Ask about this productRelated genes to: C8ORF34 antibody
- Gene:
- C8orf34 NIH gene
- Name:
- chromosome 8 open reading frame 34
- Previous symbol:
- -
- Synonyms:
- vest-1, VEST1
- Chromosome:
- 8q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-20
- Date modifiied:
- 2017-10-25
Related products to: C8ORF34 antibody
Related articles to: C8ORF34 antibody
- Tobacco smoking drives complex genetic and epigenetic changes in non-small cell lung cancer (NSCLC), but the interplay between these alterations remains incompletely understood. This study investigates methylation-driven gene expression changes associated with smoking in lung adenocarcinoma and lung squamous cell carcinoma, with a focus on identifying prognostic biomarkers and gaining etiologic insights using a tracts of homozygosity (TOH)-based framework. - Source: PubMed
Jin JingRahmatallah YasirGomez-Acevedo HoracioPark Yong-Moon MarkUssery David WJakoet EbrahimOrloff Mohammed S - Neurons in the dorsal root ganglion (DRG) receive and transmit sensory information from the tissues they innervate and from the external environment. Upper cervical (C1-C2) DRGs are functionally unique as they receive input from the neck, head and occipital cranial dura, the latter two of which are also innervated by the trigeminal ganglion (TG). The C2 DRG also plays an important role in neck pain, a common and disabling disorder that is poorly understood. Advanced transcriptomic approaches have significantly improved our ability to characterize RNA expression patterns at single-cell resolution in the DRG and TG, but no previous studies have characterized the C2 DRG. Our aim was to use single-nucleus and spatial transcriptomic approaches to create a molecular map of C2 DRGs from patients undergoing arthrodesis surgery with ganglionectomy. Patients with acute (<3 months) or chronic (≥3 months) neck pain were enrolled and completed patient-reported outcome and somatosensory measures prior to surgery. C2 DRGs were characterized with bulk, single-nucleus and spatial RNA sequencing technologies from 22 patients. Through a comparative analysis to published datasets of the lumbar DRG and TG, neuronal clusters identified in both TG and DRG were identified in the C2 DRG. Therefore, our study characterizes the molecular composition of human C2 neurons and establishes their similarity with unique characteristics of subsets of TG neurons. We identified differentially expressed genes in endothelial, fibroblast and myelinating Schwann cells associated with chronic pain, including FGFBP2, C8orf34 and EFNA1, which have been identified in previous genome- and transcriptome-wide association studies. Our work provides the first characterization of the human C2 DRG and identifies altered gene expression patterns associated with chronic neck pain. This work establishes a foundation for the exploration of painful disorders in humans affecting the cervical spine. - Source: PubMed
Arendt-Tranholm AstaSankaranarayanan IshwaryaPayne CathrynMancilla Moreno MarisolMazhar KhadijahYap NatalieChiu Abby PBarry AllisonPatel Pooja JInturi Nikhil NTavares-Ferreira DianaAmin AnubhavKarandikar MaheshJarvik Jeffrey GTurner Judith AHofstetter Christoph PCuratolo MichelePrice Theodore J - Neurons in the dorsal root ganglion (DRG) receive and transmit sensory information from the tissues they innervate and from the external environment. Upper cervical (C1-C2) DRGs are functionally unique as they receive input from the neck, head, and occipital cranial dura, the latter two of which are also innervated by the trigeminal ganglion (TG). The C2 DRG also plays an important role in neck pain, a common and disabling disorder that is poorly understood. Advanced transcriptomic approaches have significantly improved our ability to characterize RNA expression patterns at single-cell resolution in the DRG and TG, but no previous studies have characterized the C2 DRG. Our aim was to use single-nucleus and spatial transcriptomic approaches to create a molecular map of C2 DRGs from patients undergoing arthrodesis surgery with ganglionectomy. Patients with acute (<3 months) or chronic (≥3 months) neck pain were enrolled and completed patient-reported outcomes and quantitative sensory testing prior to surgery. C2 DRGs were characterized with bulk, single nucleus, and spatial RNA sequencing technologies from 22 patients. Through a comparative analysis to published datasets of the lumbar DRG and TG, neuronal clusters identified in both TG and DRG were identified in the C2 DRG. Therefore, our study definitively characterizes the molecular composition of human C2 neurons and establishes their similarity with unique characteristics of subsets of TG neurons. We identified differentially expressed genes in endothelial, fibroblast and myelinating Schwann cells associated with chronic pain, including and which have been identified in previous genome and transcriptome wide association studies (GWAS/TWAS). Our work establishes an atlas of the human C2 DRG and identifies altered gene expression patterns associated with chronic neck pain. This work establishes a foundation for the exploration of painful disorders in humans affecting the cervical spine. - Source: PubMed
Publication date: 2025/03/30
Arendt-Tranholm AstaSankaranarayanan IshwaryaPayne CathrynMoreno Marisol MancillaMazhar KhadijahYap NatalieChiu Abby PBarry AllisonPatel Pooja PInturi Nikhil NFerreira Diana TavaresAmin AnubhavKarandikar MaheshJarvik Jeffrey GTurner Judith AHofstetter Christoph PCuratolo MichelePrice Theodore J - Ferroptosis is an iron-dependent type of regulated cell death, and has been implicated in lung adenocarcinoma (LUAD). Evidence has proved the key role of glutamate-cysteine ligase catalytic subunit (GCLC) in ferroptosis, but its role in LUAD remains unclear. Herein, we explored the implications of GCLC and relevant genes in LUAD prognosis and immunity as well as underlying molecular mechanisms. - Source: PubMed
Publication date: 2024/05/15
Huang ZhongLiang FeifeiWu JiangtaoHuang ZichongLi YinglianHuang XiaoyuanLiu Zhenyu - Adenoid cystic carcinoma (AdCC) is a rare, indolent salivary gland tumor that is reported to be driven by fusion genes. However, MYB/MYBL1-NFIB fusions have been detected in <60% of all AdCC cases and the oncogenic driver mutations in approximately 40% of AdCC remain unknown. Our aim was to identify novel gene fusions in AdCC. - Source: PubMed
Publication date: 2021/03/31
Shibata EriMorita Kei-IchiKayamori KouTange ShoichiroShibata HirokiHarazono YosukeMichi YasuyukiIkeda TohruHarada HiroyukiImoto IsseiYoda Tetsuya