Ask about this productRelated genes to: LYSMD2 antibody
- Gene:
- LYSMD2 NIH gene
- Name:
- LysM domain containing 2
- Previous symbol:
- -
- Synonyms:
- MGC35274
- Chromosome:
- 15q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-15
- Date modifiied:
- 2016-01-22
Related products to: LYSMD2 antibody
Related articles to: LYSMD2 antibody
- Eggshell quality is a critical trait in poultry production, as it directly influences economic outcomes. The genetic architecture underlying this trait remains poorly characterized. In this study, we conducted a genome-wide association study (GWAS) on Chinese Wenshang Barred chickens at 43 weeks of age to identify genomic loci and candidate genes associated with eggshell quality. This analysis revealed 87 significant SNPs and 14 candidate genes. Genes including , , , , and were associated with eggshell weight; , , , , and with eggshell thickness; and and with eggshell strength. Notably, three SNPs emerged as the most promising markers for eggshell quality, though their functional roles in laying hens require further investigation. This study advances our understanding of the genetic basis of eggshell quality and holds significant practical implications for improving this trait through targeted breeding strategies. - Source: PubMed
Publication date: 2026/07/11
Wang JieHan HaixiaLiu JieLei QiuxiaLiu WeiSun YanHao DanLi FuweiWang XinxiaCao DingguoZhao XinhuaZhou Yan - Lysosome-related organelles (LROs) are specialized lysosomes with cell type-specific roles in organismal homeostasis. Dysregulation of LROs leads to many human disorders, but the mechanisms underlying their biogenesis are not fully understood. Here, we identify a group of LYSMD proteins as evolutionarily conserved regulators of LROs. In Caenorhabditis elegans, mutations of LMD-2, a LysM domain-containing protein, reduce the levels of the Rab32 GTPase ortholog GLO-1 on intestine-specific LROs, the gut granules, leading to their abnormal enlargement and defective biogenesis. LMD-2 interacts with GLO-3, a subunit of GLO-1 guanine nucleotide exchange factor (GEF), thereby promoting GLO-1 activation. Mammalian homologs of LMD-2, LYSMD1, and LYSMD2 can functionally replace LMD-2 in C. elegans. In mammals, LYSMD1/2 physically interact with the HPS1 subunit of BLOC-3, the GEF of Rab32/38, thus promoting Rab32 activation. Inactivation of both LYSMD1 and LYSMD2 reduces Rab32 activation, causing melanosome enlargement and decreased melanin production in mouse melanoma cells. These findings provide important mechanistic insights into LRO biogenesis and functions. - Source: PubMed
Publication date: 2024/07/30
Li JinglinYin QiuyuanXuan NanGan QiwenLiu ChaolianZhang QianYang MeiYang Chonglin - In dogs with congenital portosystemic shunt (CPSS), recovery after surgical CPSS attenuation is difficult to predict. - Source: PubMed
Publication date: 2018/05/17
Van den Bossche Lindsayvan Steenbeek Frank GWeber Maarten FSpee BartPenning Louis Cvan Sluijs Freek JZomerdijk FlinGroot Koerkamp Marian J ARothuizen JanBurgener Iwan AKummeling Anne