Ask about this productRelated genes to: LOC342897 antibody
- Gene:
- NCCRP1 NIH gene
- Name:
- non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
- Previous symbol:
- -
- Synonyms:
- LOC342897, NCCRP-1, FBXO50
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2008-10-22
- Date modifiied:
- 2016-05-12
Related products to: LOC342897 antibody
Related articles to: LOC342897 antibody
- The low response rate to immunotherapy in patients with lung adenocarcinoma is primarily due to tumor immune evasion. The tumor immunosuppressive microenvironment orchestrates this evasion, yet the underlying mechanisms remain elusive. Here we identify non-specific cytotoxic cell receptor protein 1 (NCCRP1) as a critical and previously uncharacterized regulator of this process. - Source: PubMed
Publication date: 2026/08/05
Liu LuQi ShihaoShao LiyeCai JunyangZeng QingqingJiang XuMa FangLin Weiwei - This study evaluated the immunomodulatory effects of dietary β-glucan derived from the marine diatom Chaetoceros muelleri on immune responses and survival of Nile tilapia (Oreochromis niloticus) following Tilapia Lake Virus (TiLV) infection. Juvenile tilapias were fed diets supplemented with 0.1% or 0.2% β-glucan for 14 days prior to viral challenge. Fish were subsequently challenged with TiLV and immune-related gene expression was analysed in spleen and liver tissues. Fish fed the 0.1% β-glucan diet showed significantly lower cumulative mortality (26.67%) compared with the control group (55.56%) and the 0.2% group (42.22%). Dietary β-glucan significantly influenced the expression of multiple immune-related genes including cytolytic (NCCRP-1), stress-related gene (Hsp70), antimicrobial protein (C-lysozyme), cytokine (IL-8), pattern recognition receptors (TLR3, TLR5, TLR9), signalling adaptor (myD88), antiviral effector (Mx, RSAD-2), adaptive immunity (IgM, CD4). Correlation heatmap and gene co-expression network analyses revealed coordinated immune regulation, with Mx, RSAD-2 and CD4 acting as central hub genes associated with antiviral defence pathways. These results demonstrate that moderate dietary supplementation with C. muelleri-derived β-glucan enhances immune responses and improves resistance to TiLV infection in Nile tilapia, supporting its potential application as a functional feed additive in tilapia aquaculture. - Source: PubMed
Publication date: 2026/04/13
Madyod SulaimanPholmai SuwannaPrombanchong ThitikornLaksana-Aut PatcharaponUnajak SasimanasHirono IkuoWuthisuthimethavee Suwit - Pancreatic cancer (PC) is a highly fatal malignancy and one of the leading causes of cancer-related deaths globally. Pancreatitis and inflammation-induced epigenetic changes, such as DNA methylation, have been reported to be involved in carcinogenesis and progression of PC. The present study examined the precise expression and DNA methylation status of nonspecific cytotoxic cell receptor protein 1 (NCCRP1), identified as a methylation target gene in esophageal cancers, in paired adjacent normal pancreas and PC tissues. NCCRP1 expression was immunohistochemically analyzed using formalin-fixed, paraffin-embedded sections of 73 patients with PC who underwent surgery. The DNA methylation status was analyzed in 52 paired adjacent normal and PC tissues using pyrosequencing. In normal pancreatic tissues, NCCRP1 expression was restricted to acinar cells and absent in ductal and islet cells. Most PCs (64/73) showed a loss of NCCRP1 expression, whereas NCCRP1 expression was observed in 9 cases. Among the NCCRP1-positive cases, 8 (89%) were classified as anaplastic carcinoma, an undifferentiated subtype of PC. When human PC cell lines were treated with 5-aza-2'-deoxycytidine, a DNA-methyltransferase inhibitor, NCCRP1 transcription was induced. Pyrosequencing analysis revealed that the promoter regions of NCCRP1 were highly DNA methylated in PC tissues compared with paired adjacent normal tissues. Furthermore, PC cases with DNA hypermethylated (>18.88%) NCCRP1 exhibited significantly poorer survival than those with relatively low levels of NCCRP1 methylation (P=0.0164). The data collectively suggested that NCCRP1 expression was frequently lost in PC, likely due to promoter hypermethylation, resulting in poor prognosis. This indicates the potential of NCCRP1 as a diagnostic and prognostic biomarker and a therapeutic target for patients with PC. - Source: PubMed
Publication date: 2026/03/17
Nakamura MaiHagiwara TerukiYamada KazuhikoIgari ToruFukumura YukiSaiura AkioTakemura NobuyukiKokudo NorihiroKawamura Yuki I - The health of aquatic ecosystems is threatened by numerous chemicals, posing a critical global challenge. This study aimed to establish a noninvasive monitoring approach based on water environmental RNA (eRNA). This method assesses aquatic ecological status and provides early warnings of chemical stress risks by capturing transcriptome-wide metabolic activity from organisms in ambient water. Zebrafish were exposed to chemicals (carbendazim, chlorpyrifos, and their mixture) with distinct concentrations and modes of action in aquariums. First, zebrafish-derived transcripts accounted for 1.77-4.81% of total water eRNA transcripts, with 3370 genes annotated, of which 13.94-28.53% could be tracked to specific tissues, predominantly the scale and testis, functionally enriched in metabolic and cellular processes. Furthermore, the water eRNA exhibited perturbation potencies of carbendazim that were ∼2 and ∼8 times higher than organismal RNA (oRNA) derived from the zebrafish whole body at the gene and pathway levels, respectively. Finally, zebrafish eRNA profiles distinguished chemical exposures via adaptive pathway perturbations, alongside the identification of 12 candidate biomarker genes, such as , for future eRNA-based chemical discrimination. Overall, this study deciphered zebrafish transcriptional dynamics in water eRNA under varied chemical exposures, contributing to the methodological advance in ecotoxicology and advancing eRNA-based early warning applications in global water management. - Source: PubMed
Publication date: 2025/10/21
Gou XiaoLiu XianglinSu XinxinJi HuiminWang QiongZhang Xiaowei - Triple-negative breast cancer (TNBC) poses challenges in treatment due to its inherent biological characteristics. Endoplasmic reticulum stress (ERS) has been associated with the development of TNBC. Hence, identifying ERS-related prognostic biomarkers is crucial for the early diagnosis and treatment of TNBC. In this study, we retrieved gene expression profiles from TNBC patients using The Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) between TNBC tumor and normal tissues were identified using limma package. Using differential expression analysis, we identified 46 ERS-related DEGs. Through univariate Cox, LASSO, and multivariate COX regression analyses, we constructed a prognostic model consisting of 8 genes (IGFBP1, CFTR, THBS4, CREBRF, CLU, HDGF, DERL3, NCCRP1). This model demonstrated robust prognostic accuracy in TNBC patients, validated by the METABRIC dataset. Among the 8 prognostic genes, NCCRP1 showed the highest expression increase in BT-20 and MDA-MB-468 cells. Functional assays further revealed that NCCRP1 significantly promoted proliferation, migration, and invasion, while suppressing apoptosis and ERS in these TNBC cell lines. Our study highlights a strong association between ERS-related genes and the prognosis of TNBC patients. Moreover, we demonstrated that NCCRP1 exerts oncogenic effects in TNBC cells. It provides new insights and possible treatment targets for TNBC. - Source: PubMed
Publication date: 2025/09/18
Zhang YongqianWang HongminZhu LinglingChen XiaojingZhao MinLiu Ming