Ask about this productRelated genes to: ZCCHC13 antibody
- Gene:
- ZCCHC13 NIH gene
- Name:
- zinc finger CCHC-type containing 13
- Previous symbol:
- -
- Synonyms:
- 4930513O09RIK, Cnbp2, ZNF9L
- Chromosome:
- Xq13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-08-19
- Date modifiied:
- 2016-02-12
Related products to: ZCCHC13 antibody
Related articles to: ZCCHC13 antibody
- Idiopathic nonobstructive azoospermia (iNOA) is defined as the absence of sperm in the ejaculate with no identifiable cause after thorough physical, hormonal, and genetic evaluations. This study aimed to investigate the differential gene expression of key epigenetic regulators--in patients with iNOA compared with those with obstructive azoospermia (OA). Sixty infertile men diagnosed with azoospermia were equally divided into iNOA (case group) and OA (control group). Participants with iNOA were further subdivided into iNOA⁺ (successful sperm retrieval, = 10) and iNOA⁻ (unsuccessful retrieval, = 20) based on microdissection testicular sperm extraction (micro-TESE) outcomes. The relative expression of , and was analyzed in testicular tissue samples using quantitative real-time PCR. Expression levels of and were significantly lower in the iNOA group compared with OA ( = .01), while expression was significantly higher in iNOA, particularly in the iNOA⁻ subgroup ( < .0001). Receiver operating characteristic (ROC) analysis revealed DNMT3B had the highest diagnostic accuracy (AUC = 0.84, < .0001), followed by ZCCHC13 (Area under the curve (AUC) = 0.69) and DNMT1 (AUC = 0.68). Our findings indicate that epigenetic dysregulation contributes to impaired spermatogenesis in iNOA, which can be molecularly distinguished from OA. Epigenetic biomarkers such as and may offer reliable diagnostic tools for idiopathic cases of azoospermia and serve as potential targets for future epigenetic therapies. - Source: PubMed
Publication date: 2025/11/17
Firouzabadi Amir MasoudHarimi SamanehHeydari ParisaDemehri FarangisMirghanizadeh Bafghi Seyyed Amir HosseinFesahat Farzaneh - Non-obstructive azoospermia (NOA) is considered one of the most severe forms of male infertility. Despite the limited range of testicular phenotypes, NOA exhibits considerable genetic heterogeneity. The aim of this study was to uncover the etiopathogenesis of NOA and provide insights into the outcomes of testicular sperm extraction (TESE). - Source: PubMed
Publication date: 2025/02/11
Sharifi ShahrashoubDursun MuratŞahin AylaTuran SerdarAltun AyşeÖzcan ÖzdenKalkanlı ArifÇefle KıvançÖztürk ŞükrüPalanduz ŞükrüKadıoğlu Ateş - We used a hybrid machine learning systems (HMLS) strategy that includes the extensive search for the discovery of the most optimal HMLSs, including feature selection algorithms, a feature extraction algorithm, and classifiers for diagnosing breast cancer. Hence, this study aims to obtain a high-importance transcriptome profile linked with classification procedures that can facilitate the early detection of breast cancer. - Source: PubMed
Publication date: 2022/10/01
Taghizadeh EskandarHeydarheydari SahelSaberi AlihosseinJafarpoorNesheli ShabnamRezaeijo Seyed Masoud - The role of sperm expressed X-linked genes on bull fertility has not been studied in detail. The objective of the present study was to assess the influence of X-linked genes on the sperm functional parameters and field fertility rate in the Holstein Friesian cattle (n = 12) and Murrah buffalo (n = 7) bulls. The enrichment analysis (cattle = 8; buffalo = 8) of the X-linked genes was carried out using retrospective RNA-seq data and mRNA expression levels of functionally relevant genes were validated using the RT-qPCR. The mRNA expression levels of these genes were functionally associated with sperm attributes and field fertility rate. The sperm transcriptome studies revealed that the total number of expressed genes and the transcript content of the X-linked genes in the mature sperm were very low in both species, and only 23.31% of these genes were commonly expressed between them. The transcript pool corresponding to the X-linked genes represents embryonic organ development (p = 0.03) and reproduction (p = 0.02) processes in cattle and buffalo sperm, respectively. The mRNA expression levels of X-linked genes, RPL10 and ZCCHC13 in cattle; AKAP4, TSPAN6, RPL10 and RPS4X in buffalo were significantly (p < 0.05) correlated with sperm kinematics. Importantly, the mRNA expression levels of the genes RPL10 (r = -0.68) and RPS4X (r = 0.81) had a significant correlation with the field fertility rate in cattle and buffalo, respectively. Multivariate regression models and receiver operating curve analysis suggest that the mRNA expression levels of X-linked genes may be useful in predicting bull fertility. The study indicates that sperm-expressed X-linked genes influence semen quality and field fertility rate in both cattle and buffalo. - Source: PubMed
Publication date: 2022/07/11
Swathi DivakarRamya LaxmanArchana Santhanahalli SiddalingappaLavanya MaharajanKrishnappa BalaganurBinsila Bala KrishnanSelvaraju Sellappan - Previous studies have shown that zinc-finger CCHC-type containing 13 (ZCCHC13) is located in an imprinted gene cluster in the X-inactivation centre, but few published studies have provided evidence of its expression in cancers. The CCHC-type zinc finger motif has numerous biological activities (such as DNA binding and RNA binding) and mediates protein-protein interactions. In an effort to examine the clinical utility of ZCCHC13 in oncology, we investigated the expression of the ZCCHC13 mRNA and protein in hepatocellular carcinoma (HCC). - Source: PubMed
Publication date: 2019/04/02
Li ZhimingLi ZhiWang LinjunLong ChenZheng ZaozaoZhuang Xuan