Ask about this productRelated genes to: MFAP1 antibody
- Gene:
- MFAP1 NIH gene
- Name:
- microfibril associated protein 1
- Previous symbol:
- -
- Synonyms:
- AMP
- Chromosome:
- 15q15.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-06-17
- Date modifiied:
- 2017-05-16
Related products to: MFAP1 antibody
Related articles to: MFAP1 antibody
- Observational studies have suggested that obesity may protect against lung cancer, particularly lung squamous cell carcinoma (LUSC). However, these findings are likely influenced by confounding factors such as smoking. We aimed to clarify the genetic relationship between body mass index (BMI) and LUSC and to identify potential shared therapeutic targets. - Source: PubMed
Publication date: 2026/03/12
Xu KaiLiu TaoLi ZhenWang ManhuaYang ZixuanChen XinyuWang YuqingChen YizhouLin YiyunWang YuZhong GangZhai Xiaoqian - Metamorphosis, the crucial transition from planktonic to sessile life stages, marks a key developmental milestone in marine bivalves, particularly for commercially valuable species like Lutraria sieboldii. We conducted a comprehensive transcriptomic analysis using RNA sequencing (RNA-seq) during the larval settlement stage to elucidate the molecular mechanisms underlying this ecologically and economically significant process. Our study generated 89.64 Gb of high-quality clean data (≥6.20 Gb per sample, Q30 ≥ 92.7 %), ensuring robust and reliable insights into gene expression dynamics. Through weighted gene co-expression network analysis (WGCNA), we identified the turquoise module as a key regulatory network strongly associated with settlement-related traits. This module was significantly enriched in critical biological processes, including mRNA splicing via spliceosome, pathways related to cytoskeletal organization and calcium signaling, and C-type lectin receptor signaling, which are crucial for substrate interaction and tissue remodeling. Notably, hub genes within this module included essential components of the spliceosome (SF3B1, RBM8A), calcium signaling regulators (CALM3), and cytoskeletal modulators (ACTB, MFAP1). Furthermore, transcriptional profiling revealed a significant upregulation of genes involved in inorganic ion transport and metabolism, cytoskeletal dynamics, protein turnover, and energy production. These results offer strong evidence for the coordinated regulation of molecular mechanisms during substrate recognition and tissue restructuring in L. sieboldii metamorphosis. As the first comprehensive transcriptomic resource describing larval settlement in this species, our study advances our understanding of conserved developmental pathways and suggests potential aquaculture strategies, such as optimizing calcium signaling or spliceosome activity to enhance larval settlement efficiency in hatchery settings. - Source: PubMed
Publication date: 2025/06/19
Xu TaiyueZhao ZhenZou JieWu ZhuochengXing JiaminYu CongyanBao LeiWu XiaokeLiu XinLi ChongZhang YongqiangPeng HuijingPan YingZhu Peng - Resistance to androgen receptor (AR)-targeted therapies represents a major challenge in prostate cancer. A key mechanism of treatment resistance in patients who progress to castration-resistant prostate cancer (CRPC) is the generation of alternatively spliced AR variants (AR-V). Unlike full-length AR isoforms, AR-Vs are constitutively active and refractory to current receptor-targeting agents and hence drive tumor progression. Identifying regulators of AR-V synthesis may therefore provide new therapeutic opportunities in combination with conventional AR-targeting agents. Our understanding of AR transcript splicing, and the factors that control the synthesis of AR-Vs, remains limited. Although candidate-based approaches have identified a small number of AR-V splicing regulators, an unbiased analysis of splicing factors important for AR-V generation is required to fill an important knowledge gap and furnish the field with novel and tractable targets for prostate cancer treatment. To that end, we conducted a bespoke CRISPR screen to profile splicing factor requirements for AR-V synthesis. MFAP1 and CWC22 were shown to be required for the generation of AR-V mRNA transcripts, and their depletion resulted in reduced AR-V protein abundance and cell proliferation in several CRPC models. Global transcriptomic analysis of MFAP1-depleted cells revealed both AR-dependent and -independent transcriptional impacts, including genes associated with DNA damage response. As such, MFAP1 downregulation sensitized prostate cancer cells to ionizing radiation, suggesting that therapeutically targeting AR-V splicing could provide novel cellular vulnerabilities which can be exploited in CRPC. Implications: We have utilized a CRISPR screening approach to identify key regulators of pathogenic AR splicing in prostate cancer. - Source: PubMed
Walker LauraDuncan RuaridhAdamson BethKendall HannahBrittain NicholasLuzzi SaraJones DominicChaytor LewisPeel SamanthaCrafter ClaireO'Neill Daniel JGaughan Luke - Colon cancer is associated with multiple levels of molecular heterogeneity. RNA processing converts primary transcriptional RNA to mature RNA, which drives tumourigenesis and its maintenance. The characterisation of RNA processing genes in colon cancer urgently needs to be elucidated. - Source: PubMed
Publication date: 2024/08/18
Hu JianwenNing YingzeMa YongchenSun LieChen Guowei - The extracellular matrix (ECM) is a complex three-dimensional network of macromolecules that provides structural support for the cells and plays a significant role in tissue homeostasis and repair. Growing evidence indicates that dysregulation of ECM remodeling contributes to various pathological conditions in the body, including age-associated diseases. In this work, gene expression data of normal human tissues obtained from the Genotype-Tissue Expression project, as well as data from MatrisomeDB 2.0, the ECM-protein knowledge database, are used to estimate the age-dependent matrisome transcriptome dynamics in the blood, heart, brain, liver, kidneys, lungs, and muscle. Differential gene expression (DE) analysis revealed dozens of matrisome genes encoding both structural elements of the ECM and ECM-associated proteins, which had a tissue-specific expression profile with age. Among common DE genes that changed expression with age in at least three tissues, , , , , , , , , , , , , , and were observed. The findings of the study also reveal that there are sex-specific alterations during aging in the matrisome gene expression. Taken together, the results obtained in this work may help in understanding the role of the ECM in tissue aging and might prove valuable for the future development of the field of ECM research in general. - Source: PubMed
Publication date: 2024/05/07
Guvatova Zulfiya GKobelyatskaya Anastasiya AKudasheva Eveline RPudova Elena ABulavkina Elizaveta VChurov Alexey VTkacheva Olga NMoskalev Alexey A