Ask about this productRelated genes to: FAM113A antibody
- Gene:
- PCED1A NIH gene
- Name:
- PC-esterase domain containing 1A
- Previous symbol:
- C20orf81, FAM113A
- Synonyms:
- bA12M19.1, FLJ22376
- Chromosome:
- 20p13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-07-17
- Date modifiied:
- 2014-11-19
Related products to: FAM113A antibody
Related articles to: FAM113A antibody
- The heterogeneity of colorectal cancer (CRC) necessitates a comprehensive understanding of its pathogenesis and the identification of potential therapeutic targets. This research aims to report on PCED1A, a gene that has not been reported in any cancer, and to focus on investigating its role in CRC. - Source: PubMed
Publication date: 2025/08/07
Wang ChunZhang DahongHuang Yushen - Succinylation, a key post-translational modification, plays a crucial role in metabolic regulation and tumor progression. However, its influence on the tumor immune microenvironment and its prognostic implications remain unclear. A systematic pan-cancer analysis of succinylation-related molecular activities is needed. - Source: PubMed
Publication date: 2025/05/20
Jiang ZhihangLi XiaoqingHu LongJiang Zheng - - Source: PubMed
Publication date: 2025/04/09
Filho Valbert Oliveira CostaPassos Pedro Robson Costa - Ovarian cancer remains one of the most lethal gynecological malignancies owing to its high recurrence rate and chemotherapeutic resistance. MYC is a well-known proto-oncogene that is frequently amplified in ovarian cancer and has been implicated in drug resistance. Previously, we established a new promoter-reporter system combined with a CRISPR activation library to identify unknown MYC regulators, and M1AP was identified as a novel MYC regulator. However, considering the insufficient explanation for the absence of guide RNA (gRNA) of MYC, this present study explored methods to prevent the gRNA of MYC itself from binding. This study first modified the promoter-reporter vector to improve its quality, then conducted CRISPR screening and analyzed candidate genes as MYC promoter regulators using next-generation sequencing in OVSAHO ovarian cancer cells. Eighty-six genes had ≥ 1000 reads, and Pearson's correlation coefficient analysis was performed on the cBioPortal of the Cancer Genomics database. Fourteen genes were identified as candidate MYC regulators with positive and significant correlations with MYC. Seven genes, including CYP4v2, ASPH, ANP32D, PCED1A, ABI1, FUZ, and HOOK2, demonstrated significantly higher luciferase activity than the control genes. Four genes, including ABI1, PCED1A, HOOK2, and CYP4v2, activated the MYC promoter, which showed over twofold higher activity than the control when overexpressed using a vector. In conclusion, four genes that activate MYC promoters were identified in an ovarian cancer cell line using the CRISPR library system with a modified promoter-reporter tool. These results will prove helpful in the development of novel treatment strategies for ovarian cancer. - Source: PubMed
Publication date: 2025/04/02
Yamamoto AkikoTanaka YosukeIshibashi SachikoIkeda MasumiSugita KeisukeOno MasanoriNishi HirotakaKurata Morito - Hepatocellular carcinoma (HCC) and colorectal cancer (CRC) pose a significant threat to human health worldwide, characterized by intricate pathogenesis. A PC-esterase domain containing 1A (PCED1A) is a critical number of the GDSL/SGNH superfamily. - Source: PubMed
Publication date: 2025/01/26
Wang MeilingZhang QiqiWang Jing