Ask about this productRelated genes to: PRR15 antibody
- Gene:
- PRR15 NIH gene
- Name:
- proline rich 15
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 7p14.3
- Locus Type:
- gene with protein product
- Date approved:
- 2006-08-21
- Date modifiied:
- 2019-03-01
Related products to: PRR15 antibody
Related articles to: PRR15 antibody
- Thyroid cancer (THCA) exhibits substantial heterogeneity in clinical outcomes. The interaction between cuproptosis, a novel copper-dependent form of cell death, and mitochondrial energy metabolism, a key regulator of cellular bioenergetics, may influence tumor behavior, yet its role in THCA is not fully elucidated. We integrated transcriptomic data from The Cancer Genome Atlas Thyroid Cancer (TCGA-THCA, n = 510; 457 with survival information) and Gene Expression Omnibus (GEO) cohorts (n = 101). Genes related to cuproptosis and mitochondrial energy metabolism (CMEMRGs) were systematically identified. Bioinformatic analyses included consensus clustering, immune cell deconvolution (CIBERSORT, ESTIMATE), prognostic model construction (LASSO Cox regression), and pathway enrichment (GSEA). We identified a landscape of 460 CMEMRGs in THCA. Unsupervised consensus clustering based on prognostic CMEMRGs revealed two molecular subtypes (Subtype A, n = 393; Subtype B, n = 117) with distinct survival outcomes (p < 0.001). Subtype B was associated with an immune-enriched microenvironment, characterized by differential infiltration of lymphocytes including CD8 + T cells and naïve B cells, and exhibited lower Tumor Immune Dysfunction and Exclusion (TIDE) scores, suggesting a potentially more favorable response to immunotherapy. A prognostic signature comprising 15 CMEMRGs was refined to a 3-gene model (APOE, PRR15, and C3) using LASSO regression. This simplified signature demonstrated predictive value for 4-, 5-, and 6-year overall survival (area under the curve [AUC] = 0.853, 0.789, and 0.789, respectively). Patients stratified into high-risk groups by this model exhibited elevated stromal and immune scores. The risk score showed a trend toward independent prognostic value in multivariate analysis, though further validation is needed. Gene Set Enrichment Analysis (GSEA) indicated an association with MAPK signaling pathways, and protein-protein interaction analysis suggested a direct link between APOE and C3. This integrative analysis indicates that the cuproptosis-mitochondrial energy metabolism axis could be implicated in THCA heterogeneity. The identified molecular subtypes and the 3-gene prognostic signature could provide supplementary insights for risk stratification and warrant further investigation into personalized therapeutic strategies. - Source: PubMed
Publication date: 2026/06/19
Le HongboWu YangWu NanJing RenZhou XiLi YanxingYi ShijianZhang Huihong - BACKGROUND: Inter-tumor heterogeneity poses significant challenges for precision therapy in thyroid cancer (TC). The conventional organoid models are limited by inefficiency and poor physiological relevance. METHODS: We developed droplet-engineered organoids (DEOs) using microfluidic 3D bioprinting to rapidly generate patient-derived TC models. These DEOs were characterized via histology, whole-exome and RNA sequencing, and utilized for drug sensitivity testing and metastasis modeling. RESULTS: DEOs were generated within 10 days, exhibiting superior uniformity (CV: 2.54%) and a high success rate (76%). They faithfully recapitulated the histopathological architecture, genomic landscape (92% driver gene concordance), and native immune microenvironment (CD3+/CD56+/CD68+/α-SMA+) of parental tumors. Drug screening revealed patient-specific heterogeneity, accurately mirroring clinical responses, including cisplatin sensitivity and anti-PD-1 resistance. We established a novel TC and lung organoids co-culture model, which could be used to study the TC lung metastasis. Crucially, transcriptomics identified stage-specific maturation driven by NF-κB signaling. Pharmacological inhibition of NF-κB synergistically enhanced the efficacy of dasatinib, anti-PD-1, and paclitaxel, with combination index (CI) values of 0.58, 0.45, and 0.80, respectively. CONCLUSIONS: Our microfluidic platform enables rapid, high-fidelity modeling of TC, offering a scalable and physiologically relevant tool for mechanistic studies, drug screening, and personalized therapy prediction, with highly promising translational potential. - Source: PubMed
Publication date: 2026/02/27
Gao HengyuanLin JunqingChen XiaobingSu YingshiHuang YibinZhang YuboZhang JunchangXu NanDai Xiaoyong - Cuproptosis is involved in the proliferation, metastasis, and drug resistance formation development of renal cell carcinoma (RCC) by regulating lipid metabolism and oxidative stress levels in the tumor microenvironment, with Ferredoxin 1 (FDX1) as a core regulator. Proline-rich 15 (PRR15) is a proline-rich protein, that we previously found to inhibit the malignant progression of triple-negative breast cancer through the regulation of the phosphatidylinositol 3-kinase (PI3K) pathway and epithelial-mesenchymal transition (EMT) pathway. However, the role of PRR15 in cuproptosis and its molecular mechanisms remain unknown. This study found confirmed that PRR15 promotes cuproptosis and mitochondrial damage in RCC cells and inhibits tumor proliferation and metastasis, as demonstrated in vivo and in vitro. When RCC develops, PRR15 silencing activates the nuclear factor kappa-B (NF-κB) signaling pathway, which inhibits FDX1 expression, ultimately blocking the cuproptosis process and increasing tumor invasiveness. Conversely, overexpression of PRR15 reverses this phenotype. This study reveals for the first time the regulatory mechanism of the PRR15/NF-κB/FDX1 axis in cuproptosis in RCC, providing a new strategy for the treatment of RCC patients. - Source: PubMed
Publication date: 2026/02/11
Ma JialuLi JianqiaoBo ZhihaoZhang ShiyueFeng YuankangLiu XinyuDong YihanLi JiaxinGuo ShaominPan YuejingJiang HuamaoWang RuiYue DanWang Yong - Cryptorchidism, a common congenital malformation in male newborns due to abnormal testicular descent, is closely linked to male infertility and germ cell tumors. The study suggested that estrogen response contributes to its occurrence. - Source: PubMed
Publication date: 2026/01/15
Miao DashuaiSun YifangYu XiangFeng SuyinZhu LongTong XiaoGe WenliangLi Hua - Advanced maternal age (AMA) increases pregnancy risk. However, uterine-specific mechanisms independent of oocyte and embryo quality remain poorly defined. This study aimed to characterise the decidual microenvironment in women with AMA to identify key pathological changes and regulatory pathways. - Source: PubMed
Xie HongliangLu YuZhang AolinZheng AnqiRao BaofengYang CuiyuLi AnyaoGuo WenboHu LinhuaHuang XiaolingWang Chi ChiuZhang SongyingFan XiaohuiLi Lu