Ask about this productRelated genes to: THAP5 antibody
- Gene:
- THAP5 NIH gene
- Name:
- THAP domain containing 5
- Previous symbol:
- -
- Synonyms:
- DKFZp313O1132
- Chromosome:
- 7q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-08
- Date modifiied:
- 2016-10-05
Related products to: THAP5 antibody
Related articles to: THAP5 antibody
- Schizophrenia (SCZ) is increasingly recognized as a complex, systemic disorder involving interactions between the central nervous system and peripheral biological processes. Growing evidence implicates dysregulation of the gut-brain axis in SCZ pathophysiology; however, the genetic mechanisms linking schizophrenia susceptibility to gut-related biological pathways remain poorly understood, particularly with respect to causal gene prioritization across tissues. - Source: PubMed
Publication date: 2026/01/28
Yu LingChen JianDu ShanshanLong QingGuo ZeyiLiu YilinQin FuyiWang MengxueLuo RaoxiangZhang YunqiaoZeng YongTeng Zhaowei - Serine/arginine protein kinase 1 phosphorylates serine-arginine-rich (SR) proteins to regulate splice-site selection during alternative splicing. While its role in general RNA regulation is established, its contribution to the HPV-dependent transcriptome and splicing stratification in cervical cancer remains unclear. Therefore, we sought to determine how SRPK1 inhibition differentially remodels gene expression and alternative splicing in HPV versus HPV cervical cancer cells. - Source: PubMed
Publication date: 2026/01/02
Basera AfraAlaouna MohammedDuvenhage JanieBates David ODlamini ZodwaMarima Rahaba - De novo mesenchymal-to-epithelial transition (MET) gene fusions in non-small cell lung cancer (NSCLC) are a promising target for MET tyrosine kinase inhibitors (TKIs). We aimed to examine the response to targeted therapy with MET TKIs and resistance mechanisms in de novo MET fusion-positive NSCLC as these have not been comprehensively explored. - Source: PubMed
Publication date: 2023/02/01
Kang JinDeng Qiu-MeiFeng WeinengChen Zi-HaoSu Jun-WeiChen Hua-JunWang Wen-XianZhang ShirongWang QianChen ZexinZhong Wen-ZhaoXu Chun-WeiYang Jin-Ji - Scutellaria baicalensis is a commonly used Chinese medicinal herb. In this study, we identified the germplasm resources of commercial S. baicalensis samples based on trnH-psbA, petA-psbJ, and ycf4-cemA sequences according to the available chloroplast genome sequencing results, and measured the content of baicalin by HPLC. Through the above means we determined the best DNA barcode that can be used to detect the germplasm resources and evaluate the quality of commercial S. baicalensis samples. A total of 104 samples were collected from 24 provinces, from which DNA was extracted for PCR amplification. The amplification efficiencies of trnH-psbA, petA-psbJ, and ycf4-cemA sequences were 100%, 59.62%, and 25.96%, respectively. The results of sequence analysis showed that 5, 4, and 2 haplotypes were identified based on trnH-psbA, petA-psbJ, and ycf4-cemA sequences, respectively. However, the sequences of haplotypes in commercial samples were different from that of the wild type, and the joint analysis of three fragments of S. baicalensis only identified 6 haplotypes. Furthermore, the phylogenetic analysis and genetic distance analysis indicated that trnH-psbA could be used to identify S. baicalensis from adulterants. The above analysis showed that trnH-psbA was the best fragment for identifying the germplasm resources of commercial S. baicalensis samples. We then analyzed the haplotypes(THap1-THap5) of commercial S. baicalensis samples based on trnH-psbA and found that THap2 was the main circulating haplotype of the commercial samples, accounting for 86.55% of the total samples, which indicated the scarce germplasm resources of commercial S. baicalensis samples. The content of baicalin in all the collected commercial S. baicalensis samples exceeded the standard in Chinese Pharmacopoeia and had significant differences(maximum of 12.21%) among samples, suggesting that the quality of commercial S. baicalensis samples varied considerably. However, there was no significant difference in baicalin content between different provinces or between different haplotypes. This study facilitates the establishment of the standard identification system for S. baicalensis, and can guide the commercial circulation and reasonable medication of S. baicalensis. - Source: PubMed
Zhang Jing-HanLiu Shan-HuZhang Zhi-FeiShi YueMan Jin-HuiYin Guang-YaoWang XinLiu Feng-BoWang Xiao-HuiWei Sheng-Li - The most prolific duck genetic resource in the world is located in Southeast/South Asia but little is known about the domestication and complex histories of these duck populations. - Source: PubMed
Publication date: 2021/04/13
Jiang FanLin RuiyiXiao ChangyiXie TanghuiJiang YaoxinChen JianhaiNi PanSung Wing-KinHan JianlinDu XiaoyongLi Shijun