3D) genes within a single genomic region suggests a potential resistance-associated haplotype block. Our study provides promising candidate genetic markers for breeding ALV-resistant lines and offers novel insights into host-retrovirus interactions beyond traditional immune signaling. - Source: PubMed
Publication date: 2026/06/10
Huang XunheXie TingtingXu YongjieWeng ZhuoxianZhang LiDu Bingwang - This study aimed to identify genetic markers for body weight in adult male Dongfeng sika deer (Cervus nippon) using a genome-wide association study (GWAS). A cohort of 266 healthy, five-year-old stags was phenotyped and genotyped via whole-genome resequencing. Population structure was assessed, and a mixed linear model (MLM) was employed for association testing, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of candidate genes. The GWAS identified twelve genome-wide significant SNP loci, which were annotated to seven candidate genes: ERC2, LOC122708028, FHIT, CASP14, UBE3A, NRXN3, and GABRA5. Functional enrichment analyses revealed these genes are significantly involved in the γ-aminobutyric acid (GABA)ergic synaptic transmission pathway and pathways related to DNA damage repair and cell cycle regulation. This study provides insights into the genetic mechanisms underlying body weight traits in adult male Dongfeng sika deer and offers a reference for subsequent functional exploration of candidate genes. - Source: PubMed
Publication date: 2026/06/11
Zhang XinyuanZhang YanZhao LiepingZhao YaoQian Wen-XiGai GuanghuiSong JunDu PeizeHan HuanshengZhang Zhen - Metabolic dysfunction-associated steatohepatitis (MASH) is a leading cause of chronic liver disease, yet its pathogenesis remains incompletely understood. Immune dysregulation, particularly intrahepatic T-cell responses, is implicated in disease progression; however, the specific roles of T-cell subsets and their regulatory mechanisms are not fully defined. - Source: PubMed
Publication date: 2026/06/12
Yang YanyingLu JieMa MingyueZhou JingWang ELu YanDai ZheZhou BingLi Yao - Ulcerative colitis (UC) is marked by epithelial barrier damage and immune dysregulation, and current therapies often fail to achieve both effective inflammation control and durable immune restoration. Rexiao Kuining decoction (RXKND), derived from San Huang Xie Xin decoction recorded in Synopsis of Prescriptions of the Golden Chamber, has been used clinically for UC, but its mechanisms remain unclear. - Source: PubMed
Publication date: 2026/06/08
Xiao Si-NanCai TaoXia Jia-YiZhou LingCao Ruo-XiCao Bo - FHIT functions as a tumor suppressor frequently silenced by promoter hypermethylation in multiple cancers, including cervical cancer. This study elucidates its role in progression and immunoregulation of cervical squamous cell carcinoma (CSCC) and identifies downstream molecular mechanisms. - Source: PubMed
Publication date: 2026/05/11
Zheng ShunjieShao FuleiShao LiujuanZhang LinPan QiZhuang ShunhongHu YifeiHu Min