Ask about this productRelated genes to: CENTB5 antibody
- Gene:
- ACAP3 NIH gene
- Name:
- ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
- Previous symbol:
- CENTB5
- Synonyms:
- KIAA1716
- Chromosome:
- 1p36.33
- Locus Type:
- gene with protein product
- Date approved:
- 2001-10-29
- Date modifiied:
- 2019-03-21
Related products to: CENTB5 antibody
Related articles to: CENTB5 antibody
- Equine swimming is increasingly used for injury prevention and rehabilitation, but objective analysis of movement during swimming remains limited compared to land-based locomotion. Spatiotemporal parameters are essential for evaluating therapeutic outcomes, yet capturing these parameters is technically challenging due to difficulties in observing limb motion in water. Inertial sensors, already widely applied in equine science, offer a promising solution for measuring swimming kinematics objectively. The objective of this study was to evaluate the reliability of inertial sensors placed on equine distal limbs in detecting key spatiotemporal events during swimming by comparing it with video-based detection made by veterinarians. For the duration of the hindlimb swimming cycle, 24 data values were analysed and showed an "excellent" agreement, with an intraclass correlation coefficient = 0.96, 95% CI: 0.904-0.983, and Bland-Altmann analysis showed an upper limit of agreement of 50 ms (95% CI: 70 ms, 30 ms) and lower one of -60 ms (95% CI: -40 ms, -80 ms). The estimates of the "swimming" duty factor of the hindlimb (n = 24) demonstrated "moderate" to "excellent" with intraclass correlation of 0.82 (95% CI: 0.625-0.920) and limits of agreement of 4.39% (95% CI: 6.21%, 2.53%) and -5.28% (95% CI: -3.42%, -7.14%). The results of the forelimb were mixed, suggesting that the cycle duration and "swimming" duty factor parameters determined for this limb should be used with caution. Overall, the findings confirm that inertial sensors, particularly on the hindlimbs, provide reliable spatiotemporal measurements and are well suited for studying equine swimming. - Source: PubMed
Publication date: 2026/04/28
Marin FredericGiraudet ChloéGaulmin PaulineMoiroud ClaireDe Azevedo EmelineHatrisse ChloéBen Mansour KhalilMartin PaulineAudigie FabriceChateau Henry - Intra-articular drug delivery systems (DDS) are emerging as promising therapies for osteoarthritis (OA), yet their efficacy in spontaneous clinical cases remains largely untested. This uncontrolled, descriptive pilot study was designed to provide a proof of concept for the feasibility, safety, and preliminary clinical effects of intra-articular administration in sport horses with naturally occurring OA. The study involved a peptide-functionalized nanogel composed of chitosan and hyaluronic acid, delivering endothelin type A (BQ-123) and bradykinin B1 (R-954) receptor antagonists, which have previously demonstrated anti-inflammatory and chondroprotective properties in preclinical models. - Source: PubMed
Publication date: 2026/03/03
Terlinden AntoinetteJacquet SandrineManivong SengCoudry VirginieTallaj AmelieCullier AurélieLegendre FlorenceGarcia Araceli AcMoldovan FlorinaSirois PierreBanquy XavierGaléra PhilippeAudigié FabriceRoullin GaëlleDemoor MagaliBertoni Lélia - Despite significant advances in diagnosis and therapy, the prognosis of late-stage lung adenocarcinoma (LUAD) remains poor, underscoring the urgent need for effective biomarkers to enable early detection. Epigenetic alterations, particularly DNA methylation, is essential for controlling gene expression, and its abnormality plays critical roles in promoting carcinogenesis. - Source: PubMed
Publication date: 2026/01/10
Dong ZhixiongXie WenranZhang NingxinGuo YingZhang YuruiLiu YangyangLin ChengbinShao Fanggui - Locomotor disorders involving the spine are a major cause of impaired performance and early retirement in sport horses. Swimming is increasingly incorporated into rehabilitation protocols, but its effects on spinal biomechanics remain poorly understood. This prospective study evaluated changes in thoracolumbar mobility in sixteen sport horses diagnosed with cervical or thoracolumbar axial musculoskeletal lesions over a 12-week rehabilitation program comprising 4 weeks of land-based training followed by 8 weeks during which swimming sessions were incorporated three times per week. Weekly measurements of thoracolumbar flexion-extension range of motion (ROM) were performed during straight-line trot on a hard surface using inertial measurement units attached to the withers, T18, and tubera sacrale. Group-level analyses revealed minimal changes across training phases: in horses with thoracolumbar lesions, mean ROM decreased slightly during the second month of aquatic training (-0.1° [95% CI -0.1; 0], Cohen's d = 0.2), whereas no significant variation was detected in horses with cervical lesions. As the study did not include a control group, these temporal changes cannot be specifically attributed to swimming and should be interpreted as descriptive rather than causal. Individual trajectories showed heterogeneous patterns, but these were not consistent enough to alter the group-level interpretation. Overall, the findings suggest that thoracolumbar mobility remains relatively stable throughout this type of rehabilitation program, highlighting the importance of individualized monitoring rather than the expectation of a uniform biomechanical response. - Source: PubMed
Publication date: 2025/12/30
Pécresse BaptisteMoiroud ClaireHanne-Poujade SandrineHatrisse ChloéDe Azevedo EmelineCoudry VirginieJacquet SandrineAudigié FabriceChateau Henry - Disuse-induced bone loss during stall confinement and immobilization is a major concern in horses because it impairs recovery and increases susceptibility to further injury. Experimental models are needed to evaluate therapeutic options, but most available equine models rely on cast immobilization, which is technically demanding and may be associated with complications. This study aimed to assess a simpler and less restrictive model to induce a quantifiable decrease in bone density in horses. Six French Standardbred horses underwent eight weeks of stall confinement, with a wooden wedge fitted to one front foot to elevate the heels during the last four weeks. Bone density was assessed using computed tomography (CT) examinations of both forelimbs performed at the beginning (M0) and after the confinement period (M2). Serum markers of bone metabolism (CTX-I, osteocalcin, bone-specific alkaline phosphatase, and hydroxyproline) were analyzed monthly from baseline to 2 months post confinement. Statistical analysis used Wilcoxon signed-rank tests and mixed models as appropriate. Computed tomography revealed a significant decrease in bone density after confinement ( < 0.05), more pronounced distally in the wedge limb. CTX-I levels varied with physical activity. This model provides a practical and reproducible alternative to cast immobilization for inducing equine bone demineralization. - Source: PubMed
Publication date: 2025/10/29
Micheau LisaAudigié FabriceMoiroud ClaireJacquet Sandrine