Ask about this productRelated genes to: PRPS2 antibody
- Gene:
- PRPS2 NIH gene
- Name:
- phosphoribosyl pyrophosphate synthetase 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- Xp22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2014-11-19
Related products to: PRPS2 antibody
Related articles to: PRPS2 antibody
- Endogenous AICAR (acadesine) demonstrates significant therapeutic potential as a phase III clinical agent for the treatment of adverse cardiovascular reactions to coronary artery bypass grafting and as a phase I/II clinical agent for chronic lymphocytic leukaemia. However, its biosynthetic mechanism remains poorly defined. Our previous study demonstrated that AICAR was significantly enriched in the mutant , which overexpressed the global regulator VeA. We found that phosphoribosyl pyrophosphate synthase 2, viz., PRPS2 (PrsA) is regulated by VeA and involved in AICAR synthesis. Deletion of resulted in a significant 17% (μg/mg) reduction in AICAR production in the strain ( < 0.05), whereas its overexpression led to a statistically significant 1.2-fold increase in AICAR content ( < 0.01). Furthermore, we characterised the transcription factor MtfA, which inhibits the expression of gene and is negatively regulated by VeA. Further validation by yeast one-hybrid assay showed that MtfA directly regulated the gene, while AICAR was significantly increased in the deletion mutant. The above results indicate that the global regulator VeA negatively regulates the transcription factor MtfA, which in turn targets negatively regulating transcriptional levels of PRPS2 to mediate AICAR biosynthesis in . - Source: PubMed
Publication date: 2025/06/19
Chen QirongWang JiankangLiu RongfeiLi HuiHe ZhangjiangKang Jichuan - Hyperactive de novo nucleotide synthesis is a metabolic hallmark of pulmonary metastatic triple-negative breast cancer (TNBC), largely driven by upregulation of phosphoribosyl pyrophosphate synthetase 2 (PRPS2). No specific PRPS2 inhibitors are available for clinical intervention of metastasis. - Source: PubMed
Publication date: 2026/03/12
Xu KejiaBai YutingChen HaojieLiu YiLiu HuiminLiu YimengWan XingLiu YanhuaChen YananShi YiXiang RongZeng BeileiCui YanyanFan YanLi JiaWang Longlong - Vesicular stomatitis virus (VSV) is a zoonotic infectious disease that severely impacts the livestock economy. Infection causes vesicle formation, epithelial cell lysis, and severe interstitial edema, accompanied by inflammatory cell infiltration. It can also infect humans and result in a 3 to 5-day illness characterized by fever, headache, fatigue, and muscle aches. (Phosphoribosyl pyrophosphate synthetase 2) PRPS2, a core rate-limiting enzyme in purine and pyrimidine nucleotide biosynthesis, is a key regulator of nucleotide metabolism. In this study, we found that knockdown of PRPS2 significantly attenuated VSV-GFP infection efficiency and suppressed viral replication. Conversely, overexpression of PRPS2 promoted VSV-GFP replication. Further mechanistic exploration revealed that PRPS2 knockdown enhanced IRF3 phosphorylation and upregulated the transcription of IFN-β, CXCL10, and ISG56. This study demonstrates that PRPS2 likely regulates the host innate immune response by modulating IRF3 phosphorylation, thereby influencing VSV replication. These findings reveal the role of PRPS2 in host antiviral immunity and deepen the theoretical understanding of VSV-host interactions. - Source: PubMed
Publication date: 2025/12/11
Xu NuoLi ShuaichenMeng XiangboLi HongkunZhou SunxinWang HengxinLi AnpingWang XinjingZhang Tong - This study aimed to integrate transcriptomes to reveal the regulatory molecular mechanisms of meat quality in different black goat breeds. A comparison of Guizhou Black Goats (GBG♂, n = 7), Black Nubian Goats (NBG♂, n = 7), and their F1 hybrids (FBG♂, GB♀ × NB♂, n = 7) revealed that the FBG demonstrated notable improvements in meat quality parameters, muscle fiber traits, fatty acid and amino acid compositions, mineral content, intramuscular fat (IMF), and inosine monophosphate (IMP) levels. Moreover, transcriptome analysis identified 119, 77, and 82 differentially expressed genes (DEGs) in the GBG vs NBG, FBG vs GBG, and FBG vs NBG comparisons, respectively. Among these, 111, 74, and 82 DEGs were associated with IMF deposition, and 61, 34, and 32 DEGs were linked to IMP deposition, respectively. Of particular note, the analysis pinpointed key genes related to IMF (PFKM and FZD4) and IMP (AMPD3, ENPP1, ENTPD1, ENTPD8, and PRPS2), laying a solid data groundwork for future research aimed at enhancing the meat quality of black goats. - Source: PubMed
Publication date: 2025/07/07
Long YongZhang NaifengBi YanliangMa TaoPaengkoum PramoteXiao WenZhao YanpinYuan ChaoWang DefengYang YangSu ChaozhiHan Yong - Myc hyperactivation coordinately regulates numerous metabolic processes to drive lymphomagenesis. Here, we elucidate the temporal and functional relationships between the medley of pathways, factors, and mechanisms that cooperate to control redox homeostasis in Myc-overexpressing B cell lymphomas. We find that Myc overexpression rapidly stimulates the oxidative pentose phosphate pathway (oxPPP), nucleotide synthesis, and mitochondrial respiration, which collectively steers cellular equilibrium to a more oxidative state. We identify Myc-dependent hyperactivation of the phosphoribosyl pyrophosphate synthetase (PRPS) enzyme as a primary regulator of redox status in lymphoma cells. Mechanistically, we show that genetic inactivation of the PRPS2 isozyme, but not PRPS1, in Myc-driven lymphoma cells leads to elevated NADPH levels and reductive stress-mediated death. Employing a pharmacological screen, we demonstrate how targeting PRPS1 or PRPS2 elicits opposing sensitivity or resistance, respectively, to chemotherapeutic agents affecting the thioredoxin and glutathione network, thus providing a therapeutic blueprint for treating Myc-driven lymphomas. - Source: PubMed
Publication date: 2025/04/25
MacMillan Austin CKarki BibekYang JuechenGertz Karmela RZumwalde SamanthaPatel Jay GCzyzyk-Krzeska Maria FMeller JarekCunningham John T