Ask about this productRelated genes to: ODF2L antibody
- Gene:
- ODF2L NIH gene
- Name:
- outer dense fiber of sperm tails 2 like
- Previous symbol:
- -
- Synonyms:
- KIAA1229
- Chromosome:
- 1p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-08-17
- Date modifiied:
- 2016-04-25
Related products to: ODF2L antibody
Related articles to: ODF2L antibody
- Diabetic retinopathy (DR) represents the predominant etiology of visual impairment and blindness on a global scale. At present, there is still a dearth of robust biomarkers for DR, which substantially limits its diagnosis, particularly at an early stage. Tears, owing to their inherent proximity to the ocular microenvironment, offer a unique advantage as a source of potential biomarkers for retinal pathologies. Specifically, tear-derived extracellular vesicles (tEVs) have emerged as promising candidates for this purpose, given their ability to reflect the physiological and pathological states of the retina. In this study, we conducted a comprehensive transcriptomic analysis of tEVs and identified a panel of tEV-mRNAs including ODF2L, TSR1, TONSL, and FUT6 as potential biomarkers for the diagnosis of DR. We validated this finding by using 119 tear samples from healthy controls and individuals with varying degrees of retinopathy. Considering the noninvasive and straightforward nature of tear fluid collection, the identified tEV-mRNAs hold significant promise for facilitating the early, noninvasive diagnosis and subsequent management of DR. - Source: PubMed
Publication date: 2025/09/04
Chen JiamingZhang ZhaoweiHong XiaoqinKang JingjingZhang WanchaoDu RuiXu JiaDing ZhaofengLi ChangLiu Dingbin - Observational studies indicate that variations in peripheral blood mononuclear cell (PBMC) subsets are associated with an increased risk of pulmonary tuberculosis (PTB) and coronavirus disease 2019 (COVID-19), but causal validation is lacking. Here, we combined single-cell expression quantitative trait locus (sc-eQTL) and two-sample mendelian randomization (MR) analyses to elucidate the causal relationship between PBMC subsets and the occurrence of PTB and COVID-19 and verified by RT-qPCR. We observed an increase in the CD4 Effective Memory T Cell (CD4 T) cluster in both PTB and COVID-19 patients according to the single-cell transcriptional landscape of PBMC. Through MR analysis using an inverse variance weighted (IVW) method, we found strong evidence of positive correlations between CD4 T cell markers (GBP2, TRAV1-2, and ODF2L) and PTB, and between markers (LAG3 and SLFN5) and COVID-19, especially highlighted by lead eQTL-SNPs of GBP2 (rs2256752, = 4.76321 × 10) and LAG3 (rs67706382, = 6.16× 10). Similar results were observed in validation sets, and no pleiotropy was detected in sensitivity analyses including weighted median (WM), MR-Egger, MR-pleiotropy residual sum and outlier, and leave-one-out analyses (all > 0.05). We visualized the colocalization of marker-eQTLs and markers of PTB and COVID-19 genome-wide association study (GWAS) associations. Based on CellChat analyses, monocytes communicated predominantly with CD4 T cells positively expressing PTB markers (GBP2, TRAV1-2, and ODF2L) and COVID-19 markers (LAG3 and SLFN5) in both PTB and COVID-19. Our data suggest a causal effect between two key CD4 T cell markers (GBP2 and LAG3) and the risk for PTB and COVID-19 infection. Our findings provide novel insights into the biological mechanism for PTB and COVID-19 infection, but future single-cell studies are necessary to further enhance understanding of this find. - Source: PubMed
Publication date: 2024/09/16
Zhu LiangyuWu HanxinPeng LiHuang XunYang RuiMa WeijieZhong LeiLi BingxueSong JieqinLuo SuyiGao LiWu XinyaMa WeijiangBao FukaiLiu Aihua - Primary cilia are antenna-like organelles that conduct physical and chemical signals, which affect cell proliferation, migration, and differentiation. Some researchers have reported the correlation between primary cilia-related genes and prognosis of colorectal cancer (CRC). - Source: PubMed
Qiu LeiChen SiluBen ShuaiCui JinxinLu ShanQu RongLv JinghuanShao WeiYu Qiang - WEE1 has emerged as an attractive target in epithelial ovarian cancer (EOC), but how EOC cells may alter their sensitivity to WEE1 inhibition remains unclear. Here, through a cell cycle machinery-related gene RNAi screen, we found that targeting outer dense fiber of sperm tails 2-like (ODF2L) was a synthetic lethal partner with WEE1 kinase inhibition in EOC cells. Knockdown of ODF2L robustly sensitized cells to treatment with the WEE1 inhibitor AZD1775 in EOC cell lines in vitro as well as in xenografts in vivo. Mechanistically, the increased sensitivity to WEE1 inhibition upon ODF2L loss was accompanied by accumulated DNA damage. ODF2L licensed the recruitment of PKMYT1, a functionally redundant kinase of WEE1, to the CDK1-cyclin B complex and thus restricted the activity of CDK1 when WEE1 was inhibited. Clinically, upregulation of ODF2L correlated with CDK1 activity, DNA damage levels, and sensitivity to WEE1 inhibition in patient-derived EOC cells. Moreover, ODF2L levels predicted the response to WEE1 inhibition in an EOC patient-derived xenograft model. Combination treatment with tumor-targeted lipid nanoparticles that packaged ODF2L siRNA and AZD1775 led to the synergistic attenuation of tumor growth in the ID8 ovarian cancer syngeneic mouse model. These data suggest that WEE1 inhibition is a promising precision therapeutic strategy for EOC cells expressing low levels of ODF2L. - Source: PubMed
Publication date: 2023/01/17
Li JieLu JingyiXu ManmanYang ShiyuYu TiantianZheng CuimiaoHuang XiPan YuwenChen YangyangLong JunmingZhang ChunyuHuang HuaDai QingyuanLi BoWang WeiYao ShuzhongPan Chaoyun - The Toll-interleukin-1 Receptor (TIR) domain-containing adaptor protein (TIRAP) represents a key intracellular signalling molecule regulating diverse immune responses. Its capacity to function as an adaptor molecule has been widely investigated in relation to Toll-like Receptor (TLR)-mediated innate immune signalling. Since the discovery of TIRAP in 2001, initial studies were mainly focused on its role as an adaptor protein that couples Myeloid differentiation factor 88 (MyD88) with TLRs, to activate MyD88-dependent TLRs signalling. Subsequent studies delineated TIRAP's role as a transducer of signalling events through its interaction with non-TLR signalling mediators. Indeed, the ability of TIRAP to interact with an array of intracellular signalling mediators suggests its central role in various immune responses. Therefore, continued studies that elucidate the molecular basis of various TIRAP-protein interactions and how they affect the signalling magnitude, should provide key information on the inflammatory disease mechanisms. This review summarizes the TIRAP recruitment to activated receptors and discusses the mechanism of interactions in relation to the signalling that precede acute and chronic inflammatory diseases. Furthermore, we highlighted the significance of TIRAP-TIR domain containing binding sites for several intracellular inflammatory signalling molecules. Collectively, we discuss the importance of the TIR domain in TIRAP as a key interface involved in protein interactions which could hence serve as a therapeutic target to dampen the extent of acute and chronic inflammatory conditions. - Source: PubMed
Publication date: 2021/07/08
Rajpoot SajjanWary Kishore KIbbott RachelLiu DongfangSaqib UzmaThurston Teresa L MBaig Mirza S