Ask about this productRelated genes to: MGC33407 antibody
- Gene:
- ACTL9 NIH gene
- Name:
- actin like 9
- Previous symbol:
- -
- Synonyms:
- MGC33407
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2009-05-15
- Date modifiied:
- 2015-11-17
Related products to: MGC33407 antibody
Related articles to: MGC33407 antibody
- Investigation of in utero, tissue-specific molecular pathways contributing to prenatal programming of childhood-onset asthma is needed to develop effective, targeted prevention strategies. We aimed to examine the relationship between predicted gene expression in placenta and childhood-onset asthma and to compare relationships between childhood- and adult-onset asthma. Asthma genome-wide association study published summary statistics were obtained from the UK Biobank and published placental gene expression quantitative trait loci were obtained from the Rhode Island Child Health Study. We used S-PrediXcan to evaluate and compare associations between placental predicted gene expression and childhood- and adult-onset asthma and to determine whether signals were placenta-specific. Among 8,038 tested placental predicted expression-asthma associations, we identified 56 (0.7%) genes only significantly associated with childhood-onset asthma, 12 (0.1%) genes only significantly associated with adult-onset asthma, and 18 (0.2%) shared genes. Predicted expression of several genes (ACTL9, AMN, C9orf38, C11orf30, CTSE, EFCAB13, EIF4E1B, FN1, GLS2, IL6, IVL, LZIC, MAN2A2, MEGT1, RACGAP1, SMAD6, SPATA5, TMEM25, VTI1B, WDR19) was not significantly associated with childhood- or adult-onset asthma in any non-placental tissue, suggesting that the associations may be placenta-specific. This study identified alterations in predicted expression of placental genes associated with transcriptional pathways critical to the development of asthma. We identified unique and shared pathways, particularly related to immune regulation, associated with childhood- and adult-onset. This expands our understanding of the fetal origins of asthma, highlights the placenta as an informative tissue in understanding asthma pathogenesis, and identifies target genes to prioritize for future functional studies. - Source: PubMed
Publication date: 2026/05/13
Jasper Elizabeth AMcKennan Christopher GThompson Emma ESchoettler NathanGebretsadik TebebHellwege Jacklyn NEdwards Todd LOber CaroleVelez Edwards Digna RHartert Tina VSnyder Brittney M - This paper will identify the potential genetic causes of multimorbidity associated with autosomal dominant congenital cataract (ADCC). - Source: PubMed
Publication date: 2025/05/20
Berry VanitaPonnekanti Manav BAychoua NancyIonides AlexTsika ChrysanthiQuinlan Roy AMichaelides Michel - This study aimed to identify new genes associated with total fertilization failure (TFF) by intracytoplasmic sperm injection (ICSI). - Source: PubMed
Publication date: 2025/05/23
Huang YilianWang YizeLi LouGong FeiLin GeDai Jing - Non-obstructive azoospermia (NOA) is a severe form of male infertility, affecting 10-20% of azoospermic men. Although some NOA genes have been identified, the genetic causes of spermatogenesis failure in NOA remain unclear. This study aimed to identify and characterize genes and mutations associated with NOA. - Source: PubMed
Publication date: 2025/04/27
Yao WenliangFu JingwenZhang DuanjunChen ShenghuiZhou YuliangJiang XianglongZheng XiaotingZhang MingliangWu Feihua - What is the frequency of , , and variants in male patients showing fertilization failure after ICSI, and how effective is assisted oocyte activation (AOA) for them? - Source: PubMed
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Cardona Barberán ArantxaReddy Guggilla RameshColenbier CoraVan der Velden EmmaRybouchkin AndreiStoop DominicLeybaert LucCoucke PaulSymoens SofieBoel AnnekatrienVanden Meerschaut FraukeHeindryckx Björn