Ask about this productRelated genes to: FAM81A antibody
- Gene:
- FAM81A NIH gene
- Name:
- family with sequence similarity 81 member A
- Previous symbol:
- -
- Synonyms:
- MGC26690
- Chromosome:
- 15q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-10-21
- Date modifiied:
- 2019-02-11
Related products to: FAM81A antibody
Related articles to: FAM81A antibody
- Gastric cancer (GC) is a common malignancy with poor prognosis and lack of efficient therapeutic methods. Shen Qing Weichang Formula (SQWCF) is a patented traditional herbal prescription for GC, but its efficacy and underlying mechanism remains to be clarified. - Source: PubMed
Publication date: 2025/03/29
Wang YiSun XiaoyuRen MingmingMa FangqiZhao RuohanZhu XiaohongXu YanCao NidaChen YuanyuanPan YongfuZhao Aiguang - The aims of this study were to screen for phagocytosis regulator-related genes in tissue samples from children with medulloblastoma (MB) and to construct a prognostic model based on those genes. - Source: PubMed
Publication date: 2024/07/10
Han GuoqingWang XingdongPu KeLi ZhenhangLi QingguoTong Xiaoguang - Deeper insights into ERBB2-driven cancers are essential to develop new treatment approaches for ERBB2+ breast cancers (BCs). We employed the Collaborative Cross (CC) mouse model to unearth genetic factors underpinning Erbb2-driven mammary tumour development and metastasis. - Source: PubMed
Publication date: 2024/07/26
Yang HuiWang XinzhiBlanco-Gómez AdriánHe LiGarcía-Sancha NataliaCorchado-Cobos RobertoPérez-Baena Manuel JesúsJiménez-Navas AlejandroWang PinInman Jamie LSnijders Antoine MThreadgill David WBalmain AllanChang HangPerez-Losada JesusMao Jian-Hua - Cardiovascular diseases (CVDs) comprise major causes of death worldwide, leading to extensive burden on populations and societies. Alterations in normal lipid profiles, i.e., dyslipidemia, comprise important risk factors for CVDs. However, there is lack of comprehensive evidence on the genetic contribution to dyslipidemia in highly admixed populations. The identification of single nucleotide polymorphisms (SNPs) linked to blood lipid traits in the Brazilian population was based on genome-wide associations using data from the São Paulo Health Survey with Focus on Nutrition (ISA-Nutrition). - Source: PubMed
Publication date: 2024/07/26
Leite Jean Michel R SPereira Jaqueline LAlves de Souza CamilaPavan Soler Júlia MMingroni-Netto Regina CéliaFisberg Regina MRogero Marcelo MSarti Flavia M - Proteome analyses of the postsynaptic density (PSD), a proteinaceous specialization beneath the postsynaptic membrane of excitatory synapses, have identified several thousands of proteins. While proteins with predictable functions have been well studied, functionally uncharacterized proteins are mostly overlooked. In this study, we conducted a comprehensive meta-analysis of 35 PSD proteome datasets, encompassing a total of 5,869 proteins. Employing a ranking methodology, we identified 97 proteins that remain inadequately characterized. From this selection, we focused our detailed analysis on the highest-ranked protein, FAM81A. FAM81A interacts with PSD proteins, including PSD-95, SynGAP, and NMDA receptors, and promotes liquid-liquid phase separation of those proteins in cultured cells or in vitro. Down-regulation of FAM81A in cultured neurons causes a decrease in the size of PSD-95 puncta and the frequency of neuronal firing. Our findings suggest that FAM81A plays a crucial role in facilitating the interaction and assembly of proteins within the PSD, and its presence is important for maintaining normal synaptic function. Additionally, our methodology underscores the necessity for further characterization of numerous synaptic proteins that still lack comprehensive understanding. - Source: PubMed
Publication date: 2024/03/07
Kaizuka TakeshiHirouchi TaiseiSaneyoshi TakeoShirafuji ToshihikoCollins Mark OGrant Seth G NHayashi YasunoriTakumi Toru