Ask about this productRelated genes to: C11ORF74 antibody
- Gene:
- C11orf74 NIH gene
- Name:
- chromosome 11 open reading frame 74
- Previous symbol:
- -
- Synonyms:
- FLJ38678, HEPIS, NWC
- Chromosome:
- 11p12
- Locus Type:
- gene with protein product
- Date approved:
- 2006-03-16
- Date modifiied:
- 2018-12-03
Related products to: C11ORF74 antibody
Related articles to: C11ORF74 antibody
- Zinc finger protein 384 () encodes a C2H2-type zinc finger protein that can function as a transcription factor. ZNF384 rearrangement in acute lymphoblastic leukemia (ALL) was first reported in 2002. More than 19 different ZNF384 fusion partners have been detected in ALL. These include E1A-binding protein P300 (), CREB-binding protein (), transcription factor 3 (), TATA-box binding protein associated factor 15 (), Ewing sarcoma breakpoint region 1 gene (), AT-rich interactive domain-containing protein 1B (), SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4 (), SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 2 (), synergin gamma (), clathrin heavy chain (), bone morphogenic protein 2-inducible kinase (), Nipped-B-like protein (), A Kinase Anchoring Protein 8 (), Chromosome 11 Open Reading Frame 74 (), DEAD-Box Helicase 42 (), ATP Synthase F1 Subunit Gamma (), Euchromatic Histone Lysine Methyltransferase 1 (), Testic Expressed 41 (), etc. Patients diagnosed with ALL harboring ZNF384 rearrangements commonly had a good prognosis. The mechanisms, performance, and features of different ZNF384 rearrangements in acute lymphoblastic leukemia have been well evaluated. - Source: PubMed
Zhu LiwenBai WenkeCheng QianyiFang Jianpei - NWC is an uncharacterised protein containing three strongly conserved domains not found in any other known protein. Previously, we reported that the NWC protein is detected in cells in the germinal layer in murine testes (strain: C57BL/6), and its knockout results in no obvious phenotype. We determined the NWC expression pattern during spermatogenesis, and found this protein in spermatocytes and round spermatids, but not in epididymal sperm. Although NWC knockout males are fertile, we further characterised their reproductive potential employing non-standard mating that better simulates the natural conditions by including sperm competition. Such an approach revealed that the sperm of knockout males fail to successfully compete with control sperm. After analysing selected characteristics of the male reproductive system, we found that NWC knockout sperm had a reduced ability to fertilize cumulus-intact eggs during IVF. This is the first report describing a subtle phenotype of NWC knockout mice that could be detected under non-standard mating conditions. Our results indicate that NWC plays an important role in spermatogenesis and its deficiency results in the production of functionally impaired sperm. - Source: PubMed
Publication date: 2018/12/06
Majkowski MichalLaszkiewicz AgnieszkaSniezewski LukaszGrzmil PawelPawlicka BernadettaTomczyk IgorMichniewicz MartynaKapusniak ViolettaJanik SylwiaChodaczek GrzegorzCebrat Malgorzata - Cilia are organelles that serve as cellular antennae. Intraflagellar transport particles containing the IFT-A and IFT-B complexes mediate bidirectional trafficking of ciliary proteins. Particularly, in concert with the BBSome complex, IFT particles play an essential role in trafficking of ciliary G-protein-coupled receptors (GPCRs). Therefore, proteins interacting with the IFT components are potential regulators of ciliary protein trafficking. We here revealed that an uncharacterized protein, C11ORF74, interacts with the IFT-A complex via the IFT122 subunit and is accumulated at the distal tip in the absence of an IFT-A subunit IFT139, suggesting that at least a fraction of C11ORF74 molecules can be transported towards the ciliary tip by associating with the IFT-A complex, although its majority might be out of cilia at steady state. In C11ORF74-knockout (KO) cells, the BBSome components cannot enter cilia. However, trafficking of Smoothened or GPR161, both of which are ciliary GPCRs involved in Hedgehog signalling and undergo BBSome-dependent trafficking, was not affected in the absence of C11ORF74. In addition, C11orf74/B230118H07Rik- KO mice demonstrated no obvious anatomical abnormalities associated with ciliary dysfunctions. Given that C11ORF74 is conserved across vertebrates, but not found in other ciliated organisms, such as nematodes and Chlamydomonas, it might play limited roles involving cilia. - Source: PubMed
Takahara MarikoKunii MasatakaNakamura KentaroHarada AkihiroHirano TomoakiKatoh YoheiNakayama Kazuhisa