Ask about this productRelated genes to: PSMC4 antibody
- Gene:
- PSMC4 NIH gene
- Name:
- proteasome 26S subunit, ATPase 4
- Previous symbol:
- MIP224
- Synonyms:
- TBP7, S6, MGC8570, MGC13687, MGC23214, TBP-7
- Chromosome:
- 19q13.11-q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1995-12-06
- Date modifiied:
- 2015-08-12
Related products to: PSMC4 antibody
Related articles to: PSMC4 antibody
- Patient-derived cell models of dystrophic myogenesis and differentiation are valuable preclinical tools for early and mutation-based assessment of candidate therapeutic approaches. Quantitative measurement of gene expression within such models plays a key role in these studies, but normalisation of RT-qPCR data requires a panel of validated stably expressed reference genes. This study aims to identify stable reference genes for RT-qPCR assays in three human derived muscle immortalized cell lines: one healthy WT (from a 16-year-old donor), and two dystrophic lines, DMD1 (from a 11-year-old patient carrying a stop codon mutation on exon 59) and DMD2, from a 14-year-old patient carrying an exon 48-50 deletion. We screened a pool of 14 candidate genes (ACTB, HPRT1, RPL13A, RPS18, GAPDH, ALAS1, UBC, YWHAZ, IPO8, PSMC4, HSP90AB1, NONO, CSNK2A2, AP3D1), investigating stability of expression from proliferation through to 11 days of myogenic differentiation. Data were analysed using four complementary approaches (Bestkeeper, geNorm, Normfinder and DeltaCt) to determine the most appropriate references both within and between cell lines. Our study shows that RPS18, UBC, YWHAZ scored highly across all comparisons, and we therefore suggest that these three genes represent an appropriate reference panel for these human myogenic cell lines, regardless of genotype or differentiation stage. - Source: PubMed
Publication date: 2026/03/13
Quarta RaffaellaBoccanegra BrigidaCristiano EnricaLadisa AlbertoConte ElenaOhana JessicaMouly VincentDe Luca AnnamariaHildyard JohnCappellari Ornella - The mechanisms underlying carfilzomib (CFZ)-induced cardiotoxicity remain incompletely elucidated. In this study, we used human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to characterize the transcriptional impact of CFZ and to evaluate whether atorvastatin could prevent these deleterious transcriptional changes. hiPSC-CMs were treated with 1 µM CFZ, CFZ + atorvastatin, atorvastatin, or vehicle control, followed by RNA sequencing, differential expression analyses, and pathway analyses. Transcriptomic profiling revealed a marked upregulation of genes in multiple proteasome subunits, including ATPase components (, , , ) and non-ATPase regulatory subunits (, , ), suggesting a strong compensatory activation of proteostasis and protein quality-control pathways in response to CFZ exposure. In addition, several of the most significantly altered genes were those implicated in cardiomyopathy and heart failure, such as and , and many heat-shock proteins, indicating the activation of cardiac stress-response pathways relevant to CFZ-associated cardiotoxicity. Atorvastatin co-treatment partially reversed a subset of CFZ-induced transcriptional changes, particularly within cholesterol biosynthesis and lipid-regulatory pathways (e.g., and ) but did not restore the CFZ-mediated downregulation of sarcomeric genes. Together, these findings define a multifactorial signature of deleterious CFZ-induced transcriptional changes and suggest that atorvastatin may provide partial metabolic, but not structural, cardio protection. - Source: PubMed
Publication date: 2026/01/29
Tantawy MarwaWang DanxinGbadamosi MohammedYu FahongZhang YanpingAlomar Mohammed EShain Kenneth HBaz Rachid CBruno Katelyn AGong Yan - Low-grade gliomas (LGG) are aggressive brain tumors with high rates of recurrence and poor prognosis. PSMC4, a proteasome subunit, plays a role in various cancers, but its function in LGG remains poorly understood. This study explores PSMC4's impact on LGG progression. - Source: PubMed
Publication date: 2026/02/03
Ming WangYunhui SiDongjuan CuiYanhong ZhaoHuijie BieHui ZhaoLiquan QianZhongliang DuLiping Wang - Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne viral disease associated with high mortality. This study aimed to characterize serum proteomic signatures linked to adverse outcomes and to identify prognostic biomarkers with potential translational value for patient management. - Source: PubMed
Publication date: 2025/11/05
Zhao ChenxiGe ZiruoWang RanranXu YanliZhang TingyuJiang ZhoulingLiu LuLin LingChen Zhihai - Non-small cell lung cancer (NSCLC) remains a principal cause of cancer-related mortality. The discovery of novel biomarkers is pivotal for enhancing early diagnosis, refining prognostic evaluations, and optimizing targeted therapeutic strategies. Proteasome 26S subunit ATPase 4 (PSMC4), a proteasome subunit essential for protein degradation, influences tumor progression regulatory mechanisms. Despite its recognized importance, the specific contributions of PSMC4 to NSCLC progression are not well defined. - Source: PubMed
Publication date: 2025/05/02
Zhu LiliLi YuanjunXu YunfeiLei Jian