Ask about this productRelated genes to: OAZ2 antibody
- Gene:
- OAZ2 NIH gene
- Name:
- ornithine decarboxylase antizyme 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 15q22.31
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-22
- Date modifiied:
- 2006-05-11
Related products to: OAZ2 antibody
Related articles to: OAZ2 antibody
- Colorectal cancer (CRC) is a prevalent and increasingly common malignancy that poses significant threats to patient survival and quality of life. This study investigates the role of ubiquitously expressed prefoldin-like chaperone (UXT) in regulating polyamine metabolism, particularly putrescine, and its impact on CRC progression. Through comprehensive bioinformatics analysis, UXT was identified as a key factor positively correlated with putrescine abundance in CRC cell lines. Clinical samples confirmed upregulation of UXT and its positive correlation with putrescine levels. Functional assays revealed that UXT knockdown reduced cell viability, migration, and invasion, while overexpression enhanced these phenotypes. Additionally, UXT knockdown decreased putrescine levels and increased the expression of ornithine decarboxylase antizymes (OAZ1, OAZ2, OAZ3), which negatively regulate polyamine synthesis. Conversely, UXT overexpression exhibited the opposite effects. In vivo experiments using a subcutaneous xenograft tumor model in nude mice showed that UXT overexpression enhanced tumor growth and putrescine levels, and UXT overexpression is associated with an increase in M2 macrophage markers, along with reduced M1-associated markers, while UXT knockdown inhibited these effects. These findings suggest that UXT contributes to CRC progression by regulating polyamine metabolism and macrophage polarization, demonstrating its potential as a therapeutic target to disrupt metabolic pathways essential for cancer cell survival and proliferation. - Source: PubMed
Publication date: 2026/04/03
Chen MingHuang ShisiGong LuWu XingchengLi YingWu Hanbing - Runs of homozygosity (ROH) are continuous stretches of homozygous loci generated from identical haplotypes inherited from a common ancestor. ROH hotspots could be an indicator of footprints from artificial and/or natural selection processes. Here, genomic information of 937 individuals from commercial Saanen herds selected in Brazilian tropical environments was used to characterize the population genetic diversity through a genome-wide assessment of autozygosity and effective population size (Ne), in addition to investigate ROH hotspots for pinpointing genomic regions subjected to selective pressures in Saanen in the tropics. Inbreeding levels are relatively under control in this population, but the Ne estimate above but close to 50 animals would be considered critical for this population to be long-term viable in terms of genetic diversity, demanding extra attention on Ne monitoring by the breeders. Nine ROH hotspots were identified on chromosomes 7, 10, 11, 12, 13, 14, 18, and 24, harboring genes directly related to production and adaptive traits. This includes genes associated with milk and protein yield and somatic cell count (CSNK1G1, PCLAF, TRIP4, ZNF609, OAZ2, PIF1, PLEKHO2, and PTGDR); reproduction (ZNF609, OAZ2, PTGDR, GJA3, GJB2, and GJB6); adaptation to heat stress (HSPA9, SIL1, CTNNA1, RNF17, ZMYM2, PARP4, and XPO4); immune system response to mastitis and other infections (HCK, BPIFA1, and BPIFB1), among others. The various loci directly related to the genetic control of productive and adaptive traits in goats identified in this study suggest possible footprints from artificial and/or natural selection processes related to adaptability of Saanen to tropical production systems. - Source: PubMed
Publication date: 2025/11/03
Fernandes Júnior Gerardo Alvesda Silva Marcos Vinicius Gualberto BarbosaLobo Ana Maria Bezerra OliveiraPanetto João Cláudio do Carmode Moraes Silva KleibePaiva Samuel RezendeFacó Olivardo - Despite few studies focusing on the OAZ2 gene in colorectal cancer, its potential role in colon adenocarcinoma (COAD) prognosis and immune modulation remains underexplored. This study examines the expression and mechanistic involvement of OAZ2 in COAD using data from The Cancer Genome Atlas (TCGA) and additional laboratory experiments. We employed uni- and multivariate Cox hazard regression analyses to evaluate its prognostic significance and gene set enrichment analysis (GSEA) to identify related signaling pathways. Our findings demonstrate significantly lower OAZ2 expression in COAD tissues compared to normal counterparts (P < 0.05) and establish its value as an independent prognostic indicator (P < 0.05). Laboratory experiments further revealed that the protein and mRNA levels of OAZ2 are significantly diminished in COAD compared to adjacent normal tissues, while its antagonist AZIN2 shows elevated expression, suggesting a competitive interaction that may regulate tumor behavior. Overexpression of OAZ2 in RKO colorectal cancer cells significantly reduced their proliferation rate and impaired migration, confirming the functional impact of OAZ2 dysregulation in COAD. Gene Set Enrichment Analysis (GSEA) highlighted the involvement of OAZ2 in cardiac muscle contraction and oxidative phosphorylation pathways. Additionally, OAZ2's association with immune features such as tumor mutational burden (TMB), microsatellite instability (MSI), and immune infiltration underscores its integral role in the tumor microenvironment. These comprehensive findings position OAZ2 as a promising biomarker for COAD prognosis and a potential target for therapeutic intervention, with evidence supporting its regulatory effects on cell dynamics and tumor aggressiveness. - Source: PubMed
Publication date: 2025/03/03
Liu YihengZhang ShengjieLiao WenjieQian JunLu CuihuaJin Li - Focal segmental glomerulosclerosis (FSGS) represents a major global health challenge, with its incidence rising in parallel with advances in diagnostic techniques and the growing prevalence of chronic diseases. This study seeks to enhance the diagnostic accuracy of FSGS by integrating machine learning approaches to identify activated pathways, complemented by robust clinical validation. - Source: PubMed
Publication date: 2025/02/26
Ge YatingLiu XueqiShu JinlianJiang XiaoWu Yonggui - The Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is a very prevalent viral pathogen that can induce reproductive failure in infected sows. PRRSV infection can result in smaller litters, foetal death, late-term abortions and retarded growth of infected piglets. Not all sows respond equally to the infection partly due to genetic factors. In this study, we aimed to characterise the genetic variability of pig resilience to PRRSV infection by using a stability reproductive performance (SRP) index as a proxy of resilience. By comparing reproductive data from 183 sows, we selected 48 sows with extreme SRP values, measured as the difference in piglets lost at farrowings before and during a PRRSV outbreak. Short-read DNA fragments were sequenced from selected sows using an Illumina platform. The analysis of whole-genome sequencing information identified 16 genome regions associated with the SRP classification (cut-off P-value < 10). Functional evaluation of the positional candidates by gene-ontology identifiers and their participation in biological pathways were used to identify genes involved in virus entry and replication (vimentin, RAC1 and OAZ2) but also in immune responses from the host (IRF1, and IL4, IL5 and IL13). Importantly, genes related to chemokines, extracellular proteins and cell-to-cell junction integrity might contribute to placental microseparations, facilitating the trafficking of viral particles from sow to foetus that takes place during the pathogenesis of transplacental PRRSV infection. However, given the small number of animals in the study, these results shall need to be validated in larger populations. - Source: PubMed
Publication date: 2024/08/06
Laplana MRos-Freixedes REstany JFraile L JPena R N