Ask about this productRelated genes to: RFESD antibody
- Gene:
- RFESD NIH gene
- Name:
- Rieske Fe-S domain containing
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 5q15
- Locus Type:
- gene with protein product
- Date approved:
- 2006-08-24
- Date modifiied:
- 2016-01-28
Related products to: RFESD antibody
Related articles to: RFESD antibody
- Plasticity in teleosts is a fascinating evolutionary strategy enables species to acclimate to environmental changes. However, the molecular mechanisms that underlie gonadal differentiation and reversal remain incompletely understood. The four-finger threadfin (Eleutheronema tetradactylum), a protandrous hermaphrodite belonging to the Polynemidae family, serves as an excellent model for studying genes and molecules involved in gonadal transformation. In this study, we used de novo transcriptome sequencing of the male and female gonads to identify key regulatory genes and pathways involved in sex differentiation. A total of 12,034 DEGs were identified, with 7567 upregulated and 4467 downregulated between testes and ovaries. GO and KEGG enrichment analyses identified steroid hormone biosynthesis as the key pathway in gonadal differentiation. Several novel sex biased genes DEGs were identified, including testis-biased genes nefl, rfesd, and gpatch8, and ovary-biased genes ift57, hoxb5a, naxd, and tgfbr3. furthermore, clusters of testis-specific genes, including dnah7, tspan1, hspa8, dnah3, dnah6, dnah17, myo10, kcnq3, dnaaf11, rtase, dmrt1, smcl1b, slc44a5b, tex11,cyp51 and ovary-biased genes, such as cd9, zp2, ccnp, cldnd, znf622, tc1a, hsd17b7, foxl2, sox3, and sox19a were identified, emphasizing their crucial roles in gonadal differentiation. This in-depth transcriptomic study sheds light on the molecular foundations of reproductive adaptability, offering novel insights for disciplines such as aquaculture, conservation and evolutionary biology. - Source: PubMed
Publication date: 2025/07/21
Mkulo Evodia MosesIddrisu LukmanIbrahim SalifuHuang JianshengWang LinjuanZheng AnnaMwemi Happiness MosesMinxuan JinZhang HuijuanTang BaoguiMa QianAmoah KwakuWang BeiWang Zhongliang - Numerous studies have revealed that gamma delta (γδ) T cell infiltration plays a crucial regulatory role in hepatocellular carcinoma (HCC) development. Nonetheless, a comprehensive analysis of γδ T cell infiltration in prognosis evaluation and therapeutic prediction remains unclear. - Source: PubMed
Publication date: 2022/06/10
Wang JingruiLing SunbinNi JieWan Yafeng - The prenatal period is a critical window for the development of autism spectrum disorder (ASD). The relationship between prenatal nutrients and gestational gene expression in mothers of children later diagnosed with ASD or non-typical development (Non-TD) is poorly understood. Maternal blood collected prospectively during pregnancy provides insights into the effects of nutrition, particularly one-carbon metabolites, on gene pathways and neurodevelopment. Genome-wide transcriptomes were measured with microarrays in 300 maternal blood samples in Markers of Autism Risk in Babies-Learning Early Signs. Sixteen different one-carbon metabolites, including folic acid, betaine, 5'-methyltretrahydrofolate (5-MeTHF), and dimethylglycine (DMG) were measured. Differential expression analysis and weighted gene correlation network analysis (WGCNA) were used to compare gene expression between children later diagnosed as typical development (TD), Non-TD and ASD, and to one-carbon metabolites. Using differential gene expression analysis, six transcripts (TGR-AS1, SQSTM1, HLA-C, and RFESD) were associated with child outcomes (ASD, Non-TD, and TD) with genome-wide significance. Genes nominally differentially expressed between ASD and TD significantly overlapped with seven high confidence ASD genes. WGCNA identified co-expressed gene modules significantly correlated with 5-MeTHF, folic acid, DMG, and betaine. A module enriched in DNA methylation functions showed a suggestive protective association with folic acid/5-MeTHF concentrations and ASD risk. Maternal plasma betaine and DMG concentrations were associated with a block of co-expressed genes enriched for adaptive immune, histone modification, and RNA processing functions. These results suggest that the prenatal maternal blood transcriptome is a sensitive indicator of gestational one-carbon metabolite status and changes relevant to children's later neurodevelopmental outcomes. LAY SUMMARY: Pregnancy is a time when maternal nutrition could interact with genetic risk for autism spectrum disorder. Blood samples collected during pregnancy from mothers who had a prior child with autism were examined for gene expression and nutrient metabolites, then compared to the diagnosis of the child at age three. Expression differences in gene pathways related to the immune system and gene regulation were observed for pregnancies of children with autism and non-typical neurodevelopment and were associated with maternal nutrients. - Source: PubMed
Publication date: 2020/11/07
Zhu YihuiMordaunt Charles EDurbin-Johnson Blythe PCaudill Marie AMalysheva Olga VMiller Joshua WGreen RalphJames S JillMelnyk Stepan BFallin M DanieleHertz-Picciotto IrvaSchmidt Rebecca JLaSalle Janine M