Ask about this productRelated genes to: C16orf73 antibody
- Gene:
- MEIOB NIH gene
- Name:
- meiosis specific with OB-fold
- Previous symbol:
- C16orf73
- Synonyms:
- MGC35212
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2006-06-14
- Date modifiied:
- 2019-01-10
Related products to: C16orf73 antibody
Related articles to: C16orf73 antibody
- Programmed DNA double-strand breaks (DSBs) are a hallmark of meiosis, which have to be precisely repaired through meiotic recombination for ensuring genome stability and ultimately generating haploid gametes. Single-stranded DNA (ssDNA) is a central intermediate during DNA repair, primarily generated by nucleolytic resection of DSB ends and by strand displacement during homology search and strand invasion. In mammalian meiosis, resected 3' ssDNA overhangs are rapidly coated by replication protein A (RPA), which stabilizes ssDNA and prevents secondary structure formation. Subsequently, with the assistance of BRCA2 and other accessory factors, the recombinases RAD51 and DMC1 are loaded onto DSB sites to form nucleoprotein filaments. Furthermore, a meiosis-specific ssDNA-binding complex, the MEIOB/SPATA22 heterodimer, regulates recombination intermediate stability and processing. In addition, ssDNA can hybridize with RNA to form DNA-RNA hybrids, representing another way for ssDNA utilization. In this review, we summarize current knowledge of ssDNA generation, utilization, and turnover during mammalian meiotic recombination and highlight unresolved questions for further investigation. - Source: PubMed
Publication date: 2026/05/14
Cheng RuolinJiang HaoyangQin WeicongZhang LuxiGao YuLu XuanWang XuechunZhang LiminFan CunxianNie HuiWang YingYang XiaoWang ShunxinZhang LiangranZhai Binyuan - Air pollution exposure is increasingly recognized as a risk factor for chronic kidney disease (CKD), but the underlying mechanisms, especially the complex gene-environment interactions as reflected in genetic susceptibility, transcriptomic, and proteomic signatures, remain to be elucidated. - Source: PubMed
Publication date: 2026/05/09
Lu JianSun ShuaigangShang XinruDeng ZekaiWang ShunweiJiang ShiminLi Wenge - Understanding the genetic basis of male reproduction in mammals remains challenging. Commercial pig populations offer a unique model for studying fertility, as semen traits are routinely recorded using high-throughput systems. - Source: PubMed
Publication date: 2025/12/15
Sá PedroGòdia MartaGodinho Rodrigo MSevillano Claudia AHarlizius BarbaraMadsen OleBovenhuis Henk - Cattle-yak, a hybrid of yak and cattle, exhibits significant heterosis but male infertility, hindering heterosis fixation. Although extensive research has been conducted on transcriptional mechanisms in the testes of cattle-yak, the understanding of their translational landscape remains limited. In this study, we characterized the translational landscape of yak and cattle-yak based on Ribo-seq technology integrated with RNA-seq data. The results revealed that gene expression was not fully concordant between transcriptional and translational levels, whereas cattle-yak testes exhibited a stronger correlation across these two regulatory layers. Notably, genes that were differentially expressed at the translational level only (, , and ) were mainly involved in meiosis. A total of 4,236 genes with different translation efficiencies (TEs) were identified, and the TEs of most of the genes gradually decreased as the mRNA expression level increased. Further research revealed that genes with higher TE had a shorter coding sequence (CDS) length, lower GC content, and higher normalized minimum free energy in the testes of yaks, but this characteristic was not found in cattle-yaks. We also identified upstream open reading frames (uORFs) in yak and cattle-yak testes, and the sequence characteristics of translated uORFs and untranslated uORFs were markedly different. In addition, we identified several short polypeptides that may play potential roles in spermatogenesis. In summary, our study uncovers distinct translational dysregulations in cattle-yak testes, particularly affecting meiosis, which provides novel insights into the mechanisms of spermatogenesis and male infertility in hybrids. - Source: PubMed
Publication date: 2025/07/25
Cao MengliGuo ShaokeDing ZiqiangHu LiyanXiong LinGe QianyunPei JieGuo Xian - Translation regulation plays a crucial role in testicular development and spermatogenesis, but its dynamic mechanism has not yet been elucidated. This study integrated transcriptome data through ribosomal sequencing (Ribo-seq) to analyze the translation landscape of yak (Bos grunniens) testes at 6 months (Y6M), 18 months (Y18M), and 4 years (Y4Y) of age. The results revealed that the ribosome footprint characteristics of yaks were consistent with those of other mammals. The differentially translated genes during sexual maturity are significantly enriched in the meiotic cell cycle, PI3K Akt, and Notch signaling pathways. From Y6M to Y18M, most of the TE altered genes showed inverse transcription-translation efficiency trends, potentially involved in protein ubiquitination modification. From 18 M to 4Y, translationally altered genes lacked transcriptional changes but associated with acetyltransferase and phosphotransferase activity. PPI analysis identified stage-specific regulatory genes: COL1A2/MEIOB/SYCP3 (6 M-18 M) and STAT1/ITGB5/ERBB2 (18 M-4Y). Additionally, we identified 106 predicted translatable small open reading frames (sORFs), which included annotations for 58 known coding proteins and 1 long non-coding RNA. Sequence feature analysis revealed that higher translation efficiency correlates with longer uORF length, lower GC content, shorter CDS length, and higher NMEF. In conclusion, the results provide new insights into the dynamic regulation of gene translation during testicular development and spermatogenesis, which is highly significant for enhancing yak reproductive performance. - Source: PubMed
Publication date: 2025/08/04
Guo ShaokeCao MengliWang XingdongDing ZiqiangKang YandongHu LiyanZhang BenPei JieGuo Xian