Ask about this productRelated genes to: KIAA1191 antibody
- Gene:
- KIAA1191 NIH gene
- Name:
- KIAA1191
- Previous symbol:
- -
- Synonyms:
- FLJ21022, p33MONOX, p60MONOX
- Chromosome:
- 5q35.2
- Locus Type:
- gene with protein product
- Date approved:
- 2006-01-31
- Date modifiied:
- 2017-06-23
Related products to: KIAA1191 antibody
Related articles to: KIAA1191 antibody
- Emerging infectious diseases are one of the foremost contemporary threats to biodiversity conservation. Outbreaks of novel pathogens can lead to the extinction of host populations, loss of gene flow due to extirpation, and bottlenecks in host populations with surviving individuals. In outbreaks with survivors, pathogens can exert strong selection on hosts, in some cases leading to the evolution of resistance or tolerance in the host population. The pathogen causing sylvatic plague, , was introduced to North America in the early 1900s and caused widespread population declines in prairie dogs (genus ), which experience >95% mortality during epizootics. Recently, survival from plague was documented in a small number of black-tailed prairie dogs () in natural populations in Colorado (United States). We performed whole-genome sequencing on all seven individuals that survived infection with plague and seven individuals that likely died. Using genome-wide association tests, outlier tests, and other inferences of selection, we detected single nucleotide polymorphisms (SNPs) on five scaffolds that were strongly associated with survivorship from plague in nature. One candidate gene, inducible T-cell stimulator (), was also associated with survival in humans during the Black Death in London (United Kingdom), suggesting conservation of gene function across taxonomically diverse lineages. In addition, three candidate genes (, , and ) are different from but in the same gene classes (transmembrane proteins, protocadherins, and Kasuza protein-binding genes) as candidate genes for plague resistance in great gerbils, providing support for the hypothesis that parallel evolution may occur at the level of gene classes in addition to individual genes. Understanding the genomic basis of immunity can enable genetically informed management actions, such as targeted relocation to protect grassland species. Moreover, understanding how rapid adaptation to pathogens occurs can help us predict the time frame and spatial scale at which adaptation may occur, during which other interventions are needed. - Source: PubMed
Publication date: 2025/07/08
Cassin-Sackett LorenTsuchiya Mirian T NDikow Rebecca B - The objective of this study was to identify a novel gene and its potential mechanisms associated with susceptibility to gestational diabetes mellitus (GDM) through an integrative approach. - Source: PubMed
Publication date: 2025/01/02
Shan YupingHu HongYang AnningZhao WendiChu Yijing - To investigate the serum biomarkers in patients with drug-resistant epilepsy (DRE). - Source: PubMed
Publication date: 2024/03/22
Ma MianCheng YingHou XiaoxiaLi ZhisenWang MeixiaMa BodunCheng QingzhangDing ZhiliangFeng Hongxuan - Multiple myeloma (MM) is an incurable plasma cell malignancy, and International Staging System (ISS) is used to predict the outcomes of MM patients. However, ISS stage is imperfect, and there might exist other factors correlated with prognosis of MM patients. Expression profiles and clinical information of 340 newly diagnosed MM patients from GEO database and 105 newly diagnosed MM patients from our hospital were analyzed, and LASSO regression was used to screen genes associated with both overall survival and progression-free survival of MM patients. Nomogram was constructed to predict outcomes of MM patients. Then, CCK8 and transwell assays were used to evaluate the proliferation and migration ability of MM cells; flow cytometry was performed to verify whether MM cells underwent necroptosis. Quantitative real-time PCR and western blot were performed to evaluate gene expressions. We found that KIAA1191 was associated with both overall survival and progression-free survival of MM patients. Furthermore, KIAA1191 high expression suppressed the proliferation and migration of MM cells; upregulated the expression of RIP1, RIP3, and CYLD, and restored the TNF-α/z-VAD-induced necroptosis. Besides, KIAA1191 overexpression had a synergistic effect with bortezomib on the proliferation capability of MM cells. - Source: PubMed
Publication date: 2022/01/06
Xu ZhaoSun YifengJiang JifengLiu Peng - The novel protein p33MONOX (p33Monooxygenase) was over-expressed in neuroblastoma cells demonstrating its inhibitory effect on the phosphorylation of the App (amyloid precursor protein) and Bcl2 (B-cell lymphoma 2) proteins but mediating higher activation of Mapk1/3 (mitogen-activated protein kinase 1/3). We employed a variety of cell biology techniques to show the localization of p33MONOX to the cytoplasm of pyramidal neurons in the mouse brain hippocampus. We also carried out a yeast-two-hybrid screening plus co-immunoprecipitation and bio-informatics to determine COBRA1 (cofactor of BRCA1 (breast cancer type 1)), NOL12 (nucleolar protein 12), and PRNP (prion protein) as p33MONOX-interacting proteins. Bio-computational analyses revealed a flavine-containing monooxygenase (FMO)-1 motif, thus linking p33MONOX to a group of previously characterized proteins, the MICALs (molecule interacting with CasL). Concluding, p33MONOX might regulate pre- and post-transcriptional control of dynamic processes related to growth cone guidance. - Source: PubMed
Publication date: 2010/12/14
Mishra ManishaInoue NorikoHeese Klaus