Ask about this productRelated genes to: HDDC3 antibody
- Gene:
- HDDC3 NIH gene
- Name:
- HD domain containing 3
- Previous symbol:
- -
- Synonyms:
- MGC45386
- Chromosome:
- 15q26.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-08-22
- Date modifiied:
- 2014-11-19
Related products to: HDDC3 antibody
Related articles to: HDDC3 antibody
- Biological sulfation reactions require 3'-phosphoadenosine-5'-phosphosulfate (PAPS) as the universal sulfate donor. While the biosynthetic pathway of PAPS has been well characterized, the phosphatase degrading PAPS remains unidentified. Here, we discover MESH1 as a PAPS phosphatase that hydrolyzes PAPS into adenosine-5'-phosphosulfate and phosphate. Our crystallographic analysis of the MESH1-PAPS complex confirms PAPS as a bona fide substrate of MESH1. We further show that MESH1 localizes to Golgi, where sulfotransferases consume PAPS to produce sulfated glycosaminoglycan (sGAG). We show that MESH1 (also known as HDDC3) knockdown enhances sGAG production in a chondrogenic cell line. Furthermore, in brachymorphic mice, Mesh1 knockout significantly elevates sGAG levels in joint cartilage and improves bone density. In Caenorhabditis elegans lacking bpnt-1, neurotoxic PAP accumulation is alleviated by MESH1 overexpression, reducing upstream PAPS levels. Our biochemical, structural and functional findings establish MESH1 as a key PAPS phosphatase and highlights its potential as a therapeutic target in disorders characterized by sulfation deficiency. - Source: PubMed
Publication date: 2026/04/10
Lin Chao-ChiehRose JoshuaZhang AlbertMirando Anthony JMestre Alexander ADing Chien-Kuang CorneliaLiao YihanChen Ssu-YuSetayeshpour YasamanWu JianliLi ZhongYan DongHilton Matthew JZhou PeiChi Jen-Tsan - Ferroptosis is a regulated form of cell death driven by iron-dependent lipid peroxidation and contributes to diverse pathologies including ischemia-reperfusion injury and neurodegenerative disorders. Current ferroptosis inhibitors largely function as nonspecific radical-trapping antioxidants, limiting their clinical utility. We previously identified MESH1 as a key regulator of ferroptosis through its NADPH phosphatase activity. Here, we identify 4,5,6,7-tetrabromo-1-benzotriazole (TBB) as a small molecule inhibitor of MESH1 with an IC value of 4.7 ± 0.3 μM. X-ray crystallography revealed the molecular determinants of TBB recognition which are corroborated through structure-activity relationships of TBB analogs. TBB protected multiple cell lines against ferroptosis , and this effect was mitigated by knockdown, consistent with on-target activity. Furthermore, TBB reduced neuronal death in an brain slice model of Alzheimer's disease. Collectively, these findings establish TBB as a small-molecule MESH1 inhibitor that suppresses ferroptosis and establishes MESH1 as a promising therapeutic target. - Source: PubMed
Publication date: 2026/02/20
Mestre Alexander AOh YunjuWu JianliDunn DeniseSetayeshpour YasamanChen Ssu-YuLin Chao-ChiehCochrane C SkylerJeong PyeonghwaNam GibeomMarkey ChloeReker DanielFloyd Scott RHong JiyongZhou PeiChi Jen-Tsan - Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders, affecting 8–13% of women of reproductive age. Its heterogeneous presentation and the variability of diagnostic criteria make accurate diagnosis and effective management challenging. Artificial intelligence (AI) methods, including machine learning (ML), deep learning (DL), explainable AI (XAI), and large language models (LLMs), have recently emerged as promising approaches to address these gaps. - Source: PubMed
Publication date: 2025/11/24
Ghaderzadeh MustafaGaravand AliSalehnasab Cirruse - Freshwater resources are scarce in arid regions, and the rational use of brackish water resources can alleviate local freshwater shortages, but long-term brackish drip irrigation increases the risk of soil salinization, which in turn affects soil nutrient transformation and microbial diversity. Soil phosphorus availability is critical for crop growth, yet it is unclear how long-term brackish drip irrigation will affect soil phosphorus transformation. Therefore, to investigate the effects of long-term brackish drip irrigation on soil phosphorus-transforming microorganisms and their functional genes in cotton fields, the experiment was set up with two irrigation water salinities, freshwater （0.35 dS·m, FW） and brackish water （8.04 dS·m, SW）. The results showed that long-term brackish drip irrigation significantly decreased cotton dry matter weight, phosphorus uptake, yield, soil pH, and Ca-P and Ca-P contents but significantly increased cotton phosphorus content and soil water content； electrical conductivity； quick phosphorus； and Ca-P, Al-P, Fe-P, and O-P contents. The dominant species in each treatment at the phylum level were Ascomycetes, Actinobacteria, Acidobacteria, Bacillus, and Greenscapes； and at the phylum level, the dominant species were -Ascomycetes, Actinobacteria, -Ascomycetes, Oleococcus thermophilus, and -Ascomycetes. including Proteobacteria, Actinobacteria, Acidobacteria, Gemmatimonadetes, and Chloroflexi. Select dominant species at the class level included Alphaproteobacteria, Actinomycetia, Betaproteobacteria, Thermoleophilia, and Gammaproteobacteria. Long-term saline drip irrigation significantly reduced the relative abundance of Actinobacteria, Acidobacteria, and Nitrospirae but significantly increased the relative abundance of Proteobacteria, Gemmatimonadetes, and Bacteroidetes and significantly reduced the expression levels of the organic phosphorus mineralization gene , transport gene , and polyphosphate synthesis gene . Moreover, it significantly increased the expression levels of the polyphosphate degradation gene ； organic phosphorus mineralization genes , , , , , , , and ； transport genes , , , and ； and the regulatory gene . Correlation analysis showed that soil phosphorus-cycling microorganisms and functional genes were closely related to soil physicochemical properties and soil inorganic phosphorus content. Therefore, long-term saline drip irrigation changes the composition of soil phosphorus-cycling microorganisms by affecting soil physical and chemical properties and inorganic phosphorus content, which in turn drives the expression of phosphorus-cycling-related functional genes to regulate and adapt to salt stress. - Source: PubMed
Ye YangGuo Xiao-WenYang Mao-QiMin WeiGuo Hui-Juan - Ischemic stroke (IS) is a major cause of disability and mortality worldwide. Increasing evidence suggests a strong association between blood pressure, blood glucose, circulating lipids, and IS. Nonetheless, the genetic association of these 3 risk factors with IS remains elusive. - Source: PubMed
Publication date: 2024/04/09
Liu YiWang WeiliCui XinLyu JianXie Yanming