Ask about this productRelated genes to: MGC70924 antibody
- Gene:
- PRR19 NIH gene
- Name:
- proline rich 19
- Previous symbol:
- -
- Synonyms:
- MGC70924
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2007-12-17
- Date modifiied:
- 2014-11-19
Related products to: MGC70924 antibody
Related articles to: MGC70924 antibody
- Orderly chromosome segregation is enabled by crossovers between homologous chromosomes in the first meiotic division. Crossovers arise from recombination-mediated repair of programmed DNA double-strand breaks (DSBs). Multiple DSBs initiate recombination, and most are repaired without crossover formation, although one or more generate crossovers on each chromosome. Although the underlying mechanisms are ill-defined, the differentiation and maturation of crossover-specific recombination intermediates requires the cyclin-like CNTD1. Here, we identify PRR19 as a partner of CNTD1. We find that, like CNTD1, PRR19 is required for timely DSB repair and the formation of crossover-specific recombination complexes. PRR19 and CNTD1 co-localise at crossover sites, physically interact, and are interdependent for accumulation, indicating a PRR19-CNTD1 partnership in crossing over. Further, we show that CNTD1 interacts with a cyclin-dependent kinase, CDK2, which also accumulates in crossover-specific recombination complexes. Thus, the PRR19-CNTD1 complex may enable crossover differentiation by regulating CDK2. - Source: PubMed
Publication date: 2020/06/18
Bondarieva AnastasiiaRaveendran KavyaTelychko VladyslavRao H B D PrasadaRavindranathan RamyaZorzompokou ChrysoulaFinsterbusch FriederikeDereli IhsanPapanikos FrantzeskosTränkner DanielSchleiffer AlexanderFei Ji-FengKlimova AnnaIto MasaruKulkarni Dhananjaya SRoeder IngoHunter NeilTóth Attila