Ask about this productRelated genes to: TTC35 antibody
- Gene:
- EMC2 NIH gene
- Name:
- ER membrane protein complex subunit 2
- Previous symbol:
- KIAA0103, TTC35
- Synonyms:
- -
- Chromosome:
- 8q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-30
- Date modifiied:
- 2016-10-05
Related products to: TTC35 antibody
Related articles to: TTC35 antibody
- We used Delphi methodology to provide guidance on gender equality and equity issues in professional life in intensive care, where information is evolving and no clear standard exists. - Source: PubMed
Publication date: 2026/04/15
Myatra Sheila NainanNasa PrashantChanchalani Gunjan PZimmerman Janice LVenkatesh BalasubramanianMachado Flavia ROstermann MarliesLeeies MurdochCoopersmith Craig MSorce Lauren RWeiss BjörnKuberkar DeepaliAbbenbroek BrettAcharya Subhash PAkech SameulAkinci Seda BAl Duhailib ZainabBerger-Estilita JoanaBranson Richard DDe Waele JanDerde Lennie P GDivatia Mihika JDzierba Amy LElhoufy Ashraf MFiest Kirsten MFillipescu DanielaFox-Robichaud Alison EFreires Fabricio J CFujii TomokoGalarza LauraGopalan Dean PHamzaoui OlfaHidalgo Jorge LJayasinghe Aruna SKanoore Edul Vanina SLubis Andriamuri PMatot IditMehta SangeetaMilic VladimirMonnet XavierMorrow Brenda MNadkarni Vinay MNeedham Dale MOsinaike Babatunde BPatil Vijaya PPérez Cornejo M SusanaPerez-Fernandez JavierRay SumitRobba ChiaraRodriguez-Vega Gloria MRubulotta FrancescaSeifelnasr OsamaTurnbull Alison EUgarte SebastiánVincent Jean-LouisWendon JuliaXie JianfengZabaleta Polo Yulieth MBurns Karen E A - Triple-negative breast cancer (TNBC) is associated with poor prognosis and is mainly treated with chemotherapy-based regimens, often including carboplatin. Resistance to carboplatin is a common clinical issue that is either initially present or develops with treatment. Overcoming this resistance is a significant clinical challenge, which highlights the need for novel therapeutic strategies. We used a pooled short hairpin RNA screening approach with a chemoresistant TNBC patient-derived xenograft (PDX) cell line (PDXC) to identify targets in which knockdown would enhance the efficacy of carboplatin. This screening led to the identification of the ataxia telangiectasia and Rad3-related (ATR) gene as a key therapeutic vulnerability. Inhibiting ATR with BAY1895344 or AZD6738 resensitized carboplatin-resistant PDXCs and PDXs to carboplatin, resulting in an increase in DNA damage and apoptosis. ATR inhibition prevents carboplatin-resistant cells from effectively engaging the S and G2-M checkpoints required for DNA repair, leading to mitotic catastrophe. We further identified that the addition of ATR inhibitors to carboplatin enabled the FOXM1-targeted gene program, leading to premature passage into mitosis. Moreover, targeting PKMYT1, a regulator of cyclin-dependent kinase 1 controlling the G2-M checkpoint, through knockdown or with the novel PKMYT1 inhibitor RP-6306, also enhanced carboplatin efficacy in our TNBC PDXC. Molecular factors associated with the response to the ATR inhibitor/carboplatin combination included low RNA levels of PKMYT1. These results underscore the pivotal roles of ATR and PKMYT1 in mediating resistance to carboplatin in TNBC and support targeting these pathways to overcome carboplatin resistance in this disease. - Source: PubMed
Guay JulietKuasne HellenChabot CatherineBozek KathrynMajedi YasaminBuchanan MargueriteAguilar-Mahecha AdrianaBareke EricUlmer BenjaminKong TimYang KangningLiao MinyanElebute OluwadaraGuo RuiningMonast AnieMorin GenevièveHuang SidongPark MoragBasik Mark - Evidence accumulation models (EAMs) explain and predict human choices and response times in a way that maps more directly to cognitive processes than traditional analyses. For example, EAMs can separate the speed-accuracy trade-off from processing capacity. However, little guidance is available regarding how to use EAMs to instantiate cognitive process theories, which often involve complex mappings of parameters to experimental designs. This tutorial illustrates how to embed such theories using the R package EMC2. We show how the effects of cognitive processes can be estimated by mapping EAM parameters to experimental designs using an augmented linear model language. We demonstrate with two examples. The first instantiates a theory of prospective memory. The second instantiates a theory of how humans integrate advice from automated decision aids into their choices. We then show how to combine these two different theories in a unified framework. We conclude by discussing further directions for theory embedding, including non-linear mappings from stimulus values to EAM parameters and the incorporation of trial-by-trial dynamics. - Source: PubMed
Publication date: 2026/04/01
Strickland LukeBoag Russell JStevenson NiekHeathcote Andrew - Recent studies have increasingly demonstrated that chemoresistance in ovarian cancer primarily stems from resistance to oxidative stress and ferroptosis. Ferroptosis, a non-apoptotic form of cell death dependent on intracellular iron and marked by the buildup of lipid reactive oxygen species (ROS), has shown enhanced effectiveness in triggering cell death in ovarian cancer cells. Thus, this study aimed to explore the potential of gene knockdown associated with ferroptosis as an innovative therapeutic strategy against ovarian cancer. Up-regulated genes were identified using a gene bank, and their expression levels were validated through Western blotting (WB) and quantitative PCR (qPCR). Levels of MDA, Fe, GSH, ROS, SQSTM1, LC3-I and LC3-II in ovarian cancer cells treated with sorafenib and subjected to gene knockout were assessed using specific kits. Expression levels of proteins related to ferroptosis were analyzed by WB. Tumor size, volume, ferroptosis and autophagy in ovarian cancer tumor tissues were also examined. IGF2BP3 was elevated in human ovarian cancer and decreased during ferroptosis induced by sorafenib in human ovarian cancer cells. IGF2BP3 knockdown inhibited ovarian cancer cell function and promoted ferroptosis, in addition to autophagy-mediated EMC2 degradation. IGF2BP3 knockdown increased ovarian cancer sensitivity to sorafenib. This study confirmed that IGF2BP3 knockdown inhibited ovarian cancer cell malignancy, promoted ferroptosis and inhibited autophagy-mediated EMC2 degradation, and verified that IGF2BP3 knockdown increased the sensitivity to sorafenib in ovarian cancer mice. - Source: PubMed
Lu XiaopingNi JinpingQian CunyanShi LeiLi AilingYou WeiweiLiu DongmeiXie Yuan - Identifying genomic regions linked to yield and quality is crucial for sorghum (Sorghum bicolor L.) improvement, but limited studies on its genome and diversity hinder breeding efforts. This study aimed to identify phenotypic variance and common quantitative trait nucleotides (QTNs) associated with genomic regions linked with grain yield and quality traits. The experiment was conducted during the 2020 and 2021 growing seasons across three Ethiopian agroecological zones-wet intermediate (Jimma), dry lowland irrigated (Melkassa), and natural drought-prone lowland (Miesso)-using a diverse panel of 358 Ethiopian sorghum landraces. Grain yield reflected both genetic and environmental effects, while the other traits were mainly under genetic control. A multi-locus genome-wide association study (ML-GWAS) was conducted using 209,572 high-quality single-nucleotide polymorphism markers. A total of 27 stable QTNs were identified across six environments using multiple ML-GWAS models. Five QTNs were associated with grain yield, nine with protein content, seven with 1000-seed weight, and six with amylopectin. Two QTNs, S01_65245223 and S09_50940522, were notable in grain yield, with candidate genes encoding a universal stress protein (Sobic.001G363100) and an E3 ubiquitin ligase (Sobic.009G153100), involved in stress response and protein turnover. For protein content, S01_1332500 and S05_53371984 localized with genes encoding EMC2 (Sobic.001G014800) and HVA22-like storage proteins (Sobic.005G121200 and Sobic.005G121300), key for protein folding and accumulation. Note that 1000-seed weight, QTNs S03_3571908 and S01_73998261 were linked to a phospholipase A1 (Sobic.003G038000) and a peptidyl-prolyl isomerase/E3 ligase (Sobic.001G466700), supporting seed filling and growth regulation. For amylopectin, S04_62662803 and S08_53120256 corresponded to GBSSI/SSIIa (Sobic.004G284400) and APS reductase (Sobic.008G118900), central to starch biosynthesis and redox regulation. Multi-locus GWAS revealed stable QTNs for yield and grain quality in sorghum, validating known and novel loci as targets for breeding resilient, biofortified cultivars. - Source: PubMed
Endalamaw ChalachewMenamo Temesgen MKebede Firezer GWondimu ZelekeTekle Hailekiros TadesseShamuyarira KwameJacoby AngelineLabuschagne Maryke Tine