Ask about this productRelated genes to: HOMER1 antibody
- Gene:
- HOMER1 NIH gene
- Name:
- homer scaffold protein 1
- Previous symbol:
- -
- Synonyms:
- Ves-1, SYN47, HOMER-1B
- Chromosome:
- 5q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-28
- Date modifiied:
- 2018-03-01
Related products to: HOMER1 antibody
Related articles to: HOMER1 antibody
- We previously reported that germline complement deletion protected cognition and hippocampal synapses in aged APP/PS1dE9 mice despite increased amyloid plaques. To assess whether global C3 lowering in adult amyloid mice might be neuroprotective, we crossed our C3 inducible conditional mice with knockin mice. - Source: PubMed
Publication date: 2025/12/20
Singh BrijendraBatista Andre FSpooner Emma TColletti Brianna RSaido Takaomi CCarroll Michael CLemere Cynthia A - Streptozotocin-induced diabetic rats (STZ rats), an established animal model of type 1 diabetes mellitus, develop cognitive decline, which has been linked to impairments in hippocampal synaptic plasticity. Long-term depression (LTD) in the hippocampus may be induced by the activation of different types of G protein-coupled receptors, particularly metabotropic glutamate receptors (mGluRs) and muscarinic acetylcholine receptors. We previously demonstrated that acetylcholine receptor activation-dependent LTD was impaired in STZ rats, and herein investigated group I mGluR (mGluR1/5)-dependent LTD in the Schaffer collateral-CA1 synapses of STZ rats. Extracellular field recordings revealed that the chemical activation of mGluR1/5 with (S)-3,5-dihydroxyphenylglycine (DHPG, 50 μM, 10 min) induced sustained LTD in both control and STZ rats; however, the magnitude of DHPG-LTD was significantly smaller in STZ rats. Moreover, the paired-pulse ratio between before and 80 min after the application of DHPG increased in both control and STZ rats, and DHPG-LTD was independent of NMDA receptor activation. A Western blot analysis showed that DHPG-induced extracellular signal-regulated kinase (ERK) phosphorylation was reduced in STZ rats, whereas DHPG-induced phosphoinositide-dependent kinase 1 phosphorylation and the expression level of the scaffold protein, Homer1, were unchanged. Collectively, these results suggest that impaired ERK/MAPK signaling affected hippocampal mGluR1/5-dependent LTD in STZ rats, and the dysregulation of ERK may contribute to diabetes-associated cognitive decline because of its crucial role in protein synthesis-dependent synaptic plasticity. - Source: PubMed
Publication date: 2026/04/01
Otsuka HayumaSasaki-Hamada SachieIshibashi HitoshiOka Jun-Ichiro - Traumatic brain injury (TBI) initiates complex neuroinflammatory cascades that significantly influence recovery outcomes. Although sex differences in neuroinflammation have been reported previously, findings remain inconclusive as the role of the female estrous cycle in post-injury responses is not well understood. In this study, we aimed to characterize sex-based differences in neuroinflammatory, vascular, and behavioral outcomes following TBI, with particular emphasis on the different phases of the estrous cycle in female mice. Male and female mice were subjected to controlled cortical impact (CCI) and subsequently assessed for behavioral deficits, cerebral blood flow (CBF), immune cell infiltration, and inflammatory genes expression. Although TBI induced robust neuroinflammation and reduction in CBF in both sexes, female mice showed significantly increased myeloid, microglial and T-cell presence, as well as elevated expression of key inflammatory transcripts (Btk, Inpp5d, and Tmem173), while downregulation in Grm2 expressions. Stratified cohort of female mice as per phases in estrous cycle (proestrus, estrus, metestrus, and diestrus) before injury showed alterations in Inpp5d, Csf3r, Csf1r, CD84, Tmem173, Homer1, Grm2 and Supt7l. Notably, female injured mice showed differential improvements in select parameters, although estrous cycle phase at the time of impact had limited but phase-dependent impact on CBF. Female mice did not show significant changes in the behavioral tests as compared to male or different estrous phenotypes. However, female mice showed higher frequency to visit center in an open arena. These findings highlight sex-specific neuroinflammatory and transcriptional responses to TBI, with moderate modulation by estrous cycle. Our study further suggests that one estrous phase could be more vulnerable to neuroinflammation or neurovascular injury than others on cellular and molecular level. However, this interphase difference might be masked in the studies including randomly cycled female population. Thus, our results underscore the importance of incorporating sex, estrous and hormonal status into sex-dependent studies on TBI and other brain diseases research to inform the development of targeted therapeutic strategies. - Source: PubMed
Publication date: 2026/03/04
Royal TabithaAhluwalia PankajGulhane MayuriSalles Evila LopesGaur PankajAhluwalia MeenakshiRandhawa TajmanSunil ShreyaBudim SriramAkter KhadijaKhan Mohammad BadruzzamanGhosh SantuBaban BabakHess David CVale Fernando LDhandapani Krishnan MKolhe RavindraVaibhav Kumar - Different morphological and pathological features of abnormal α-synuclein in synucleinopathies-multiple system atrophy (MSA) and Lewy body diseases, including Parkinson's disease (PD) and dementia with Lewy bodies (DLB)-may underlie disease-specific synaptic dysfunction. To compare synaptic profiles associated with abnormal α-synuclein, we examined temporal lobe tissues from patients with MSA (N = 4), DLB (N = 5), and controls (N = 9). We further analysed cerebrospinal fluid (CSF) samples from patients with early-stage MSA-parkinsonism (MSA-P: N = 8) and PD (N = 8) to determine whether synaptic alterations observed in brain tissue are reflected in CSF. Immunoblotting revealed significantly reduced levels of homer protein homolog 1 (HOMER1) and neuronal pentraxin-2 (NPTX2) in DLB brains than in controls, whereas levels of protein phosphatase 3 catalytic subunit α and calcineurin subunit B type 1 were significantly increased. In contrast, brains from patients with MSA-P exhibited significant elevations in disks large homolog 2 and HOMER1 relative to those in controls. Consistent with these findings, CSF levels of HOMER1 and NPTX2 were significantly lower in PD than in MSA-P. Notably, CSF HOMER1 levels showed a significant positive correlation with neurofilament light chain, a marker of neurodegeneration. Exploratory receiver operating characteristic analyses may help distinguish early-stage MSA-P from PD. These findings indicate that disease-specific synaptic alterations associated with abnormal α-synuclein are reflected in CSF, heightening the potential utility of synaptic proteins as candidate CSF signatures in early-stage MSA-P. - Source: PubMed
Publication date: 2026/02/26
Hatakeyama SakiMiki YasuoTanaka Makoto TimonShibuya EriUeno TatsuyaShimoyama ShujiNishijima HaruoArai AkiraSuzuki ChiekoTomiyama MasahikoKakita AkiyoshiWakabayashi Koichi - Understanding the functional mechanisms of genes influencing economically important traits in the domestic pig is essential for optimizing marker-assisted selection (MAS). This study aimed to characterize the biological functions, molecular mechanisms, and metabolic pathways of genes associated with morphological, productive, reproductive, and carcass quality traits through a functional bioinformatics approach. Genes were compiled from 116 peer-reviewed studies published between 2000 and 2024, and subsequently grouped according to trait. A de novo functional bioinformatics analysis was performed on this dataset. Functional enrichment analysis was conducted using DAVID and the clusterProfiler package in R, applying FDR correction (≤0.05). Protein-protein interaction (PPI) networks were explored using STRING. No individual gene was consistently reported with high frequency. Among the most frequently reported genes were (17 studies) for teat number, (3 studies) for leg strength, and (3 studies) for litter size. Enriched GO terms included processes such as positive regulation of transcription (GO:0045944), chondrocyte differentiation (GO:0032331), and SMAD signaling (GO:0060391; an FDR = 7.34 × 10). The PPI networks revealed key genes involved in signaling and immune regulation. In conclusion, this bioinformatics analysis provides an integrated functional overview of the genes underlying key economic traits in pigs, identifying pleiotropic pathways such as SMAD/TGF-β signaling, which supports the development of more effective MAS strategies in pig breeding programs. - Source: PubMed
Publication date: 2026/01/30
Hernández-Montiel WilberMeza-Villalvazo Víctor MDzib-Cauich Dany AZaldívar-Cruz Juan MAbad-Zavaleta JoséCob-Calan Nubia NoemiValenzuela-Jiménez NicolásZamora-Bustillos RobertoOsorio-Terán Amada I