Ask about this productRelated genes to: MAP7D1 antibody
- Gene:
- MAP7D1 NIH gene
- Name:
- MAP7 domain containing 1
- Previous symbol:
- PARCC1, RPRC1
- Synonyms:
- FLJ10350, FLJ39022
- Chromosome:
- 1p34.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-06-03
- Date modifiied:
- 2014-11-18
Related products to: MAP7D1 antibody
Related articles to: MAP7D1 antibody
- Radiation therapy is a common treatment for patients with esophageal cancer (EC). Local recurrence after radiotherapy is one of the main reasons for treatment failure. Exosomal microRNA (miRNA) is associated with the initiation and progression of EC. However, the efficacy of exosomal miRNA in sensitivity to radiotherapy in EC remains unknown. - Source: PubMed
Publication date: 2026/05/12
Ni QingtaoShao ShanshanLu RunsenPan Chi - - Source: PubMed
Publication date: 2026/05/06
Pan ChiNi Qingtao - The importance of microtubule stability and microtubule-associated proteins in the etiology of Shwachman-Diamond syndrome (SDS) has been highlighted in recent studies. In one patient with SDS, a novel MAP7D1:c.601C>T, p.R201W variant has been identified. In this study, the causality of this variant in the pathogenesis of SDS was investigated. Mutation in the microtubule-binding domain of MAP7D1 caused disruption of its interaction with microtubules. SDS fibroblasts exhibited a decreased cell size with reduced microtubule density, and mitotic defects, including multipolar or bipolar unstable spindles, lagging chromosomes, and shortened inter-centrosomal distance. Additionally, ribosomal protein S14 (RPS14) accumulated within incorrectly dividing SDS fibroblasts. To further evaluate whether these abnormalities are directly attributable to the MAP7D1 mutation, mitotic processes were investigated through genetic manipulations of MAP7D1 in T98G glioblastoma and HEK293T embryonic kidney cell lines. Consistent with data from SDS fibroblasts, similar phenotypes were detected upon overexpression of mutant MAP7D1 and depletion of MAP7D1. Our findings revealed that the MAP7D1 mutation acts as a loss-of-function mutation and contributes to SDS pathogenesis by disrupting microtubule dynamics and ribosomal protein regulation, identifying MAP7D1 as a gene with substantial impact for SDS. - Source: PubMed
Publication date: 2025/08/26
Kucukvardar SerenKarabay Arzu - Myopia (nearsightedness) is a condition in which a refractive error (RE) affects vision. Although common variants explain part of the genetic predisposition (18%), most of the estimated 70% heritability is missing. Here, we investigate the contribution of rare genetic variation because this might explain more of the missing heritability in the more severe forms of myopia. In particular, high myopia can lead to blindness and has a tremendous impact on a patient and at the societal level. The exact molecular mechanisms behind this condition are not yet completely unraveled, but whole genome sequencing (WGS) studies have the potential to identify novel (rare) disease genes, explaining the high heritability. - Source: PubMed
Publication date: 2023/04/06
Haarman Annechien E GKlaver Caroline C WTedja Milly SRoosing SusanneAstuti GaluhGilissen ChristianHoefsloot Lies Hvan Tienhoven MarianneBrands TomMagielsen Frank JEussen Bert H J F M Mde Klein AnneliesBrosens ErwinVerhoeven Virginie J M - Plastics can break down into millions of microplastic (MPs, < 5 mm) particles in the soil and ocean. These MPs can then affect the function of the reproductive system. There is currently no effective solution to this problem aside from traditional Chinese medicine. We have previously used Yishen Tongluo formula (YSTL) to treat sperm DNA damage caused by some toxic substances. - Source: PubMed
Zhang ChenmingWang ZulongMa SichengChen RubingWang ShiqiZhang HaoHua ZhongSun Zixue