Ask about this productRelated genes to: LTB4DH antibody
- Gene:
- PTGR1 NIH gene
- Name:
- prostaglandin reductase 1
- Previous symbol:
- LTB4DH
- Synonyms:
- ZADH3
- Chromosome:
- 9q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-09-19
- Date modifiied:
- 2016-10-05
Related products to: LTB4DH antibody
Related articles to: LTB4DH antibody
- Egg production is an essential metric used to assess poultry reproductive efficiency. The liver, functioning as a vital metabolic organ, is integral to avian reproduction and the overall productivity of laying birds. In this research, we aimed to explore various aspects of the mechanisms behind egg production across different poultry species by conducting transcriptomic and metabolomic analyses, as well as integrated assessments, of liver tissues from high- and low-producing pigeons to investigate the biosynthesis processes and identify pivotal genes and metabolic pathways in the liver during egg production. There were 1380 differentially expressed genes (DEGs) identified between the low- and high-production groups. The low-production group had 670 upregulated and 710 downregulated genes. Five genes identified were linked to egg production in the transcriptome: PRLR, HMGCR, CDK6, PTGR1 and RBPJ. The pathways that were identified to be the most significant encompass cytokine-cytokine receptor interaction, PI3K-AKT and JAK-STAT signalling pathways. Of the 229 significantly differentially abundant metabolites (DAMs) identified, 71 were upregulated, and 158 were downregulated, of which forskolin, methionine, prostaglandin F2α and adenosine 5'-diphosphate emerged as key metabolites associated with reproduction. By integrating transcriptomic and metabolomic data, we uncovered correlations between specific DEGs and DAMs, revealing significant gene-metabolite pairs, namely, PRLR-prostaglandin F2α and PRLR-adenosine 5'-diphosphate, involved in egg production. The new knowledge substantially enhances our comprehension of the molecular distinctions in hepatic physiology of high- and low-producing pigeons and establishes a valuable theoretical framework for future investigations into the mechanistic basis of avian egg-laying performance. - Source: PubMed
Publication date: 2026/04/21
Chen HuiZhang BinWang ManmanFu YiqianLi JingZhao KailingChen YufeiSong YujieLi YunhaiXu ShanjinDai Dingzhen - Chronic inflammatory diseases, such as ulcerative colitis (UC), Crohn's disease (CD), Alzheimer's disease (AD) and Parkinson's disease (PD) are clinically related to periodontitis. However, the computation of omic biomarkers regarding these diseases has not leveraged this association. - Source: PubMed
Publication date: 2026/04/21
Wang XingyuLiu LeiYang FanHuang ChulingMei ZiyiLi JieMa Shiyong - Sirtuin 6 (SIRT6) possesses both deacetylation and mono-ADP-ribosyltransferase activities, affecting diverse biological processes via interaction with cellular substrates. However, the role of SIRT6 in female reproductive functions is largely unknown. This study examined the expression, regulation, and role of SIRT6 in the uterus of early pregnant pigs. - Source: PubMed
Publication date: 2026/02/04
Szymanska MagdalenaBlitek AgnieszkaMyszczynski Kamil - Aristolochic acids (AAs) are natural compounds found in Aristolochiaceae plants, to which humans are frequently exposed through environmental and medicinal sources. AAs are highly nephrotoxic and carcinogenic, mediated by oxidative stress and bioactivation-induced DNA damage and mutagenicity. Nevertheless, some Lepidoptera, including Pachliopta aristolochiae, feed exclusively on Aristolochiaceae and sequester AAs as a chemical defense. This is uncommon in nature and it is not yet fully understood how these insects avoid the lethal effects of AAs. To address this question, we investigate Pac. aristolochiae's AA-resistance mechanisms by employing metabolic analyses, multiomics analyses, in situ imaging and more. Our findings indicate that AAs may be detoxified through biotransformation and a robust antioxidant system, involving candidate genes such as 15-oxo-prostaglandin 13-reductases (PGRs), cytochrome P450s, and catalases. Unexpectedly, DNA adducts, the covalent binding products from activated AA intermediates, are detected across most life stages of Pac. aristolochiae, revealing that Pac. aristolochiae can maintain genomic integrity despite a substantial burden (reaching over 1800 AA-DNA adducts per 10 nucleotides in adults, approximately 1 adduct per 55 000 nucleotides). Interestingly, however, no detectable DNA adducts are observed in wing discs, a representative organ undergoing metamorphosis, and AAs in testes are confined to somatic but not germ cells. Therefore, the strategies to protect against AA-induced mutagenicity likely include restricted AA distribution in critical tissues and enhanced DNA repair. Using butterflies as an evolutionary model, we identify PTGR1, the human PGR homolog, as a potential target of AA resistance, which is associated with human acute kidney injury. Validation in human cells further demonstrates its role in reducing AA-induced cytotoxicity and lipid peroxidation. Our study highlights insect AA tolerance as a means to discover human protective mechanisms, thereby suggesting new avenues for preventing AA-related diseases. - Source: PubMed
Publication date: 2026/01/04
Luan YangZhang YuboLi JingjingZhu JianqingLei YuyangHu YushiXin ZhenqiangXie TianpeiZheng JiangLin YuanyuanShen JingjingCao YiyiYou XinyueXi JingWu JiayingLiu WeiyingZhang XinyuZheng YuantingLohman David JShi LemingZhang Wei - The gut microbiome is crucial in regulating overall physiology and communicates with the host through various microbial-derived metabolites, including secondary bile acids (BAs). However, mechanisms underlying the gut microbiome-BA crosstalk (gMxB) are still poorly understood. Here, we assess the postprandial cecal microbiome, BA levels, and colon transcriptome of male BXD mice fed with a chow or high-fat diet, and find that genetic and dietary factors shift microbiome composition and affect gMxB. Four diet-dependent co-mapping genetic loci associated with gMxB, including the interaction between Turicibacter sanguinis - plasma cholic acid, are identified using systems genetics approaches. By integrating human MiBioGen database, we prioritize PTGR1 and PTPRD as candidate genes potentially regulating identified gMxB. The human relevance of these candidates on metabolic health is investigated using data from the UK biobank, FinnGen, and million veteran program databases. Overall, this study illustrates potential modulators regulating gMxB and provides insights into gut microbiome-host communication. - Source: PubMed
Publication date: 2025/12/18
Li XiaoxuPerino AlessiaSulc JonathanJalil Antoinevon Alvensleben Giacomo V GMorel Jean-DavidWang QiRapin AlexisLi HaoSchoonjans KristinaAuwerx Johan