Ask about this productRelated genes to: CENTB5 antibody
- Gene:
- ACAP3 NIH gene
- Name:
- ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
- Previous symbol:
- CENTB5
- Synonyms:
- KIAA1716
- Chromosome:
- 1p36.33
- Locus Type:
- gene with protein product
- Date approved:
- 2001-10-29
- Date modifiied:
- 2019-03-21
Related products to: CENTB5 antibody
Related articles to: CENTB5 antibody
- Intra-articular drug delivery systems (DDS) are emerging as promising therapies for osteoarthritis (OA), yet their efficacy in spontaneous clinical cases remains largely untested. This uncontrolled, descriptive pilot study was designed to provide a proof of concept for the feasibility, safety, and preliminary clinical effects of intra-articular administration in sport horses with naturally occurring OA. The study involved a peptide-functionalized nanogel composed of chitosan and hyaluronic acid, delivering endothelin type A (BQ-123) and bradykinin B1 (R-954) receptor antagonists, which have previously demonstrated anti-inflammatory and chondroprotective properties in preclinical models. - Source: PubMed
Publication date: 2026/03/03
Terlinden AntoinetteJacquet SandrineManivong SengCoudry VirginieTallaj AmelieCullier AurélieLegendre FlorenceGarcia Araceli AcMoldovan FlorinaSirois PierreBanquy XavierGaléra PhilippeAudigié FabriceRoullin GaëlleDemoor MagaliBertoni Lélia - Despite significant advances in diagnosis and therapy, the prognosis of late-stage lung adenocarcinoma (LUAD) remains poor, underscoring the urgent need for effective biomarkers to enable early detection. Epigenetic alterations, particularly DNA methylation, is essential for controlling gene expression, and its abnormality plays critical roles in promoting carcinogenesis. - Source: PubMed
Publication date: 2026/01/10
Dong ZhixiongXie WenranZhang NingxinGuo YingZhang YuruiLiu YangyangLin ChengbinShao Fanggui - Locomotor disorders involving the spine are a major cause of impaired performance and early retirement in sport horses. Swimming is increasingly incorporated into rehabilitation protocols, but its effects on spinal biomechanics remain poorly understood. This prospective study evaluated changes in thoracolumbar mobility in sixteen sport horses diagnosed with cervical or thoracolumbar axial musculoskeletal lesions over a 12-week rehabilitation program comprising 4 weeks of land-based training followed by 8 weeks during which swimming sessions were incorporated three times per week. Weekly measurements of thoracolumbar flexion-extension range of motion (ROM) were performed during straight-line trot on a hard surface using inertial measurement units attached to the withers, T18, and tubera sacrale. Group-level analyses revealed minimal changes across training phases: in horses with thoracolumbar lesions, mean ROM decreased slightly during the second month of aquatic training (-0.1° [95% CI -0.1; 0], Cohen's d = 0.2), whereas no significant variation was detected in horses with cervical lesions. As the study did not include a control group, these temporal changes cannot be specifically attributed to swimming and should be interpreted as descriptive rather than causal. Individual trajectories showed heterogeneous patterns, but these were not consistent enough to alter the group-level interpretation. Overall, the findings suggest that thoracolumbar mobility remains relatively stable throughout this type of rehabilitation program, highlighting the importance of individualized monitoring rather than the expectation of a uniform biomechanical response. - Source: PubMed
Publication date: 2025/12/30
Pécresse BaptisteMoiroud ClaireHanne-Poujade SandrineHatrisse ChloéDe Azevedo EmelineCoudry VirginieJacquet SandrineAudigié FabriceChateau Henry - Disuse-induced bone loss during stall confinement and immobilization is a major concern in horses because it impairs recovery and increases susceptibility to further injury. Experimental models are needed to evaluate therapeutic options, but most available equine models rely on cast immobilization, which is technically demanding and may be associated with complications. This study aimed to assess a simpler and less restrictive model to induce a quantifiable decrease in bone density in horses. Six French Standardbred horses underwent eight weeks of stall confinement, with a wooden wedge fitted to one front foot to elevate the heels during the last four weeks. Bone density was assessed using computed tomography (CT) examinations of both forelimbs performed at the beginning (M0) and after the confinement period (M2). Serum markers of bone metabolism (CTX-I, osteocalcin, bone-specific alkaline phosphatase, and hydroxyproline) were analyzed monthly from baseline to 2 months post confinement. Statistical analysis used Wilcoxon signed-rank tests and mixed models as appropriate. Computed tomography revealed a significant decrease in bone density after confinement ( < 0.05), more pronounced distally in the wedge limb. CTX-I levels varied with physical activity. This model provides a practical and reproducible alternative to cast immobilization for inducing equine bone demineralization. - Source: PubMed
Publication date: 2025/10/29
Micheau LisaAudigié FabriceMoiroud ClaireJacquet Sandrine - Intravenous regional limb perfusion (IVRLP) of antibiotics is a therapeutic method used to treat distal limb infections in horses. The objectives of this study were to determine the pharmacokinetic parameters and tolerance of sodium benzylpenicillin (NaBP) administered via IVRLP; to compare the feasibility, tolerance, and efficacy of performing IVRLP on a flexed limb versus a weightbearing limb; and to predict the efficacy of IVRLP using gentamicin or NaBP. A prospective crossover study was conducted with six horses, each undergoing four phases of antibiotic infusion (gentamicin at 2.2 mg/kg vs. NaBP at 7,333 IU/kg of BP) and limb positioning (weightbearing vs. flexed). Each antibiotic administration was followed by serial synovial and blood sampling to assess antibiotic concentrations. Inflammation and sensitivity to palpation were evaluated at both the injection site and the sampled joint. A pharmacokinetic/pharmacodynamic analysis was carried out to predict the efficacy of IVRLP by estimating area under the concentration-time curve to minimum inhibitory concentration (AUC/MIC) index values for various minimum inhibitory concentrations (MICs). - Source: PubMed
Publication date: 2025/11/07
Guillot MargueriteMespoulhes-Rivière CélineBousquet-Mélou AlainLacroix Marlène ZRoques Béatrice BLallemand Elodie A