Ask about this productRelated genes to: OXR1 antibody
- Gene:
- OXR1 NIH gene
- Name:
- oxidation resistance 1
- Previous symbol:
- -
- Synonyms:
- TLDC3
- Chromosome:
- 8q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-14
- Date modifiied:
- 2016-10-05
Related products to: OXR1 antibody
Related articles to: OXR1 antibody
- In Parkinson's disease and other synucleinopathies, αSynuclein (αSyn) misfolds and forms Ser-phosphorylated aggregates (pSyn) with the factors controlling this process largely unknown. Here, we used arrayed CRISPR-mediated gene activation and ablation to discover new pSyn modulators. Using quadruple-guide RNAs (qgRNAs) and Cas9, or an inactive Cas9 fused to a synthetic transactivator, we ablated 2304 and activated 2428 human genes related to mitochondria, trafficking, and motility functions in HEK293 cells. After exposure of cells to αSyn fibrils, pSyn signals were recorded by high-throughput fluorescence microscopy and aggregates were identified by image analysis. We found that pSyn was increased by activating the mitochondrial protein OXR1, which decreased ATP levels and altered the mitochondrial membrane potential. Instead, pSyn was reduced by ablation of the endoplasmic reticulum (ER)-associated protein EMC4, which enhanced ER-driven autophagic flux and lysosomal clearance. OXR1 activation preferentially modulated cellular reactions to fibrils derived from multiple system atrophy (MSA) patients, whereas EMC4 ablation broadly reduced pSyn across diverse αSyn polymorphs. These findings were confirmed in human iPSC-derived cortical and dopaminergic neurons, where OXR1 preferentially promoted somatic aggregation and EMC4 reduced both somatic and neuritic aggregates. These results uncover previously unrecognized roles for OXR1 and EMC4 in αSyn aggregation, thereby broadening our mechanistic understanding of synucleinopathies. - Source: PubMed
Publication date: 2026/03/30
Neupane SandeshNikolić LeaMaraio LorenzoGoiran ThomasKarpilovsky NathanSellitto StefanoBouris VangelisYin Jiang-AnMelki RonaldFon Edward AAguzzi AdrianoDe Cecco Elena - Methadone maintenance treatment (MMT) is one of the major pharmacotherapies for opioid use disorder. The underlying mechanisms of addiction and the treatment response are only partially understood. The study's main goal was to identify differential DNA CpG methylation that occurred in response to MMT. - Source: PubMed
Publication date: 2026/03/05
Levran OrnaKim YuliLi JustinSason AnatAdelson MiriamPeles Einat - This study aimed to investigate the effects of the "living high-training low" (LHTL) model, in which mice were housed under hypoxic conditions but trained in normoxia to maintain training quality. We analyzed key proteins involved in cellular metabolism and oxidative stress, including hypoxia-inducible factor 1α (HIF-1α), peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), and oxidation resistance protein 1 (OXR1). Forty male isogenic C57BL/6J mice were divided into nontrained (N) and trained (T) groups living in normoxic (NOR) or hypoxic (HYP) environments. HYP mice were housed 18 h/day for 8 weeks in a normobaric tent supplied with oxygen-depleted air (FiO = 14.5%). Animal handling, including training, was conducted in normoxia (FiO = 19.5%). Training occurred 5 times/week (40 min/session) at ~80% of individual critical velocity. All mice were euthanized to extract the soleus, white gastrocnemius, and hypothalamus for protein analysis. Compared with training alone, LHTL did not lead to significantly greater HIF-1α, PGC-1α, or OXR1 expression across tissues; however, induced behavioral changes-such as reduced spontaneous physical activity and diminished ability to complete training-may indicate that the demands of the LHTL model were not trivial. - Source: PubMed
Scariot Pedro P MPapoti MarceloPolisel Emanuel E COrsi Juan BHill David WManchado-Gobatto Fúlvia BGobatto Claudio A - Edible Grass (EG) is a hybrid vegetable variety valued for its high biomass and protein content, garnering significant interest in recent years for its potential in food, feed, and health product applications. However, in subtropical climates, intense light and high temperatures severely affect the growth and development of Edible Grass (EG), leading to substantial reductions in yield and quality. This study was conducted in the subtropical humid monsoon climate zone of Changsha, Hunan, China, comparing two growth conditions: natural light (CK) and shading treatment (ST). High light-aggravated heat damage under CK significantly reduced EG yield and quality ( < 0.05), with severe cases leading to plant death. and could even lead to plant death in severe cases. Specifically, maximum air and leaf temperatures under CK reached 38.85 °C and 38.14 °C, respectively, well exceeding the plant's optimal growth range. Shading treatment (ST) effectively alleviated this damage, significantly increasing the net photosynthetic rate, stomatal conductance, and intercellular CO concentration, while decreasing leaf temperature and transpiration rate ( < 0.001). The analysis of physiological and biochemical indicators indicates that after ST, the activities of SOD, CAT, and POD in the leaves decreased, while the contents of MDA and HO were significantly lower compared to the CK group ( < 0.001). The transcriptome sequencing results indicate that a total of 8004 DEGs were identified under shading treatment (ST) relative to natural light (CK), with 3197 genes upregulated and 4807 genes downregulated. Significantly enriched Gene Ontology (GO) terms include 'cell membrane', 'extracellular region', and 'protein kinase activity', while significantly enriched KEGG metabolic pathways include 'plant hormone signal transduction', 'photosynthesis-antenna proteins', and 'glutathione metabolism'. Compared to CK, the expression of genes associated with oxidative stress (e.g., , , , ) was significantly downregulated in ST, indicating a relief from light-aggravated heat stress. This transcriptional reprogramming was corroborated by metabolomic data, which showed reduced accumulation of key flavonoid compounds, aligning with the downregulation of their biosynthetic genes as well as genes encoding heat shock proteins (e.g., Hsp40, Hsp70, Hsp90). It indicated that plants switch from a 'ROS stress-high energy defense' mode to a 'low oxidative pressure-resource-saving' mode. Collectively, ST significantly alleviated the physiological damage of forage grasses under heat stress by modulating the processing of endoplasmic reticulum heat stress proteins, plant hormones, and related genes and metabolic pathways, thereby improving photosynthetic efficiency and yield. The findings provide a theoretical basis for optimizing the cultivation management of EG, particularly in subtropical regions, where shade treatment serves as an effective agronomic strategy to significantly enhance the stress resistance and yield of EG. - Source: PubMed
Publication date: 2025/12/25
He ZengyangZhong QinzhuoLi XinyaoChen MiaofenLiu WeiJiang TaoZou Jianfeng - Prostate adenocarcinoma (PRAD) is a common malignancy in the male genitourinary system, with growing evidence linking its progression to mitochondrial function and macrophage polarization. This study identifies prognostic genes associated with these factors in PRAD through integrated transcriptomic data analysis and Mendelian randomization (MR). - Source: PubMed
Publication date: 2025/12/31
Heng LiBian HaoZhao ChengjunWei ZhenCao JianchengWang Guanfeng