Ask about this productRelated genes to: HSPA1L antibody
- Gene:
- HSPA1L NIH gene
- Name:
- heat shock protein family A (Hsp70) member 1 like
- Previous symbol:
- -
- Synonyms:
- HSP70-HOM, hum70t
- Chromosome:
- 6p21.33
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-12
- Date modifiied:
- 2016-10-05
Related products to: HSPA1L antibody
Related articles to: HSPA1L antibody
- The heat shock protein 70 (Hsp70) family is essential for maintaining protein homeostasis and mediating responses to environmental stresses; however, comprehensive characterizations of this family in the mandarin fish (Siniperca chuatsi) are presently absent. Through comparative genomic analysis, a total of 178 Hsp70 genes were identified across nine vertebrate species (human, mouse, and seven teleost fishes), including 17 unique members within the mandarin fish genome. Phylogenetic and gene structure analyses demonstrated that the mandarin fish Hsp70 family has remained highly conserved throughout teleost evolution, marked by lineage-specific expansions (notably in hspa1, hspa4, hspa8, and hspa12) and selective gene loss (e.g., the absence of hspa2 and hspa6). Specifically, tandem duplication was observed for hspa8.1 and hspa8.2, at the same time, two pairs of syntenic genes (hspa4a/hspa4b and hyou1/hspa8b) were found. Ka/Ks analysis further indicated that this gene family has mainly evolved under purifying selection. Transcriptomic profiling showed that hspa8.1 was constantly expressed across all examined tissues. In addition, under thermal stress and Aeromonas hydrophila infection, Hsp70 genes in mandarin fish exhibited divergent expression patterns: certain members contribute to basal homeostasis (e.g., hspa8.1), whereas others demonstrate specialized responses to heat/cold adaptation (e.g., hspa5) or pathogen infection (e.g., hspa1l). Respectively, these findings together provide a thorough understanding of the composition, evolutionary trajectory, and stress-responsive dynamics of the Hsp70 family, establishing a foundational molecular basis for understanding the environmental adaptation of mandarin fish. - Source: PubMed
Publication date: 2026/04/21
Liu YufeiYao XiaoliGao JinhuaIsmaeel HossamChen XiaowuZhao Jinliang - : This study aimed to assess the effects of postbiotic derived from (Szendi2020) on endothelial responses under LPS-induced inflammatory stress. : In human umbilical vein endothelial cells (HUVECs), inflammation was induced with 200 ng/mL LPS. Cell viability, apoptosis, and mitochondrial integrity were assessed using MTT assay, DiIC, and Sytox Green permeability assays. Intracellular ROS levels, heat shock proteins (HSPB1/Hsp27, HSPA1L/Hsp70), adhesion molecules (ICAM-1, VCAM-1), tight junction protein (Occludin), transcription regulators (NF-κB, TNFα), and proinflammatory cytokines (IL-1β, IL-6, IL-8) were quantified using qPCR and ELISA. : LPS exposure significantly induced apoptosis in HUVECs, as reflected by decreased metabolic activity, decreased mitochondrial membrane potential, and increased cell death ( < 0.05). Concurrent postbiotic administration completely abolished LPS-induced cytotoxicity in all assay platforms, demonstrating a potent cytoprotective effect. Postbiotic treatment significantly reduced LPS-induced ROS accumulation ( < 0.05). LPS significantly increased Hsp27 and Hsp70 mRNA expression. However, combined LPS and postbiotic exposure mitigated Hsp27 and Hsp70 mRNA expression compared with LPS treatment alone ( < 0.001, < 0.005). Postbiotic treatment also decreased the upregulation of adhesion molecules induced by LPS. Although this effect decreased after 24 h ( < 0.001). LPS strongly increased NF-κB, IL-1β and TNFα mRNA levels and was suppressed by postbiotics at early time points but not maintained over 24 h. Importantly, postbiotics significantly reduced IL-6, and IL-8 expression at both the mRNA and protein levels, highlighting the attenuation of endothelial inflammatory features ( < 0.05, < 0.005, < 0.001). : Our results are the first to demonstrate that postbiotics derived from (Szendi2020) exert potent cytoprotective and anti-inflammatory effects in LPS-induced endothelial inflammation. By reducing ROS accumulation, preventing apoptosis, stabilizing mitochondrial and barrier integrity, modulating HSP, NF-κB, and cytokine responses. Postbiotics may be promising therapeutic candidates for alleviating endothelial inflammation and the resulting endothelial dysfunction. - Source: PubMed
Publication date: 2026/01/28
Szendi RóbertSzilágyi EndreSzarvas Mária MagdolnaKovács-Forgács IldikóHomoki Judit RitaPesti-Asbóth GeorginaSzőllősi ErzsébetFazekas Mónika ÉvaCziáky ZoltánLukács JánosStündl LászlóSzilágyi-Tolnai EmeseRemenyik Judit - Although immune-mediated diseases (IMDs) and major depressive disorder (MDD) commonly co-occur, the bidirectional relationship between them remains to be fully elucidated. Using data from the prospective UK Biobank cohort, we evaluated the bidirectional associations by time-varying Cox proportional hazards regression models and assessed shared genetic architecture using genome-wide association study summary statistics. Additionally, we employed collagen-induced arthritis (CIA) and chronic social defeat stress (CSDS) mouse models to investigate the relationship between rheumatoid arthritis (RA) and depression. Over 5,226,841 person-years of follow-up, 23,534 incident MDD cases were identified. The presence of any IMD was associated with higher MDD risk (hazard ratio [HR]: 1.95; 95% CI: 1.89-2.01). Conversely, 59,742 incident cases of IMD were documented. MDD was associated with increased IMD risk (HR: 1.47; 95% CI: 1.40-1.54). We observed significant global genetic correlations between IMDs and MDD (r: 0.11-0.49) and identified 128 pleiotropic genes, including ZKSCAN4, BTN3A2, and HSPA1L. Clinically, RA patients exhibited systemic inflammation and decreased levels of brain-derived neurotrophic factor. In experimental models, CIA mice showed depressive-like behaviors and lesions in brain regions implicated in depression. Moreover, superimposing CSDS on CIA exacerbated depressive-like behavior and pain sensitivity, accelerated the onset and progression of arthritis, and heightened joint inflammation. Collectively, these population, genetic, and experimental findings support a bidirectional association and shared genetic susceptibility between IMDs and MDD, highlighting immune-neurobiological pathways, particularly those involving inflammation and neurotrophin dysregulation, as candidates for mechanistic dissection and therapeutic targets. - Source: PubMed
Publication date: 2026/02/04
Chen XiaohuaLiu HuanLiu YurongZhang CongRen YimengLiu PengchengZhang ShanshanLi CongjiaoShen QianWang SiyueZhang ChenhuiWang QingChen XiangliQu YingHuang MengjieTang JieLiu XinGao WenzhenZhong Rong - Butana are native Sudanese cattle that are well adapted to arid environments and valued for their relatively high milk performance and resilience under harsh conditions. Despite their adaptive advantages, Butana cattle face the risk of genetic erosion due to low production performance and the absence of structured breeding programs underscoring the urgent need to conserve their unique genetic potential for climate-resilient livestock development. - Source: PubMed
Publication date: 2025/11/30
Neumann Guilherme BKorkuć PaulaRahmatalla Siham AReißmann MonikaOmer Elhady A MElzaki SalmaBrockmann Gudrun A - Chronic diabetic wounds (DWs) exhibit persistent inflammation, oxidative stress, and dysregulated macrophage polarization, forming a hostile microenvironment that compromises tissue repair. To address these multifactorial barriers, a multifunctional bioresponsive hydrogel (Nar-Zn@GelMA) is designed. GelMA is photopolymerized as the primary network and further crosslinked with Benzaldehyde-PEG-Benzaldehyde (DF-PEG-DF) via dynamic Schiff base reactions, creating a reversible network, while naringenin (Nar) and zinc ions (Zn⁺) endowed antioxidative and immunoregulatory functionalities. The hydrogel demonstrated robust gelation, structural integrity, and favorable cytocompatibility and tissue integration. In vitro, Nar-Zn@GelMA scavenged intracellular reactive oxygen species (ROS), alleviated oxidative stress, and reprogrammed RAW264.7 macrophages toward an M2 phenotype, underscoring its strong immunoregulatory potential. In streptozotocin-induced diabetic mice, topical hydrogel application promoted wound closure and significantly improved re-epithelialization, collagen remodeling, and neovascularization. Proteomic analysis reveals upregulation of key proteins (Hspa1l, Prdx1, Tlr2) involved in immune modulation, inflammatory resolution, and Toll-like receptor signaling, indicative of a synergistic mechanism for microenvironment reprogramming. Histological and biosafety assessments validated excellent tissue integration and systemic compatibility. Collectively, Nar-Zn@GelMA represents a structurally and therapeutically integrated platform offering a robust strategy for chronic diabetic wound regeneration. - Source: PubMed
Publication date: 2025/11/14
Hu SuYuan TianxiangZhao ChenminHuang WenliDing WeiPeng KangWang GangXie Lifang