Ask about this productRelated genes to: MTHFS antibody
- Gene:
- MTHFS NIH gene
- Name:
- methenyltetrahydrofolate synthetase
- Previous symbol:
- -
- Synonyms:
- HsT19268
- Chromosome:
- 15q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-09
- Date modifiied:
- 2017-01-03
Related products to: MTHFS antibody
Related articles to: MTHFS antibody
- The silk gland is a specialized organ for silk protein synthesis in Bombyx mori. BmFoxA is considered an important transcription factor regulating silk protein gene expression. However, as a multifunctional transcription factor highly homologous to the mammalian pioneer factor FoxA1 and the Drosophila Fkh, large-scale identification of BmFoxA downstream genes and studies on its functional diversity in silkworms remain limited. In this study, we performed integrated multi-omics analyses, including RNA-seq, ChIP-seq (BmFoxA, H3K4me3, H3K27ac), and ATAC-seq, on silk gland tissues from three developmental stages: the fourth instar molting stage (4m), the fifth instar three days (5d3), and the prepupal stage (pp). Firstly, we mapped the temporal expression profile and genome-wide binding landscape of BmFoxA. Next, we annotated the promoter regions of 9473 silkworm genes using H3K4me3 and H3K27ac ChIP-seq data as promoter-associated markers, thereby constructing a more accurate promoter level stage-specific regulatory network for BmFoxA. Gene enrichment analysis showed that BmFoxA primarily regulates genes related to DNA binding, cell cycle, metabolism, and developmental processes across the three developmental stages. Using our refined regulatory network of BmFoxA, we identified and verified three stage-specific target genes MTHFD2L, MTHFS and Cdk20, which were involved in one-carbon metabolism, cell cycle progression and are positively regulated by BmFoxA at 5d3, contributing to the maintenance of material and energy metabolism. This study systematically delineates the transcriptional regulatory landscape of BmFoxA in silkworm, expanding its functional scope beyond silk protein gene expression to include stage-dependent coordination of metabolic programs. By constructing a high-confidence, promoter-level BmFoxA regulatory network, we provide a valuable resource and paradigm for future investigations into silk gland gene regulation, protein biosynthesis, and the broader functional potential of BmFoxA in specialized insect organs. - Source: PubMed
Publication date: 2026/03/25
Zhang QuanSun YuetingZhang RuoxuanTang PeikunXia Qingyou - China's Multi-tiered Health Financing System (MTHFS) integrates basic medical insurance, critical illness coverage, and the Medical Assistance System (MAS) to advance Universal Health Coverage (UHC). While the MAS targets low-income populations, the degree of financial protection and equity in healthcare access it affords remains incompletely understood. This cross-sectional study aims to describe patterns of healthcare utilization and analyze the incidence and determinants of catastrophic health expenditure (CHE) among low-income groups under the MTHFS. - Source: PubMed
Publication date: 2026/02/25
Zhang XiaojuanZhu KunCui YueyingFeng Ruihua - Dysregulated one-carbon metabolism occurs in metabolic dysfunction-associated steatotic liver disease (MASLD) and in models of liver fibrosis, but two fibrosis models display opposing methylation cycle profiles, which has been a point of confusion. Broader changes in one-carbon related metabolism and the consequent impact on transcriptional events have not been fully explored. - Source: PubMed
Publication date: 2026/01/08
da Silva Robin PEudy Brandon J - The occurrence of ischemic heart disease (IHD), atrial fibrillation, and flutter demonstrates certain associations with inflammatory bowel disease (IBD), warranting further exploration at the genetic architecture level. This study focused on genome-wide association study (GWAS) data of IHD, atrial fibrillation and flutter, and IBD, analyzing from two dimensions: genetic correlation and shared locus identification. Initially, linkage disequilibrium score regression and genetic covariance analyzer were utilized to assess the overall genetic correlations. Subsequently, the association patterns of local genomic regions were determined using Local Ancestry Variance Association (LAVA) analysis. Mendelian randomization (MR) was employed to assess causal effects. The genetic overlap among different traits was analyzed based on the statistical framework of conditional/conjunctional false discovery rate (cond/conjFDR). Finally, shared loci across these traits were identified by integrating conjFDR analysis with GWAS multi-trait analysis (MTAG). At the genomic level, significant overall correlations were observed among IHD, atrial fibrillation and flutter, and IBD and Crohn's disease (CD), while associations with ulcerative colitis appeared less pronounced. At the local level, IHD and IBD (including subtypes) showed significant associations in multiple regions. However, atrial fibrillation and flutter exhibited local associations only in the context of CD. Through conjFDR analysis, the genetic overlap across these diseases was validated. Additionally, several shared genetic loci were identified by integrating conjFDR and MTAG analyses, with genes confirmed in both IHD and IBD (including subtypes), such as SMAD3, PLCG2, ZNF831, PTPN22, RP11-136O12.2, and RP11-449I17.5. Moreover, six common genes were identified in the analysis between atrial fibrillation and flutter and IBD (including subtypes), such as ZMIZ1, MTHFS, ERAP2, GNA12, and RP1-15D23.2. This study offers empirical evidence of the genetic association between IHD, atrial fibrillation and flutter, and IBD comorbidity, providing new insights for cases where IBD co-occurs with IHD or atrial fibrillation and flutter. - Source: PubMed
Publication date: 2025/05/08
Chen GuojianLuo QinghuaWu ChengchengXie Mingjun - Metabolic reprogramming is currently considered a hallmark of tumor and immune development. It is obviously of interest to identify metabolic enzymes that are associated with clinical prognosis in head and neck squamous cell carcinomas (HNSCC). - Source: PubMed
Publication date: 2024/04/16
Wang LuHe YeBai YijiangZhang ShuaiPang BoChen AnhaiWu Xuewen