Ask about this productRelated genes to: CENTB5 antibody
- Gene:
- ACAP3 NIH gene
- Name:
- ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
- Previous symbol:
- CENTB5
- Synonyms:
- KIAA1716
- Chromosome:
- 1p36.33
- Locus Type:
- gene with protein product
- Date approved:
- 2001-10-29
- Date modifiied:
- 2019-03-21
Related products to: CENTB5 antibody
Related articles to: CENTB5 antibody
- In clinical practice, lameness evaluation often relies on visual assessment under different examination conditions, including ground and figures, and remains subjective. Although objective symmetry indices provide quantitative measures of gait asymmetry, their interpretation across multiple conditions remains challenging because several complementary indices are required and their thresholds vary with context. - Source: PubMed
Publication date: 2026/09/13
Gérard MahautHanne-Poujade SandrineDubois GuillaumeHébert CamilleCoudry VirginieJacquet SandrineBertoni LéliaTallaj AmélieMezghani NeilaChateau Henry - To quantitatively describe changes in skeletal radiopharmaceutical uptake during a training program including swimming in horses with neck and back pain, eighteen showjumping horses with documented vertebral lesions were prospectively included in a training program composed of 4 weeks of ridden work and then 8 weeks combining swimming and ridden exercise. Previously published data on this cohort did not demonstrate any clear change in thoracolumbar mobility. Bone scintigraphy was performed at the 4th and 12th weeks. Radiopharmaceutical uptake was quantified in 205 regions of interest (ROIs) and normalized using a Z-score approach. For each ROI, a linear mixed-effects model was fitted to evaluate the effect of the time point (W4, W12) on the normalized radiopharmaceutical uptake with the horse as a random effect. Overall variation in normalized signal intensity (Z-score difference W12-W04) was small (mean < 0.001; range -0.28 to 0.24). Significant changes between time points were identified in 21 ROIs. Thirteen ROIs located in the axial skeleton showed a decreased radiopharmaceutical uptake, whereas eight ROIs located in the limbs, including the humeral tubercles on both lateral views, showed an increased uptake. During a 2-month training program including swimming, axial skeletal radiopharmaceutical uptake did not increase in this cohort of horses with neck and back pain. However, substantial interindividual variability in scintigraphic changes was observed. Further controlled studies are needed to confirm these preliminary results and to better explore the effects of swimming on horses with axial musculoskeletal disorders. - Source: PubMed
Publication date: 2026/08/13
Prémont AntoineMoiroud ClaireJacquet SandrineBeaumont AudreyBertoni LéliaChateau HenryAudigié Fabrice - Equine swimming is increasingly used for injury prevention and rehabilitation, but objective analysis of movement during swimming remains limited compared to land-based locomotion. Spatiotemporal parameters are essential for evaluating therapeutic outcomes, yet capturing these parameters is technically challenging due to difficulties in observing limb motion in water. Inertial sensors, already widely applied in equine science, offer a promising solution for measuring swimming kinematics objectively. The objective of this study was to evaluate the reliability of inertial sensors placed on equine distal limbs in detecting key spatiotemporal events during swimming by comparing it with video-based detection made by veterinarians. For the duration of the hindlimb swimming cycle, 24 data values were analysed and showed an "excellent" agreement, with an intraclass correlation coefficient = 0.96, 95% CI: 0.904-0.983, and Bland-Altmann analysis showed an upper limit of agreement of 50 ms (95% CI: 70 ms, 30 ms) and lower one of -60 ms (95% CI: -40 ms, -80 ms). The estimates of the "swimming" duty factor of the hindlimb (n = 24) demonstrated "moderate" to "excellent" with intraclass correlation of 0.82 (95% CI: 0.625-0.920) and limits of agreement of 4.39% (95% CI: 6.21%, 2.53%) and -5.28% (95% CI: -3.42%, -7.14%). The results of the forelimb were mixed, suggesting that the cycle duration and "swimming" duty factor parameters determined for this limb should be used with caution. Overall, the findings confirm that inertial sensors, particularly on the hindlimbs, provide reliable spatiotemporal measurements and are well suited for studying equine swimming. - Source: PubMed
Publication date: 2026/04/28
Marin FredericGiraudet ChloéGaulmin PaulineMoiroud ClaireDe Azevedo EmelineHatrisse ChloéBen Mansour KhalilMartin PaulineAudigie FabriceChateau Henry - Intra-articular drug delivery systems (DDS) are emerging as promising therapies for osteoarthritis (OA), yet their efficacy in spontaneous clinical cases remains largely untested. This uncontrolled, descriptive pilot study was designed to provide a proof of concept for the feasibility, safety, and preliminary clinical effects of intra-articular administration in sport horses with naturally occurring OA. The study involved a peptide-functionalized nanogel composed of chitosan and hyaluronic acid, delivering endothelin type A (BQ-123) and bradykinin B1 (R-954) receptor antagonists, which have previously demonstrated anti-inflammatory and chondroprotective properties in preclinical models. - Source: PubMed
Publication date: 2026/03/03
Terlinden AntoinetteJacquet SandrineManivong SengCoudry VirginieTallaj AmelieCullier AurélieLegendre FlorenceGarcia Araceli AcMoldovan FlorinaSirois PierreBanquy XavierGaléra PhilippeAudigié FabriceRoullin GaëlleDemoor MagaliBertoni Lélia - Despite significant advances in diagnosis and therapy, the prognosis of late-stage lung adenocarcinoma (LUAD) remains poor, underscoring the urgent need for effective biomarkers to enable early detection. Epigenetic alterations, particularly DNA methylation, is essential for controlling gene expression, and its abnormality plays critical roles in promoting carcinogenesis. - Source: PubMed
Publication date: 2026/01/10
Dong ZhixiongXie WenranZhang NingxinGuo YingZhang YuruiLiu YangyangLin ChengbinShao Fanggui