Ask about this productRelated genes to: ZGPAT antibody
- Gene:
- ZGPAT NIH gene
- Name:
- zinc finger CCCH-type and G-patch domain containing
- Previous symbol:
- KIAA1847
- Synonyms:
- dJ583P15.3, MGC44880, FLJ14972, ZC3HDC9, ZC3H9, GPATC6, GPATCH6, ZIP
- Chromosome:
- 20q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-21
- Date modifiied:
- 2016-10-05
Related products to: ZGPAT antibody
Related articles to: ZGPAT antibody
- Chronic obstructive pulmonary disease (COPD) and allergic diseases share epithelial barrier dysfunction and immune imbalance, yet the shared genetic basis across the full allergy spectrum remains unclear. - Source: PubMed
Publication date: 2025/12/11
Bu LingguangLi Meng - Schizophrenia (SCZ) and bipolar disorder (BPD) are highly heritable psychiatric disorders with complex genetic and environmental underpinnings. Allele-specific expression (ASE) has emerged as a critical mechanism linking noncoding genetic variants to disease risk through epigenetic and environmental modulation. Here, whole-genome and transcriptome analyses of monozygotic twin pairs discordant for BPD or SCZ are performed, identifying that noncoding genetic variants drive differential ASE patterns of long noncoding RNAs (lncRNAs) in affected individuals compared to their unaffected co-twins. The rs112651172 (C/G) is identified as a functional ASE variant regulating PAXIP1-AS1 expression via allele-specific transcription factor binding: SMC3 binds the C allele, while CEBPB binds the G allele, resulting in G allele-specific upregulation in patients. Eevated PAXIP1-AS1 expression is consistently observed in SCZ and BPD postmortem brain tissues from PsychENCODE or LIBD datasets. In mice, G allele overexpression in the prefrontal cortex induces anxiety- and depression-like behaviors, social deficits, memory impairments, sensorimotor gating abnormalities, and reduced neuronal excitability. Mechanistically, PAXIP1-AS1 upregualtes CNTNAP3 by sequestering the transcriptional repressor ZGPAT. Knockdown of CNTNAP3 reversed the observed phenotypes. These findings establish rs112651172 as a regulatory variant linking noncoding genetic risk to psychiatric phenotypeshrough ASE-driven lncRNA dysregulation, suggesting new therapeutic targets in SCZ and BPD. - Source: PubMed
Publication date: 2025/09/05
Ni ChaoyingChen HeChen QiaqiLiao YangyangWang YunqianYe LinyanWu XiaohuiNi HongyuJiang TingyunLi ShufenYang QiongXue HongWang ZhongjuYi FengZhao Cunyou - Chimeric antigen receptor (CAR) T cells and bispecific T cell engagers have become integral components in the treatment of relapsed/refractory multiple myeloma. We report a 63-year-old male who received ciltacabtagene autoleucel CAR T cells and the GPRC5D × CD3 bispecific talquetamab for early relapse of his multiple myeloma. Nine months after CAR T therapy, he developed a symptomatic leukemic peripheral T cell lymphoma with cutaneous and intestinal involvement. Longitudinal single-cell RNA and T cell receptor sequencing of peripheral blood and bone marrow revealed two hyperexpanded CAR-carrying T cell clones. These expanded clones exhibited an exhausted effector-memory T cell transcriptional signature, and the neoplasm itself was sensitive to dexamethasone treatment. The immunophenotypic and transcriptional alterations of these abnormal T cells resembled those of T-large granular lymphocytic leukemia. Spatial transcriptomes of skin lesions confirmed the aberrant CAR-expressing T cells. Whole-genome sequencing revealed three distinct integration sites, within the introns of ZGPAT, KPNA4 and polycomb-associated noncoding RNAs. Before and after CAR T whole-genome analyses implicated clonal outgrowth of a TET2-mutated precursor propelled by additional subclone-specific loss of heterozygosity and other secondary mechanisms. This case highlights the evolution of a CAR-carrying peripheral T cell lymphoma following CAR T cell and bispecific T cell engager therapy, offering critical insights into the clonal evolution from a predisposed hematopoietic precursor to a mature neoplasm. - Source: PubMed
Publication date: 2025/02/21
Braun TillRade MichaelMerz MaximilianKlepzig HannaGroße FlorianFandrei DavidPham Nhu-NguyenKreuz MarkusKuhn Christina KatharinaKuschel FlorianLöffler DennisMeinel JörnHeger EvaSchweinsberg ViolaPflug NataliPlatzbecker UweHallek MichaelHoltick UdoKöhl UlrikeScheid ChristofReiche KristinHerling MarcoRichardson Tim - Investigating whether DNA methylation (DNA-M) at an earlier age is associated with lung function at a later age and whether this relationship differs by sex could enable prediction of future lung function deficit. A training/testing-based technique was used to screen 402 714 cytosine-phosphate-guanine dinucleotide sites (CpGs) to assess the longitudinal association of blood-based DNA-M at ages 10 and 18 years with lung function at 18 and 26 years, respectively, in the Isle of Wight birth cohort (IOWBC). Multivariable linear mixed models were applied to the CpGs that passed screening. To detect differentially methylated regions (DMRs), DMR enrichment analysis was conducted. Findings were further examined in the Avon Longitudinal Study of Parents and Children (ALSPAC). Biological relevance of the identified CpGs was assessed using gene expression data. DNA-M at eight CpGs (five CpGs with forced expiratory volume in 1 s (FEV) and three CpGs with FEV/forced vital capacity (FVC)) at an earlier age was associated with lung function at a later age regardless of sex, while at 13 CpGs (five CpGs with FVC, three with FEV and five with FEV/FVC), the associations were sex-specific (p <0.05) in IOWBC, with consistent directions of association in ALSPAC (IOWBC-ALSPAC consistent CpGs). cg16582803 () and cg14083603 () were replicated in ALSPAC for main and sex-specific effects, respectively. Among IOWBC-ALSPAC consistent CpGs, DNA-M at cg01376079 () and cg07557690 () was associated with gene expression both longitudinally and cross-sectionally. In total, 57 and 170 DMRs were linked to lung function longitudinally in males and females, respectively. CpGs showing longitudinal associations with lung function have the potential to serve as candidate markers in future studies on lung function deficit prediction. - Source: PubMed
Publication date: 2021/07/05
Sunny Shadia KhanZhang HongmeiRelton Caroline LRing SusanKadalayil LathaMzayek FawazEwart SusanHolloway John WArshad S Hasan - The Zrt-/Irt-like protein (ZIP) family consists of divalent metal transporters, ubiquitous in all kingdoms of life. Since the discovery of the first ZIPs in the 1990s, the ZIP family has been expanding to contain tens of thousands of members playing key roles in uptake and homeostasis of life-essential trace elements, primarily zinc, iron and manganese. Some family members are also responsible for toxic metal (particularly cadmium) absorption and distribution. Their central roles in trace element biology, and implications in many human diseases, including cancers, have elicited interest across multiple disciplines for potential applications in biomedicine, agriculture and environmental protection. In this review and perspective, selected areas under rapid progress in the last several years, including structural biology, evolution, and drug discovery against cancers, are summarised and commented. Future research to address the most prominent issues associated with transport and regulation mechanisms are also discussed. - Source: PubMed
Publication date: 2021/01/11
Hu Jian